Glycogen-rich adenocarcinoma in the lower lip: report of a case with particular emphasis on differential diagnosis

Kazumasa Mori, Jun Shimada, Nozomi Tamura, Nobuaki Tamura

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DOI: 10.4236/ojst.2011.13017                

Abstract

We herein report a glycogen-rich adenocarcinoma occurring in the lower lip of a 44-year-old female. The lesion appeared as painless slowly growing mass in the right side of the lower lip. Histologically, infil-trative tumor nests with duct-like or pseudocyst structure into the mucosa and/or dermis were ob-served. The basaloid neoplastic cells had granular but occasionally vacuolated cytoplasm with salient reaction of diastase-digestible periodic acid-Schiff, thus indicating that they were glycogen-rich in nature. The tumor cells were positive for CEA, cytokeratin, and S-100 protein, and negative for SMA, alpha-1 antitrypsin, and amylase by immunohistochemistry. The origin of the tumor with infiltrative nests was indistinguishable from salivary gland and skin ap-pendage malignancy. A differential diagnosis of this peculiar neoplasm was discussed.

Keywords

Adenocarcinoma; Glycogen; Differntial Diagnosis; Lower Lip

Conflicts of Interest

The authors declare no conflicts of interest.

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