Two Flavones from Acanthospermum hispidum DC and Their Antibacterial Activity

Theresa I. Edewor, Abass A. Olajire

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DOI: 10.4236/ijoc.2011.13020                

Abstract

Two new flavones, namely 5,7,2’,5’-tetrahydroxy-3,4’-dimethoxyflavone and 5’-acetoxy-5,7,2’-trihydroxy-3, 4’-dimethoxyflavone were successfuly isolated from the leaves of Acanthospermum hispidum DC and identified by UV-Vis, IR, ¹H-NMR and EI-MS techniques. Both compounds exhibited antibacterial activity against Salmonella typii, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Bacillus subtilis, Pseudomonas aeruginosa and Shigella dysenteriae with minimum inhibition concentration (MIC) ranging from 0.001 - 0.20 but was inactive against Escherichia coli, Corybacterium pyogenes and Proteus vulgaris.

Keywords

Acanthospermum hispidum DC, Flavonoids, Antibacterial, Spectroscopy

Conflicts of Interest

The authors declare no conflicts of interest.

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