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Healing Effect of the Extract of Kombucha in Male Wistar Rats

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DOI: 10.4236/ojvm.2015.54011    2,697 Downloads   3,105 Views  

ABSTRACT

In order to assess the impact of the early and late tissue repair of Kombucha extract on incised wounds in animal models, 24 Wistar male rats were used and divided into three groups: one of the groups received a topical cure on the wound with Brosin, and the other received the Kombucha extract. The third group did not receive any treatment, working as a control group. The objective was to evaluate and compare the Kombucha extract with a commercial healing product. Each one of the animals took a 1 cm wound in depth and length at a femur level on a side of the left thigh. The healing process was evaluated on an early and late phase by performing a morphometric and morphological analysis under the assumption of a faster recovery with the use of Kombucha. The results showed that there was a poor recovery in the control group. On the other hand, the other two groups, Brosin and Kombucha, were similar, with little inflammation and a high cell proliferation and migration along with basal array pulls of elastin and collagen which served for angiogenesis, repair and renovation of the new tissue.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Rosales-Cortés, M. , Albarrán-Rodríguez, E. , Nolasco-Rodríguez, G. , Avíla-Figueroa, D. , Cervantes-Mireles, R. , Rosales-Ramírez, R. and García-Carrasco, D. (2015) Healing Effect of the Extract of Kombucha in Male Wistar Rats. Open Journal of Veterinary Medicine, 5, 80-88. doi: 10.4236/ojvm.2015.54011.

References

[1] Eming, S.A., Krieg, T. and Davidson, J.M. (2007) Inflammation in Wound Repair: Molecular and Celular Mechanisms. Journal of Investigative Dermatology, 127, 514-521.
http://dx.doi.org/10.1038/sj.jid.5700701
[2] Furie, B. and Furie, C. (200) Mechanisms of Thrombus Formation. New England Journal of Medicine, 359, 938-949.
http://dx.doi.org/10.1056/NEJMra0801082
[3] Werner, S. and Grose, R. (2003) Regulation of Wound Healing by Growth Factors and Cytokines. Physiological Reviews, 83, 835-870.
[4] Rozman, P. and Bolta, Z. (2007) Use of Platelet Growth Factors in Treating Wounds and Soft-Tissue Injuries. Acta Dermatovenerologica Alpina, Pannonica et Adriatica, 16, 156-165.
[5] Kanurica, K.G., Hrnjeza, D.V., Ranogajeca, M.I., Milanovica, S.D., Ilicica, M.D., Vukica, V.R. and Milanovic. M. (2011) The Effect of Fermentation Temperature on the Functional Dairy Product Quality. Acta Periodicatechnologica, 42, 63-70.
http://dx.doi.org/10.2298/APT1142063K
[6] Cvetkovic, D. and Markov, S. (2002) Cultivation of Tea Fungus on Malt Extract Medium. Acta Periodica Technologica, 33, 117.
http://dx.doi.org/10.2298/APT1142063K
[7] Yavari, N., Assadi, M.M., Larijani, K. and Moghadam, M.B. (2010) Response Surface Methodology for Optimization of Glucuronic Acid Production Using Kombucha Layer on Sour Cherry Juice. Australian Journal of Basic and Applied Sciences, 4, 3250-3256.
[8] Sreeramulu, G., Zhu, Y. and Knol, W. (200) Kombucha Fermentation and Its Antimicrobial Activity. Journal of Agricultural and Food Chemistry, 48, 2589-2594.
http://dx.doi.org/10.1021/jf991333m
[9] Sreeramulu, G., Zhu, Y. and Knol, W. (2001) Characterization of Antimicrobial Activity in Kombucha Fermentation. Acta Biotechnologica, 21, 49-56.
http://dx.doi.org/10.1002/1521-3846(200102)21:1<49::AID-ABIO49>3.0.CO;2-G
[10] Greenwalt, C.-J., Steinkraus, K.-H. and Ledford, R.-A. (200) Kumbucha, the Fermented Tea: Microbiology, Composition, and Claimed Health Effect. Journal of Food Protection, 63, 976-981.
[11] Andrades, P., Sepúlveda, S. and González, J. (2004) Curación avanzada de heridas. Revista Chilena de Cirugía, 56, 396-403.
[12] Rodrígue, M.G.Q., Sotolongo Baró, M.C., álvarez, R.Q., Corral Salvadó, A. and Batista Veranes, M. (2001) Crema epitelizante de clorofila, carotenos y vitaminas aplicada en heridas abiertas experimentales. Revista Cubana de Medicina Militar, 30, 236-240.
[13] Espino Otero, S., Rodríguez, J.R., Mejías, Y.B., Sierra, O.A., Hijano, I.Q. and Selme, P. (2009) Concordancia clínico-istopatológica en lesiones de cabeza y cuello. MediSur, 7, 25-29.
[14] Veldhoen, M. and Stockinger, B. (2009) TGFβ1, a ‘Jack of All Trades’: The Link with Pro-Inflammatory IL-17-Producing T Cells. Trends in Immunology, 27, 358-361.
http://dx.doi.org/10.1016/j.it.2006.06.001
[15] Kwon, Y.B., Kim, H.W., Roh, D.H., Yoon, S.Y., Baek, R.M., Kim, J.Y., Kweon, H.Y., Lee, K.G., Park, Y.H. and Lee, J.H. (2006) Topical Application of Epidermal Growth Factor Accelerates Wound Healing by Myofibroblast Proliferation and Collagen Synthesis in Rat. Journal of Veterinary Science, 7, 105-109.
http://dx.doi.org/10.4142/jvs.2006.7.2.105
[16] Valencia Basto, C. (2010) Cicatrización: Proceso de reparación tisular, aproximaciones terapéuticas. Investigaciones Andina, 12, 58-89.
[17] Wang, J.F., Jiao, H., Stewart, T.L., Shankowsky, H.A., Scott, P.G. and Tredget, E.E. (2007) Fibrocytes from Burn Patients Regulate the Activities of Fibroblasts. Wound Repair and Regeneration, 15, 113-121.
http://dx.doi.org/10.1111/j.1524-475X.2006.00192.x

  
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