Share This Article:

The Antihypertensive Effect of ASA Lasts Less than 24 Hours?

Abstract Full-Text HTML XML Download Download as PDF (Size:331KB) PP. 62-70
DOI: 10.4236/wjcd.2015.53009    4,398 Downloads   4,780 Views   Citations

ABSTRACT

Objectives: Some studies suggest that acetylsalicylic acid (ASA) administered in the evening may have a lowering effect on the blood pressure. The purpose of this study was to measure the effect of the time of ASA administration on blood pressure, markers of arterial stiffness as well as various plasma parameters. Methods and Results: The study included 34 patients (20 men and 14 women) ranging in age from 47 to 82 years. Low-dose ASA (50 - 250 mg/day) was used by all the patients, first in the morning and later in the evening for three months. Home, office and ambulatory blood pressure and pulse wave velocity (PWV) were measured. Compared with the morning administration of ASA, significantly lower office systolic blood pressure (p = 0.017) and significantly higher carotid-femoral PWV (p = 0.010) as well as plasma triglycerides (p = 0.002) were found after the evening administration. There were no statistically significant changes in the average ambulatory blood pressure values, carotid-radial PWV or other parameters measured. However, the time of ASA administration seemed to affect the circadian variation in blood pressure. Conclusions: The results suggest that ASA administration may lower blood pressure, but for less than 24 hours. Our results should be verified by larger, randomized studies.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Suomela, I. , Varis, J. and Kantola, I. (2015) The Antihypertensive Effect of ASA Lasts Less than 24 Hours?. World Journal of Cardiovascular Diseases, 5, 62-70. doi: 10.4236/wjcd.2015.53009.

References

[1] de Gaetano, G. (2001) Collaborative Group of the Primary Prevention Project. Low-Dose Aspirin and Vitamin E in People at Cardiovascular Risk: A Randomized Trial in General Practice. Lancet, 357, 89-95.
http://dx.doi.org/10.1016/S0140-6736(00)03539-X
[2] Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A., Alonso, I., Silva, I., et al. (1999) Administration Time-Dependent Effects of Aspirin in Women at Differing Risk for Pre-Eclampsia. Hypertension, 34, 1016-1023.
http://dx.doi.org/10.1161/01.HYP.34.4.1016
[3] Hermida, R.C., Ayala, D.E., Iglesias, M. and Halberg, F. (1994) Time-Dependent Effects of ASA Administration on Blood Pressure in Healthy Subjects. Chronobiologia, 21, 201-213.
[4] Hermida, R.C., Mojón, A. and Fernandez, J.R. (2009) Ambulatory Blood Pressure Control with Bedtime Administration in Subjects with Prehypertension. American Journal of Hypertension, 22, 896-903.
http://dx.doi.org/10.1038/ajh.2009.83
[5] Hermida, R.C., Calvo, C., Ayala, D.E., Dóminguez, M.J., Covelo, M., Férnandez, J.R., et al. (2003) Administration Time-Dependent Effects of Aspirin on Blood Pressure in Untreated Hypertensive Patients. Hypertension, 41, 1259-1267.
http://dx.doi.org/10.1161/01.HYP.0000072335.73748.0D
[6] Hermida, R.C., Calvo, C. and Lopez, J.E. (2005) Aspirin Administered at Bedtime, But Not on Awakening, Has an Effect on Ambulatory Blood Pressure in Hypertensive Patients. Journal of the American College of Cardiology, 46, 975-983.
http://dx.doi.org/10.1016/j.jacc.2004.08.071
[7] Hermida, R.C., Calvo, C., Ayala, J.E., Mojón, A., Rodriguez, M., Chayán, L., et al. (2005) Differing Administration Time-Dependent Effects of Aspirin on Blood Pressure in Dipper and non-Dipper Hypertensives. Hypertension, 46, 1060-1068.
http://dx.doi.org/10.1161/01.HYP.0000172623.36098.4e
[8] Dimitrov, Y., Baguet, J.-P., Hottelart, C., Marboeuf, P., Tartiere, J.-M., Ducher, M. and Fauvel, J.-P. (2012) Is There a BP Benefit of Changing the Time of Aspirin Administration in Treated Hypertensive Patients? European Journal of Cardiovascular Prevention & Rehabilitation, 19, 706-711.
http://dx.doi.org/10.1177/1741826711418165
[9] Bonten, T.N., Snoep, J.D., Assendelft, W., Zwaginga, J.J., Eikenboom, J., Huisman, M.V., et al. (2015) Time-Dependent Effects of Aspirin on Blood Pressure and Morning Platelet Activity. A Randomized Cross-Over Trial. Hypertension.
[10] Lafeber, M., Grobbee, D.E., Schrover, I.M., Thom, S., Webster, R., et al. (2014) Comparison of a Morning Polylpill, Evening Polypill and Insividual Pills on LDL-Cholesterol, Ambulatory Blood Pressure and Adherence in High-Risk Patients; a Randomized Cross-Over Trial. International Journal of Cardiology, 181C, 193-199.
[11] Blacher, J., Asmar, R., Djane, S., London, G.M. and Safar, M.E. (1999) Aortic Pulse Wave Velocity as a Marker of Cardiovascular Risk in Hypertensive Patients. Hypertension, 33, 1111-1117.
http://dx.doi.org/10.1161/01.HYP.33.5.1111
[12] Millasseau, S.C., Ritter, J.M., Takazawa, K. and Chowienczyk, P.J. (2006) Contour Analysis of the Photoplethysmographic Pulse Measured at the Finger. Journal of Hypertension, 24, 1449-1456.
http://dx.doi.org/10.1097/01.hjh.0000239277.05068.87
[13] Chowienczyk, P.J., Kelly, R.P., MacCallum, H., Millasseau, S.C., Andersson, T.L., Gosling, R.G., Ritter, J.M. and Anggard, E.E. (1999) Photoplethysmographic Assessment of Pulse Wave Reflection: Blunted Response to Endothelium-Dependent β2-Adrenergic Vasodilation in Type II Diabetes Mellitus. Journal of the American College of Cardiology, 34, 2007-2014.
http://dx.doi.org/10.1016/S0735-1097(99)00441-6
[14] Sollinger, D., Mohaupt, M.G., Wilhelm, A., Uehlinger, D., Frey, F.J. and Eisenberger, U. (2006) Arterial Stiffness Assessed by Digital Volume Pulse Correlates with Comorbidity in Patients with ESRD. American Journal of Kidney Diseases, 48, 456-463.
http://dx.doi.org/10.1053/j.ajkd.2006.05.014
[15] Woodman, R.J., Kingwell, B.A., Beilin, L.J., Hamilton, S.E., Dart, A.M. and Watts, G.F. (2005) Assessment of Central and Peripheral Arterial Stiffness: Studies Indicating the Need to Use a Combination of Techniques. American Journal of Hypertension, 18, 249-260.
http://dx.doi.org/10.1016/j.amjhyper.2004.08.038
[16] Parati, G., Stergiou, G.S., Asmar, R., Bilo, G., deLeeuw, P., Imai, Y., et al. (2008) European Society of Hypertension Guidelines for Blood Pressure Monitoring at Home: A Summary Report of the Second International Consensus Conference on Home Blood Pressure Monitoring. Journal of Hypertension, 26, 1505-1530.
http://dx.doi.org/10.1097/HJH.0b013e328308da66

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.