Cryoablation-Induced Anti-Cancer Immune Reaction—Immune Reaction Induced By Cryoablation

Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Itaru Yasufuku, Ryuichi Asai, Yoshihisa Tokumaru, Takuji Sakuratani, Kazuhiro Yoshida

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Surgical Oncology, Gifu University School of Medicine, Yanagido, Gifu City, JAPAN..

DOI: 10.4236/jct.2011.22015                

Abstract

Among the ablation procedures used against advanced liver cancer, thermal ablation therapy is widely applied, and the safety and efficacy of this technique have been well characterized. In contrast, the principle of cryosurgery is not only to control local recurrence, but also to stimulate the immune system into initiating an anti-tumor response. In recent years, we have developed a treatment method for patients with advanced liver tumors. From these experiences, repeated treatment was demonstrated to induce anti-cancer immune reaction-related factors. In the present review, mechanisms for anti-tumor immune reaction will be argued with introducing a novel strategy of a cryoablation.

Keywords

Cryoablation, Helper T cell, Immune reaction, Hepatoma, Ablation therapy

Conflicts of Interest

The authors declare no conflicts of interest.

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