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The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study

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DOI: 10.4236/jbpc.2011.22016    5,743 Downloads   10,352 Views   Citations

ABSTRACT

The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Setzer, W. (2011) The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study. Journal of Biophysical Chemistry, 2, 135-136. doi: 10.4236/jbpc.2011.22016.

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