Share This Article:

Development of Melanoma and Cancer without Decreasing of Cambial Cells Number in Morphofunctional Zones

Abstract Full-Text HTML XML Download Download as PDF (Size:932KB) PP. 493-500
DOI: 10.4236/abb.2014.56059    3,471 Downloads   4,313 Views   Citations

ABSTRACT

In age groups from 20 to 60 years old, proliferation and differentiation of cells happen in a morphofunctional zone, in the electric field excited by 12 pairs of mother and daughter cells, turned out at cambial cells division. Thus in daughter cells the Src SH2 domain necessary both for cytoskeleton formation and tyrosinase activization is activated. If the conditions for strengthening of tyrosinase activity are created in organism, the portion of Src participating in the cytoskeleton building can decrease to critical level that will lead to development of a malignant tumor. If action of a stimulating factor is quite strong, proliferation of malignant cells begins at a stage of melanocyte, and a melanoma occurs. If action of factors is long and not strong, more remote descendants of daughter cells proliferate, and a cancer appears. In order that there will be a normal differentiation of malignantly changed daughter cells, it is necessary to block the tyrosinase. Thus all SH2 domains will go on cell cytoskeleton formation.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Yavisheva, T. and Shcherbakov, S. (2014) Development of Melanoma and Cancer without Decreasing of Cambial Cells Number in Morphofunctional Zones. Advances in Bioscience and Biotechnology, 5, 493-500. doi: 10.4236/abb.2014.56059.

References

[1] Yavisheva, T.M. and Shcherbakov, S.D. (2011) Characteristic Features of Proliferation and Differentiation of Cambial and Daughter Cells in Morphofunctional Zones in Normal Epithelium and Cancer in Age Aspect. Advances in Gerontology, 1, 50-56.
http://dx.doi.org/10.1134/S2079057011010140
[2] Yavisheva, T.M. and Shcherbakov, S.D. (2014) Morphofunctional Zones: Structure and Functions. LAMBERT Academic Publishing, Germany.
[3] Shchapova, A.I. (1971) About Structure of a Karyotype and an Order of the Arrangement of Chromosomes in the Interphase Nucleus. Tsytologia, 13, 1157-1163.
[4] Yavisheva, T.M. Shcherbakov, S.D., Golubeva, I.S., Savluchinskaya, L.A. and Rizhova, N.I. (2012) The Relationship between the Epidermal Melanocytes, Langerhans Cells and Epidermal Cambial Cells. International Journal of BioMedicine, 2, 228-231.
[5] White, A., Handler, P., Smith, E., Hill, R. and Lehman, I. (1981) Principles of Biochemistry. Mir, Moscow. (in Russian)
[6] Torchinsky, Yu.M. (1971) Sulphhydrile and Disulphide Groups. Nauka, Moscow.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.