Share This Article:

Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis

Abstract Full-Text HTML Download Download as PDF (Size:147KB) PP. 49-55
DOI: 10.4236/ojst.2014.42009    3,739 Downloads   5,183 Views   Citations

ABSTRACT

Chronic periodontitis (CP) and rheumatoid arthritis (RA) are chronic inflammatory conditions, and share many pathologic features. Plasma amino acid profiles have been shown to be associated with RA, but their relevance to CP remains unclear. The aim of the present study is to evaluate amino acid profiles in relation to CP and RA. The study participants consisted of 62 patients with RA (RA group), 30 patients with CP (CP group) and 29 healthy controls (H group) in age-, gender-, smoking status-balanced condition. Clinical periodontal and rheumatologic parameter values and plasma levels of 21 amino acids, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined. Multiple comparison analyses revealed that the RA group exhibited similar periodontal conditions but significantly higher levels of CRP, IL-6, and TNF-α than the CP group (P < 0.01). A total of four amino acids (glycine, histidine, ornithine, and alpha-aminobutyric acid) were significantly different in the concentrations among the three groups (P < 0.01). The RA group displayed significantly lower levels of glycine and histidine and significantly higher ornithine level than the CP and H groups (P < 0.01). The CP group showed significantly higher alpha-aminobutyric acid level than the RA and H groups (P < 0.01). Of these four amino acids, a significantly positive correlation was found between ornithine level and % of sites with bleeding on probing (P = 0.006) in the RA group. These results suggest a possibility that profiles of four amino acids may play a role in the pathogenesis of CP and RA.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kobayashi, T. , Okada, M. , Ito, S. , Kobayashi, D. , Shinhara, A. , Muramatsu, T. , Kobayashi, T. , Narita, I. , Nakazono, K. , Murasawa, A. and Yoshie, H. (2014) Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis. Open Journal of Stomatology, 4, 49-55. doi: 10.4236/ojst.2014.42009.

References

[1] Mercado, F.B., Marshall, R.I. and Bartold, P.M. (2003) Inter-relationship between rheumatoid arthritis and periodontal disease. A review. Journal of Clinical Periodontology, 30, 761-772.
http://dx.doi.org/10.1034/j.1600-051X.2003.00371.x
[2] de Pablo, P., Chapple, I.L.C., Buckley, C.D. and Dietrich, T. (2009) Periodontitis in systemic rheumatic diseases. Nature Reviews Rheumatology, 5, 218-224.
http://dx.doi.org/10.1038/nrrheum.2009.28
[3] Pischon, N., Pischon, T., Kröger, J., et al. (2008) Association among rheumatoid arthritis, oral hygiene, and periodontitis. Journal of Periodontology, 79, 979-986.
http://dx.doi.org/10.1902/jop.2008.070501
[4] Dissick, A., Redman, R.S., Jones, M., et al. (2010) Association of periodontitis with rheumatoid arthritis: A pilot study. Journal of Periodontology, 81, 223-230.
http://dx.doi.org/10.1902/jop.2009.090309
[5] Mercado, F., Marshall, R.I., Klestov, A.C. and Bartold, P.M. (2000) Is there a relationship between rheumatoid arthritis and periodontal disease? Journal of Clinical Periodontology, 27, 267-272.
http://dx.doi.org/10.1034/j.1600-051x.2000.027004267.x
[6] Demmer, R.T., Molitor, J.A., Jacobs Jr., D.R. and Michalowicz, B.S. (2011) Periodontal disease, tooth loss and incident rheumatoid arthritis: Results from the First National Health and Nutritional Examination Survey and its epidemiological follow-up study. Journal of Clinical Periodontology, 38, 998-1006.
http://dx.doi.org/10.1111/j.1600-051X.2011.01776.x
[7] Sørensen, L.K., Havemose-Poulsen, A., Bendtzen, K. and Holmstrup, P. (2009) Aggressive periodontitis and chronic arthritis: Blood mononuclear cell gene expression and plasma protein levels of cytokines and cytokine inhibitors. Journal of Periodontology, 80, 282-289.
http://dx.doi.org/10.1902/jop.2009.080347
[8] Kobayashi, T., Murasawa, A., Komatsu, Y., et al. (2010) Serum cytokine and periodontal profiles in relation to disease activity of rheumatoud arthritis in Japanese adults. Journal of Periodontology, 80, 650-657.
http://dx.doi.org/10.1902/jop.2010.090688
[9] Havemose-Poulsen, A., Sørensen, L.K., Bendtzen, K. and Holmstrup, P. (2007) Polymorphisms within the IL-1 gene cluster: Effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. Journal of Periodontology, 78, 475-492.
http://dx.doi.org/10.1902/jop.2007.060135
[10] Kobayashi, T., Ito, S., Kuroda, T., et al. (2007) The interleukin-1 and Fcγ receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis. Journal of Periodontology, 78, 2311-2318.
http://dx.doi.org/10.1902/jop.2007.070136
[11] Kobayashi, T., Murasawa, A., Ito, S., et al. (2009) Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. Journal of Periodontology, 80, 792-799.
http://dx.doi.org/10.1902/jop.2009.080573
[12] Madsen, R.K., Lundstedt, T., Gabrielsson, J., et al. (2011) Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Arthritis Research & Therapy, 13, R19.
http://dx.doi.org/10.1186/ar3243
[13] Madsen, R.K., Rantapää-Dahlqvist, S., Lundstedt, T., Moritz, T. and Trygg, J. (2012) Metabolic response to change in disease activity during tumor necrosis factor inhibition in patients with rheumatoid arthritis. Journal of Proteome Research, 11, 3796-3804.
http://dx.doi.org/10.1021/pr300296v
[14] Syrjänen, S., Piironen, P. and Markkanen, H. (1987) Free amino-acid content of wax-stimulated human whole saliva as related to periodontal disease. Archives of Oral Biology, 32, 607-610.
http://dx.doi.org/10.1016/0003-9969(87)90032-X
[15] Syrjänen, S., Alakuijala, L., Alakuijala, P., Markkanen, S.O. and Markkanen, H. (1990) Free amino-acid levels in oral fluids of normal subjects and patients with periodontal disease. Archives of Oral Biology, 35, 189-193.
http://dx.doi.org/10.1016/0003-9969(90)90054-E
[16] Arnett, F.C., Edworthy, S.M., Bloch, D.A., et al. (1988) The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis & Rheumatology, 31, 315-324.
http://dx.doi.org/10.1002/art.1780310302
[17] Esen, C., Alkan, B.A., Kirnap, M., Akgül, Ö., Isikoglu, S. and Erel, Ö. (2012) The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. Journal of Periodontology, 83, 773-779.
http://dx.doi.org/10.1902/jop.2011.110420
[18] Inoue, E., Yamanaka, H., Hara, M., Tomatsu, T. and Kamatani, N. (2007) Comparison of disease activity score (DAS) 28-erythrocyte sedimentation rate and DAS28-C-reactive protein threshold values. Annals of the Rheumatic Diseases, 66, 407-409.
http://dx.doi.org/10.1136/ard.2006.054205
[19] Shimbo, K., Kubo, S., Harada, Y., et al. (2010) Auto- mated precolumn derivatization system for analyzing physiological amino acids by liquid chromatography/ mass spectrometry. Biomedical Chromatography, 24, 683-691.
http://dx.doi.org/10.1002/bmc.1346
[20] Yamanaka, H., Inoue, E., Singh, G., et al. (2007) Improvement of disease activity of rheumatoid arthritis patients from 2000 to 2006 in a large observational cohort study IORRA in Japan. Modern Rheumatology, 17, 283-289.
http://dx.doi.org/10.1007/s10165-007-0587-6
[21] Matsui, T., Kuga, Y., Kaneko, A., et al. (2007) Disease activity score 28 (DAS28) using C-reactive protein underestimates disease activity and overestimates EULAR response criteria compared with DAS28 using erythrocyte sedimentation rate in a large observational cohort of rheumatoid arthritis patients in Japan. Annals of the Rheumatic Diseases, 66, 1221-1226.
http://dx.doi.org/10.1136/ard.2006.063834
[22] Davis, J.S., Darcy, C.J., Piera, K., McNeil, Y.R., Woodberry, T. and Anstey, N.M. (2009) Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: Implications for arginine and taurine measurements. BMC Clinical Pathology, 9, 10.
http://dx.doi.org/10.1186/1472-6890-9-10
[23] Sittons, N.G., Dixon, J.S., Astbury, C., Francis, R.J., Bird, H.A. and Wright, V. (1988) Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthritis. Annals of the Rheumatic Diseases, 47, 48-52.
http://dx.doi.org/10.1136/ard.47.1.48
[24] Jones, M.G., Cooper, E., Amjad, S., Goodwin, C.S., Barron, J.L. and Chalmers, R.A. (2005) Urinary and plasma organic acids and amino acids in chronic fatigue syndrome. Clinica Chimica Acta, 361, 150-158.
http://dx.doi.org/10.1016/j.cccn.2005.05.023
[25] Chiarla, C., Giovannini, I. and Siegel, J.H. (2011) Characterization of alpha-amino-n-butyric acid correlations in sepsis. Translational Research, 158, 328-333.
http://dx.doi.org/10.1016/j.trsl.2011.06.005

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.