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Antioxidants: Friend or foe for tuberculosis patients

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DOI: 10.4236/abb.2013.411A2002    3,766 Downloads   6,321 Views   Citations

ABSTRACT

Respiratory burst induced bacteria killing by oxidants are important mechanism of host defence. However, it is impaired in tuberculosis due to inhibition of respiratory burst by Mycobacterial factors. Antioxidants are compounds that cause chelation of reactive oxygen species. So, antioxidants are expected to play a negative role in the management of active tuberculosis. But, oxidative stress is a proved fact that invariably happens in tuberculosis patients which is known to cause immunosuppression. Immunosuppression in turn is expected to augment tuberculosis. Hence, antioxidant supplementation is expected to benefit tuberculosis patients by minimising oxidative stress induced immunosuppression. Therefore, the role of antioxidants in tuberculosis appears to be paradoxical and urgent. Understanding of the role of antioxidant supplementation in tuberculosis is warranted. It is in this context that we have reviewed the recent literature and addressed the problem for its solution.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Bhattacharyya, R. and Banerjee, D. (2013) Antioxidants: Friend or foe for tuberculosis patients. Advances in Bioscience and Biotechnology, 4, 10-14. doi: 10.4236/abb.2013.411A2002.

References

[1] Villanueva, C. and Kross, R.D. (2012) Antioxidant induced stress. International Journal of Molecular Science, 13, 2091-2109. http://dx.doi.org/10.3390/ijms13022091
[2] Kinchen, J.M. and Ravichandran, K.S. (2008) Phagosome maturation: Going through the acid test. Nature Reviews Molecular Cell Biology, 9, 781-795.
http://dx.doi.org/10.1038/nrm2515
[3] Miller, B.H., Fratti, R.A., Poschet, J.F., et al. (2004) Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection. Infection and Immunity, 72, 2872-2878.
http://dx.doi.org/10.1128/IAI.72.5.2872-2878.2004
[4] Lee, P.P., Chan, K.W., Jiang, L., et al. (2008) Susceptibility to mycobacterial infections in children with X-linked chronic granulomatous disease: A review of 17 patients living in a region endemic for tuberculosis. The Pediatric Infectious Disease Journal, 27, 224-230.
http://dx.doi.org/10.1097/INF.0b013e31815b494c
[5] Botti, H., Batthyány, C., Trostchansky, A., et al. (2004) Peroxynitrite-mediated alpha-tocopherol oxidation in low-density lipoprotein: A mechanistic approach. Free Radical Biology and Medicine, 36, 152-162.
http://dx.doi.org/10.1016/j.freeradbiomed.2003.10.006
[6] Maguire, J.J., Wilson, D.S. and Packer, L. (1989) Mitochondrial electron transport-linked tocopheroxyl radical reduction. Journal of Biological Chemistry, 264, 21462-21465.
[7] Damiani, E., Astolfi, P., Carloni, P., Stipa, P. and Greci, L. (2008) Antioxidants: How they work. In: Valacchi, G. and Davis, P.A., Eds., Oxidants in Biology, Springer Science Buisness Media, New York, 251-266.
http://dx.doi.org/10.1007/978-1-4020-8399-0_12
[8] Duracková, Z. (2008) Oxidants, antioxidants and oxidative stress. In: Gvozdjáková, A., Ed., Mitochondrial Medicine, Springer Science Business Media, New York, 19-54. http://dx.doi.org/10.1007/978-1-4020-6714-3_2
[9] Liu, C., Russell, R.M. and Wang, X.D. (2004) Alphatocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro. Journal of Nutrition, 134, 426-430.
[10] Yeum, K.J., Aldini, G., Russell, R.M. and Krinsky, N.I. (2009) Carotenoids, Vol. 5, Birkhäuser Verlag, Basel, 235-268.
[11] Vergne, I., Chua, J. and Deretic, V. (2003) Mycobacterium tuberculosis phagosome maturation arrest: Selective targeting of PI3P-dependent membrane trafficking. Traffic, 4, 600-606.
http://dx.doi.org/10.1034/j.1600-0854.2003.00120.x
[12] Puri, R.V., Reddy, P.V. and Tyagi, A.K. (2013) Secreted acid phosphatase (SapM) of mycobacterium tuberculosis eIs indispensable for arresting phagosomal maturation and growth of the pathogen in guinea pig tissues. PLoS One, 8, e70514.
http://dx.doi.org/10.1371/journal.pone.0070514
[13] Luo, M., Fadeev, E.A. and Groves, J.T. (2005) Mycobactin-mediated iron acquisition within macrophages. Nature Chemical Biology, 1, 149-153.
http://dx.doi.org/10.1038/nchembio717
[14] Banerjee, D., Bhattacharyya, R., Kaul, D. and Sharma, P. (2011) Diabetes and tuberculosis: Analysis of a paradox. Advance in Clinical Chemistry, 53, 139-153.
[15] Bhattacharyya, R. and Banerjee, D. (2011) Glycation of calmodulin binding domain of iNOS may increase the chance of occurrence of tuberculosis in chronic diabetic state. Bioinformation, 7, 324-327.
http://dx.doi.org/10.6026/97320630007324
[16] Trivedi, A., Singh, N., Bhat, S.A., Gupta, P. and Kumar, A. (2012) Redox biology of tuberculosis pathogenesis. Advances in Microbial Physiology, 60, 263-324.
http://dx.doi.org/10.1016/B978-0-12-398264-3.00004-8
[17] Braunstein, M., Espinosa, B.J., Chan, J., Belisle, J.T. and Jacobs Jr., W.R. (2003) SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis. Molecular Microbiology, 48, 453-464. http://dx.doi.org/10.1046/j.1365-2958.2003.03438.x
[18] Piddington, D.L., Fang, F.C., Laessig, T., Cooper, A.M., Orme, I.M. and Buchmeier, N.A. (2001) Cu, Zn superoxide dismutase of Mycobacterium tuberculosis contributes to survival in activated macrophages that are generating an oxidative burst. Infection and Immunity, 69, 4980-4987.
http://dx.doi.org/10.1128/IAI.69.8.4980-4987.2001
[19] Sao Emani, C., Williams, M.J., Wiid, I.J., Hiten, N.F., Viljoen, A.J., Pietersen, R.D., van Helden, P.D. and Baker, B. (2013) Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis. Antimicrobial Agents and Chemotherapy, 57, 3202-3207.
http://dx.doi.org/10.1128/AAC.02572-12
[20] Gurumurthy, M., Rao, M., Mukherjee, T., Rao, S.P., Boshoff, H.I., Dick, T., Barry, C.E. 3rd and Manjunatha, U.H. (2013) A novel F(420)-dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents. Molecular Microbiology, 87, 744-755. http://dx.doi.org/10.1111/mmi.12127
[21] Saikolappan, S., Das, K., Sasindran, S.J., Jagannath, C. and Dhandayuthapani, S. (2011) OsmC proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis protect against organic hydroperoxide stress. Tuberculosis, 91, S119-S127.
http://dx.doi.org/10.1016/j.tube.2011.10.021
[22] Jain, R., Dey, B., Khera, A., Srivastav, P., Gupta, U.D., Katoch, V.M., Ramanathan, V.D. and Tyagi, A.K. (2011) Over-expression of superoxide dismutase obliterates the protective effect of BCG against tuberculosis by modulating innate and adaptive immune responses. Vaccine, 29, 8118-8125. http://dx.doi.org/10.1016/j.vaccine.2011.08.029
[23] De Groote, M.A., Ochsner, U.A., Shiloh, M.U., et al. (1997) Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proceedings of the National Academy of Science of United States of America, 94, 13997-4001. http://dx.doi.org/10.1073/pnas.94.25.13997
[24] Frohner, I.E., Bourgeois, C., Yatsyk, K., Majer, O. and Kuchler, K. (2009) Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Molecular Microbiology, 71, 240-252.
http://dx.doi.org/10.1111/j.1365-2958.2008.06528.x
[25] Youseff, B.H., Holbrook, E.D., Smolnycki, K.A. and Rappleye, C.A. (2012) Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress. PLoS Pathogens, 8, e1002713.
http://dx.doi.org/10.1371/journal.ppat.1002713
[26] Oberley-Deegan, R.E., Rebits, B.W., Weaver, M.R., et al. (2010) An oxidative environment promotes growth of Mycobacterium abscessus. Free Radical Biology and Medicine, 49, 1666-1673.
http://dx.doi.org/10.1016/j.freeradbiomed.2010.08.026
[27] Oberley-Deegan, R.E., Lee, Y.M., Morey, G.E., Cook, D.M., Chan, E.D. and Crapo, J.D. (2009) The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. American Journal of Respiratory Cell and Molecular Biology, 41, 170-178.
http://dx.doi.org/10.1165/rcmb.2008-0138OC
[28] Guerra, C., Morris, D., Sipin, A., et al. (2011) Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals. PLoS One, 6, e28378.
http://dx.doi.org/10.1371/journal.pone.0028378
[29] Morris, D., Khurasany, M., Nguyen, T., et al. (2013) Glutathione and infection. Biochimica et Biophysica Acta, 1830, 3329-3349.
http://dx.doi.org/10.1016/j.bbagen.2012.10.012
[30] Manni, M.L., Tomai, L.P., Norris, C.A., et al. (2011) Extracellular superoxide dismutase in macrophages augments bacterial killing by promoting phagocytosis. The American Journal of Pathology, 178, 2752-2759.
http://dx.doi.org/10.1016/j.ajpath.2011.02.007
[31] Palanisamy, G.S., Kirk, N.M., Ackart, D.F., et al. (2011) Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis. PLoS One, 6, e26254. http://dx.doi.org/10.1371/journal.pone.0026254
[32] Dalvi, S.M., Patil, V.W., Ramraje, N.N., Phadtare, J.M. and Gujarathi, S.U. (2013) Nitric oxide, carbonyl protein, lipid peroxidation and correlation between antioxidant vitamins in different categories of pulmonary and extra pulmonary tuberculosis. The Malaysian Journal of Medical Sciences, 20, 21-30.
[33] Dalvi, S.M., Patil, V.W. and Ramraje, N.N. (2012) The roles of glutathione, glutathione peroxidase, glutathione reductase and the carbonyl protein in pulmonary and extra pulmonary tuberculosis. Journal of Clinical and Diagnostic Research, 6, 1462-1465.
[34] Hemilä, H. and Kaprio J. (2009) Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C. American Journal of Epidemiology, 169, 946-953.
http://dx.doi.org/10.1093/aje/kwn413
[35] Hemilä, H. and Kaprio, J. (2008) Vitamin E supplementation may transiently increase tuberculosis risk in males who smoke heavily and have high dietary vitamin C intake. The British Journal of Nutrition, 100, 896-902.
http://dx.doi.org/10.1017/S0007114508923709
[36] Hemilä, H. and Kaprio, J. (2008) Vitamin E supplementation and pneumonia risk in males who initiated smoking at an early age: Effect modification by body weight and dietary vitamin C. Nutrition Journal, 7, 33.
http://dx.doi.org/10.1186/1475-2891-7-33
[37] Zhang, Z.W., Wang, Q.H., Zhang, J.L., Li, S., Wang, X.L. and Xu, S.W. (2012) Effects of oxidative stress on immuno-suppression induced by selenium deficiency in chickens. Biological Trace Element Research, 149, 352-361. http://dx.doi.org/10.1007/s12011-012-9439-0
[38] Efimova, O., Szankasi, P. and Kelley, T.W. (2011) Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells. PLoS One, 6, e16013. http://dx.doi.org/10.1371/journal.pone.0016013
[39] Naviaux, R.K. (2012) Oxidative shielding or oxidative stress? The Journal of Pharmacology and Experimental Therapeutics, 342, 608-618.
http://dx.doi.org/10.1124/jpet.112.192120
[40] Lian, Y., Zhao, J. and Xu, P. (2013) Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice. PLoS One, 8, e72058.
http://dx.doi.org/10.1371/journal.pone.0072058
[41] Ergul, Y., Erkan, T., Uzun, H., Genc, H., Altug, T. and Erginoz, E. (2010) Effect of vitamin C on oxidative liver injury due to isoniazid in rats. Pediatrics International, 52, 69-74.
http://dx.doi.org/10.1111/j.1442-200X.2009.02891.x

  
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