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Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung Cancer

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DOI: 10.4236/eng.2012.410B042    2,870 Downloads   3,627 Views  

ABSTRACT

Object: To explore the therapeutic effects and therapeutic mechanisms of Conditional Replication Adenovirus(CRAd) in combination with cisplatin on lung cancer cells. Methods: Using MTS / PMS assay, in vitro cell inhibition assay was performed to detect the cell viability of two lung cancer cell lines, NCI-H292 and NCI-H661. PCR was employed to detect the Coxsackie receptor(CAR) expression of cancer cells. The in vivo anti-tumor effect of CRAd and cisplatin was evaluated using a subcutaneous mouse model. Results: The CRAd with cisplatin is superior to the use of cisplatin or CRAd viruse alone on the suppression of lung cancer cell growth. The mechanism of inhibition is associated with the increased CAR expression. Conclusion: The application of CRAd in combination with cisplatin could play a better therapeutic effect on lung cancer cell growth inhibition.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Y. Liu and Y. Huang, "Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung Cancer," Engineering, Vol. 4 No. 10B, 2012, pp. 163-164. doi: 10.4236/eng.2012.410B042.

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