A Report of 2 Cases of Disseminated Invasive Aspergillosis with Myocarditis in Immunocompromised Patients

Tetsuhiro Yoshino, Hiroko Nishida, Takashi Takita, Masanori Nemoto, Michihiro Sakauchi, Mami Hatano, Kazuyuki Koyama, Masao Hori, Katsuyuki Obara

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Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

DOI: 10.4236/ojpathology.2013.34030                

Abstract

Invasive aspergillosis is a life-threatening opportunistic infection that occurs most often in immunocompromised patients, especially those with either hematological malignancies treated with chemotherapy or in organ transplant recipients. Here, we report 2 cases of disseminated invasive aspergillosis with myocarditis proven pathologically by autopsy. These 2 cases occurred in immunocompromised patients: the first patient received chemotherapy for acute myeloid leukemia with myelodysplasia-related changes (AML-MRC); the second patient received methotrexate therapy for rheumatoid arthritis (RA). Invasive aspergillosis with myocarditis has high morbidity and mortality rates, therefore it is necessary to make prompt diagnosis and to start intensive treatments quickly.

Keywords

Invasive Aspergillosis; Myocarditis; Acute Myeloid Leukemia; Rheumatoid Arthritis

Conflicts of Interest

The authors declare no conflicts of interest.

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