Fever of unknown origin as the first manifestation of Erdheim-Chester disease

Ning Li, Mingquan Chen, Huaping Sun, Yun Bao, Jiming Zhang

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China;.
Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.

DOI: 10.4236/crcm.2013.26095                

Abstract

Erdheim-Chester disease (ECD) is an uncommon non-Langerhans cell histiocytosis that affects multiple body systems and can present clinically in a myriad of ways. We report the case of a 29-year-old man presented with fever and diffuse bone pain. Physical examination showed bilateral and symmetrical long bone pain, especially the knees. Radiographs showed multiple mixed bone lesions with sclerotic and lytic areas of the femora, tibiae, and fibula. Biopsy of the tibial area displayed foamy lipid-laden histiocytes, confirming the diagnosis of ECD.

Keywords

Erdheim-Chester Disease; Histiocytosis; Osteoarthropathy

Conflicts of Interest

The authors declare no conflicts of interest.

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