Oxaliplatin induced hyperexcitability syndrome in patient with appendiceal adenocarcinoma

Nicola Jabbour, Maher Alchreiki, Mohammad Hussain

Harlan ARH Hospital, Harlan, USA.
Hazard ARH Cancer Center, Hazard, USA.
Johnson Medical Center, Smithfield, USA;.

DOI: 10.4236/crcm.2013.24064                

Abstract

Oxaliplatin is a novel platinum compound with clinical activity against several solid tumors. It has been associated with sensory neuropathies and, rarely, a neuromyotonia-like hyperexcitability syndrome; a form of peripheral neuropathy manifested by tremor and twitching activity of muscles. We present a case of hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.

Keywords

Oxaliplatin; Peripheral Neuropathy; Neuromyotonia; Hyperexcitability Syndrome; Appendiceal Adenocarcinoma; Sodium Channels

Conflicts of Interest

The authors declare no conflicts of interest.

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