[1-(4-Nitrobenzyl)-2-butyl-4-chloro-1H-imidazol-5-yl]-4, 5-dihydro-1-phenyl-1H-pyrazole: Synthesis, Anti-Inflammatory and Analgesic Activities

S. Sreenivasa, B. J. Shankar

Department of Studies and Research in Chemistry, Tumkur University, Tumkur, India.

DOI: 10.4236/ojmc.2013.32007                

Abstract

In the present investigation, series of Bis (heterocycle)s bearing pyrazoline in combination of the imidazole derivatives have been synthesized via 1,3-dipolar cycloaddition reactions of N-(nitrobenzyl)-imidazole nitrile imines with different dipolarophiles. All the newly synthesized compounds were characterized and screened for analgesic-anti-inflammatory activities and were compared with the standard drugs. The compounds exhibited excellent anti-inflammatory and analgesic activities. Out of the compounds studied 4b, 4d and 4g compounds shown statistically significant activity comparable to the standard drugs Ibuprofen and Aspirin at the same dose.

Keywords

Anti-Inflammatory; Analgesic; N-(nitrobenzyl)-imidazole aldehyde; Chloramine-T

Conflicts of Interest

The authors declare no conflicts of interest.

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