Modelling One-Pot Method for Synthesis of 2,3-Dihydro-1H-pyrrolo[2,1-c][1,4]benzothiazine 5,5-Dioxides and Their Homologues

Oleksandr Yu Grevtsov, Oleg V. Zaremba, Anna B. Bondarenko, Oleksandr G. Drushlyak, Sergiy M. Kovalenko, Valentyn P. Chernykh

National University of Pharmacy, Kharkiv, Ukraine.

DOI: 10.4236/ijoc.2013.32014                

Abstract

A facile method for synthesis of 2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzothiazines by interaction of methylenactive (2-fluorophenyl)sulfones with homologues of either 5-methoxy-3,4-dihydro-2H-pyrrole or 5-(methylthio)-3,4-dihydro- 2H-pyrrole has been developed.

Keywords

Sulfones; Lactims; Cyclization; Heterocycles; Nucleophilic Aromatic Substitution

Conflicts of Interest

The authors declare no conflicts of interest.

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