Angiomyofibroblastoma of the vulva: A case report with literature review

Jung Ho Park, Mi Kyung Shin, Maria Lee, Sung Taek Park, Sung-Ho Park, Hong-Bae Kim

Department of Obstetrics & Gynecology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
Department of Obstetrics & Gynecology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea;.
Department of Pathology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
Hallym University Collage of Medicine, Chuncheon, Korea.

DOI: 10.4236/crcm.2013.23060                

Abstract

Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evaluation is performed to rule out perineal hernia and invasive neoplasm. Like other benign mesenchymal tumors of vulva, AMF shows indolent behavior and rarely recurs after complete surgical excision.

Keywords

Angiomyofibroblastoma; Vulvar Neoplasm

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Fletcher, C.D., Tsang, W.Y., Fisher, C., Lee, K.C. and Chan, J.K. (1992) Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. The American Journal of Surgical Pathology, 16, 373-382. doi:10.1097/00000478-199204000-00006
[2]	Kimihiro, N., Koji, A. and Hitoaki, S. (2010) Huge pedunculated angiomyofibroblastoma of the vulva. International Journal of Clinical Oncology, 15, 201-205. doi:10.1007/s10147-010-0026-0
[3]	Magro, G., Caltabiano, R., Kacerovská, D., Vecchio, G.M., Kazakov, D. and Michal, M. (2012) Vulvovaginal myofibroblastoma: Expanding the morphological and immunohistochemical spectrum. A clinicopathologic study of 10 cases. Human Pathology, 43, 243-253. doi:10.1016/j.humpath.2011.04.027
[4]	Amezcua, C.A., Begley, S.J., Mata, N., Felix, J.C. and Ballard, C.A. (2005) Aggressive angiomyxoma of the female genital tract: A clinicopathologic and immuno-histochemical study of 12 cases. International Journal of Gynecological Cancer, 15, 140-145. doi:10.1111/j.1048-891x.2005.15015.x
[5]	Magtibay, P.M., Salmon, Z., Keeney, G.L. and Podratz, K.C. (2006) Aggressive angiomyxoma of the female pelvis and perineum: A case series. International Journal of Gynecological Cancer, 16, 396-401. doi:10.1111/j.1525-1438.2006.00225.x
[6]	Chan, Y.M., Hon, E., Ngai, S.W., Ng, T.Y. and Wong, L.C. (2000) Aggressive angiomyxoma in females: Is radical resection the only option? Acta Obstetricia et Gynecologica Scandinavica, 79, 216-220. doi:10.1080/j.1600-0412.2000.079003216.x
[7]	Mortele, K.J., Lauwers, G.J., Mergo, P.J. and Ros, P.R. (1999) Perineal angiomyofibroblastoma: CT and MR findings with pathologic correlation. Journal of Computer Assisted Tomography, 23, 687-689. doi:10.1097/00004728-199909000-00007
[8]	Kim, S.W., Lee, J.H., Han, J.K. and Jeon, S. (2009) Angiomyofibroblastoma of the vulva: Sonographic and computed tomographic findings with pathologic correlation. Journal of Ultrasound in Medicine, 28, 1417-1420.
[9]	Granter, S.R., Nucci, M.R. and Fletcher, C.D. (1997) Aggressive angiomyxoma: Reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology, 30, 3-10. doi:10.1046/j.1365-2559.1997.d01-556.x
[10]	Laskin, W.B., Fetsch, J.F. and Mostofi, F.K. (1998) Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 22, 6-16. doi:10.1097/00000478-199801000-00002
[11]	Medeiros, F., Erickson-Johnson, M.R., Keeney, G.L., Clayton, A.C., Nascimento, A.G., Wang, X. and Oliveira, A.M. (2007) Frequency and characterization of HMGA2 and HMGA1 rearrangements in mesenchymal tumors of the lower genital tract. Genes Chromosomes Cancer, 46, 981-990. doi:10.1002/gcc.20483