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Antibody fragments: Prolonging circulation half-life special issue-antibody research

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DOI: 10.4236/abb.2013.45090    8,744 Downloads   14,107 Views   Citations


Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and antibody-like fragments are being evaluated clinically. Production of antibody fragments can be efficient and their compact size can allows for better tissue extravasation into solid tumors than full antibodies. Unfortunately, a key limitation of antibody fragments for systemic use is their short half-life in circulation. Prolonging their circulation half-life can be accomplished clinically by the covalent conjugation of the antibody fragment to the water-soluble polymer, poly(ethylene glycol) (PEG). Many polymers and strategies are also being pursued to increase antibody fragment half-life.

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The authors declare no conflicts of interest.

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Herrington-Symes, A. , Farys, M. , Khalili, H. and Brocchini, S. (2013) Antibody fragments: Prolonging circulation half-life special issue-antibody research. Advances in Bioscience and Biotechnology, 4, 689-698. doi: 10.4236/abb.2013.45090.


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