Share This Article:

A paradigm for a skin graft substitute

DOI: 10.4236/ojrm.2013.22005    3,737 Downloads   5,958 Views  

ABSTRACT

Skin grafts have remained relatively unchanged since their introduction as a medical treatment for burns/wounds. This paper seeks to open an academic discussion as to whether their use-by date has now been passed. A skin graft substitute is described in a paradigm using fine leaf gelatine sheets which inherently possess several distinct advantages including, discarding the harvest of autologous tissue from patient donor sites. A clinical study will be needed to determine its suitability taken together with the understanding that experimental animal studies may not provide unequivocal answers to its in situ modus operandi.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Solomon, D. (2013) A paradigm for a skin graft substitute. Open Journal of Regenerative Medicine, 2, 28-30. doi: 10.4236/ojrm.2013.22005.

References

[1] Reverdin, J.L. (1869) Greffes epidermiques. Bulletin de la Societe Imperiale de Chirurgie de Paris, 10, 51.
[2] Blair, V.P. and Brown, J.B. (1929) The use and uses of large split skin grafts of intermediate thickness. Surgery, Gynecology & Obstetrics, 49, 82.
[3] Shimizu, R. and Kishi, K. (2012) Skin graft. Plastic Surgery International, 2012, 563493.
[4] Solomon, D.E. (2012) Mimicry of a natural, living intra-epidermal micro pattern used in guided tissue regeneration of the human epidermis. Journal of Developmental Biology and Tissue Engineering, 4, 1-7.
[5] Modernist Pantry, Magical Ingredients for the Modern Cook, York, USA. www.modernistpantry.com/gelatin-sheets-silver.html
[6] Turing, A.M. (1950) Computing machinery and intelligence. Mind, 236, 433-460.
[7] Metcalfe, A.D. and Ferguson, M.W. (2007) Bioengineering skin using mechanisms of regeneration and repair. Biomaterials, 28, 5100-5113. doi:10.1016/j.biomaterials.2007.07.031
[8] Carbone, A.C. (2004) Plastic surgery elective report (Supervisor: Mr. Philip Gilbert). Queen Victoria Hospital, East Grinstead, England, 1-20.
[9] Forest, L., Demongeot, J., Michon, F., Cadau, S. and Dhouailly, D. (2006) What is the biological basis of pat- tern formation of skin lesions? Experimental Dermatology, 15, 547-564.
[10] Bush, J., Ferguson, M.W., Mason, T. and McGrouther, G. (2007) The dynamic rotation of Langer’s lines on facial expression. Journal of Plastic, Reconstructive & Aesthetic Surgery, 60, 393-399. doi:10.1016/j.bjps.2006.06.008
[11] Scientific Panel on Biological Hazards of the European Food Safety Authority (EFSA) (2006) Quantitative assessment of the human BSE risk posed by gelatine with respect to residual BSE risk.
[12] US Food and Drug Administration (1997) The sourcing and processing of gelatin to reduce the potential risk posed by bovine spongiform encephalopathy (BSE) in FDA-regulated products for human use.
[13] Avita Medical Limited (Australia) (2010) Using RecellTM kit to treat flame burn in combination with wide mesh graft. www.Avitamedical.com

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.