Clear cell carcinoma of salivary gland type presenting as an endotracheal polypoid tumor

Kazuhiro Tabata, Michiyo Higashi, Shinichi Kitajima, Ikumi Kitazono, Tsubasa Hiraki, Tsunayuki Otsuka, Masaya Aoki, Kazuhiro Wakita, Hirofumi Nakayama, Suguru Yonezawa, Junya Fukuoka

Department of General Thoracic Surgery, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.
Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Department of Pathology, Kagoshima University Hospital, Kagoshima, Japan.
Department of Pathology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Laboratory of Pathology, Nagasaki University Hospital, Nagasaki, Japan;.

DOI: 10.4236/crcm.2013.22043                

Abstract

A 66-year-old woman presented with a 2-year history of asthma has progression of dyspnea within a week, and a computed tomography (CT) revealed an endotracheal tumor at level of aortic arch. The resected tumor, measured by 18 × 12 × 10 mm, has histologically malignant features including frank invasion with desmoplastic stroma and foci of necrosis. Presence of glycogen and mucin was confirmed by periodic acid-Schiff (PAS) and diastase PAS staining. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin (CK) 7 and AE1/3, focally positive for CK5/6 and CK14, but negative for CK20. Thyroid transcription factor-1 (TTF-1), Napsin A, and SP-A, indicating lung parenchymal origin were all negative. Other muscular markers, neuroendocrine markers, renal cell carcinoma markers, and markers related to perivascular epithelioid cell tumors were all negative. Postoperative systemic examination suggests no primary tumor outside the lung. The follow up was excellent being recurrence free for 14 months in spite of the positive surgical margin by the tumor cells. This is a first report  of rare neoplasm, clear cell carcinoma of salivary gland type, presenting as an endotracheal mass.

Keywords

Clear Cell Carcinoma; Salivary Gland; Lung Primary; Histological Feature

Conflicts of Interest

The authors declare no conflicts of interest.

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