Recurrent ameloblastoma of the mandible: Surgical seeding or metastasis of malignant ameloblastoma?

Christina Klee, Sven Lindskog, Jan-M. Hirsch, Andreas Thor

Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.
Department of Surgical Sciences, Oral & Maxillofacial Surgery, Uppsala University, Uppsala, Sweden;.

DOI: 10.4236/crcm.2013.22042                

Abstract

The controversy of surgical seeding or metastasis of a recurrent ameloblastoma is discussed in this paper, where we present a case with a history of 28 years since primary diagnosis including several tumor removals and reconstructive events. 23 years after primary diagnosis, we removed a metastasis from the neck with similar histological features as the primary tumor and the following recurrences of the mandible. We argue that the removed tumor in the neck most possibly has its origin in surgical seeding of cells during earlier resection and reconstruction and not by common ways of metastasis. The seeding of tumor cells during tumor surgery and metastasis rate of malignant ameloblastoma is discussed and the literature in this area is reviewed in the paper.

Keywords

Ameloblastoma; Surgical Seeding; Metastasis

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Waldron, C. (2002) Odontogenic cysts and tumors. In: Neville, B.W., Damm, D.D., Allen, C.M. and Bouquot, J.E., Eds, Oral and maxillofacial pathology, WB Saunders, Philadelphia, 589-704.
[2]	Walke, V.A., Munshi, M.M., Raut, W.K. and Sudhakar, K.B. (2008) Cytological diagnosis of acanthomatous ameloblastoma. Journal of cytology, 25, 62.
[3]	Campbell, D., Jeffrey, R.R., Wallis, F., Hulks, G. and Kerr, K.M. (2003) Metastatic pulmonary ameloblastoma. An unusual case. British Journal of Oral and Maxillofacial Surgery, 41, 194-196. doi:10.1016/S0266-4356(03)00046-9
[4]	Clay, R.P., Weiland, L.H. and Jackson, I.T. (1989) Ameloblastoma metastatic to the lung. Annals of Plastic Surgery, 22, 160-162. doi:10.1097/00000637-198902000-00013
[5]	Black, C.C., Addante, R.R. and Mohila, C.A. (2010) Intraosseous ameloblastoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Endodontology, 110, 585-592. doi:10.1016/j.tripleo.2010.02.040
[6]	Ferretti, C., Polakow, R. and Coleman, H. (2000) Recurrent ameloblastoma: Report of 2 cases. Journal of Oral and Maxillofacial Surgery, 58, 800-804. doi:10.1053/joms.2000.7271
[7]	Verneuil, A., Sapp, P., Huang, C. and Abemayor, E. (2002) Malignant ameloblastoma: Classification, diagnostic, and therapeutic challenges. American Journal of Otolaryngology, 23, 44-48. doi:10.1053/ajot.2002.28769
[8]	Barnes, L., Eveson, J.W., Reichart, P. and Sidransky, D. (2005) World Health Organization classification of tumours pathology and genetics of head and neck tumours, Odontogenic tumours. IARC Press, Lyon, 283-328.
[9]	Berger, A.J., Son, J. and Desai, N.K. (2012) Malignant ameloblastoma: Concurrent presentation of primary and distant disease and review of the literature. Journal of Oral and Maxillofacial Surgery, 10, 2316-2326. doi:10.1016/j.joms.2011.11.004
[10]	Hayakawa, K., Hayashi, E., Aoyagi, T., Hata, M., Kuramoto, C., Tonogi, M., Yamane, G.Y. and Tanaka, Y. (2004) Metastatic malignant ameloblastoma of the kidneys. International Journal of Urology, 11, 424-426. doi:10.1111/j.1442-2042.2004.00822.x
[11]	Van Dam, S.D., Unni, K.K. and Keller, E.E. (2010) Metastasizing (malignant) ameloblastoma: Review of a unique histopathologic entity and report of Mayo Clinic experience. Journal of Oral and Maxillofacial Surgery, 68, 2962-2974. doi:10.1016/j.joms.2010.05.084
[12]	Ciment, L.M. and Ciment, A.J. (2002) Malignant ameloblastoma metastatic to the lungs 29 years after primary resection: A case report. Chest, 121, 1359-1361. doi:10.1378/chest.121.4.1359
[13]	Mosqueda Taylor, A., Meneses Garcia, A., Ruiz Godoy Rivera, L.M., Suarez Roa Mde, L. and Luna Ortiz, K. (2003) Malignant odontogenic tumors. A retrospective and collaborative study of seven cases. Medicina Oral, 8, 110-121.
[14]	Kuramoto, C., Morisaki, S., Tonogi, M., Yamane, G. and Tanaka, Y. (2003) A case of malignant ameloblastoma that metastasized throughout the body. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Endodontology, 95, 429.
[15]	Henderson, J.M., Sonnet, J.R., Schlesinger, C. and Ord, R.A. (1999) Pulmonary metastasis of ameloblastoma: Case report and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Endodontology, 88, 170-176. doi:10.1016/S1079-2104(99)70113-7
[16]	Zwahlen, R.A., Vogt, P., Fischer, F.S. and Gratz, K.W. (2003) Case report: Myocardial metastasis of a maxillary malignant ameloblastoma. Journal of Oral and Maxillofacial Surgery, 61, 731-734. doi:10.1053/joms.2003.50146
[17]	Laughlin, E.H. (1989) Metastasizing ameloblastoma. Cancer, 64, 776-780. doi:10.1002/1097-0142(19890801)64:3<776::AID-CNCR2820640335>3.0.CO;2-8
[18]	Dissanayake, R.K., Jayasooriya, P.R., Siriwardena, D.J. and Tilakaratne, W.M. (2011) Review of metastasizing (malignant) ameloblastoma (METAM): Pattern of metastasis and treatment. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Endodontology, 111, 734-741. doi:10.1016/j.tripleo.2010.12.018
[19]	Vorzimer, J. and Perla, D. (1932) An instance of adamantinoma of the jaw with metastases to the right lung. American Journal of Pathology, 8, 445-454.
[20]	Kunze, E., Donath, K., Luhr, H.G., Engelhardt, W. and De Vivie, R. (1985) Biology of metastasizing ameloblastoma. Pathol Research and Practice, 180, 526-535. doi:10.1016/S0344-0338(85)80017-0
[21]	Newman, L., Howells, G.L., Coghlan, K.M., DiBiase, A. and Williams, D.M. (1995) Malignant ameloblastoma revisited. British Journal of Oral and Maxillofacial Surgery, 33, 47-50. doi:10.1016/0266-4356(95)90087-X
[22]	Zwahlen, R.A. and Gratz, K.W. (2002) Maxillary ameloblastomas: A review of the literature and of a 15-year database. Journal of Craniomaxillofacial Surgery, 30, 273-279.