A New Strategy for the Preparation of N-Aminopiperidine Using Hydroxylamine-O-Sulfonic Acid: Synthesis, Kinetic Modelling, Phase Equilibria, Extraction and Processes

E. Labarthe, A. J. Bougrine, Véronique Pasquet, H. Delalu

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Laboratoire Hydrazines et Composés Energétiques Polyazotés, UMR CNRS-CNES-SME-Groupe Safran, Université Claude Bernard Lyon 1, Villeurbanne, France.

DOI: 10.4236/aces.2013.32019                

Abstract

A new strategy for the synthesis of N-aminopiperidine (NAPP) was developed using hydroxylamine-O-sulfonic acid (HOSA). A systematic study of NAPP formation and degradation reactions was carried out in diluted medium, in order to identify products and to establish a kinetic modelling. Principal parameters have been defined, in particular, that obtaining high yields (>90%) requires non stoichiometric conditions. The extraction and purification processes were also studied. NAPP isolation and piperidine recycling were optimized after the establishment of the various solid-liquid-liquid and liquid-vapour implied phase diagrams. At least, a calorimetric study of solvatation and reaction enthalpies was undertaken in order to estimate reactor heating temperature in the case of anhydrous synthesis. The combination of our kinetic, thermodynamic and calorimetric data allows the establishment of two process schemes: one using pure piperidine, the other, a 66 w% titrating azeotropic solution in piperidine.

Keywords

Natural Asset; Financial Value; Neural Network

Conflicts of Interest

The authors declare no conflicts of interest.

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