Oral manifestations of acute promyelocytic leukemia: A case report

Daisuke Saito Daisuke Saito, Tadaharu Kobayashi, Yohei Oda, Kanae Niimi, Hiroyuki Kano, Chikara Saito

Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

DOI: 10.4236/ojst.2013.31005                

Abstract

Acute leukemia is often associated with oral manifestations. We report an acute promyelocytic leukemia (APL) case with oral manifestations leading to the diagnosis. A 21-year-old female visited our hospital with complaints of gingival bleeding and swelling of the left lower wisdom tooth. The patient’s complete blood count revealed a marked increase in white blood cells and a decrease in red blood cells and an abnormal leukocyte differential, and APL was diagnosed on the basis of bone marrow samples in the internal medicine department. The patient was treated with all-trans-retinoic acid combined with chemotherapy and has maintained clinical and molecular complete remission at 12 months of follow-up. Dental professionals should be aware of clinical manifestations and complications associated with these malign-nant neoplastic diseases to aid in diagnosis and subsequent treatment and management.

Keywords

Acute Promyelocytic Leukemia; OralManifestations; Oral Care

Conflicts of Interest

The authors declare no conflicts of interest.

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