Interferon-induced progression of autoimmune thyroiditis with enlarged thyroid glands in gynecological patient: A case report and literature review

Ospan Mynbaev, Marina Eliseeva, Artem Chernov, Ioannis Kosmas, Andrea Tinelli, Victor Radzinsky, Victor Tsarev

Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Department of Obstetrics and Gynecology, Vito Fazzi Hospital, Lecce, Italy.
Moscow State University of Medicine & Dentistry Named after A. I. Evdokimov, Moscow, Russia.
National Medical Academy of Post-Graduate Education Named after P. L. Shupik, Ministry of Health of Ukraine, Kyiv, Ukraine.
Peoples’ Friendship University of Russia, Moscow, Russia.
The Institute of Reproductive Technologies AltraVita, Moscow, Russia.
Xatzikosta General Hospital, Ioannina, Greece.

DOI: 10.4236/ojog.2013.32048                

Abstract

A case report presents a progression of autoimmune thyroiditis with an abnormal enlargement of the thyroid glands and increased thyreotropin hormone concentration-associated with interferon treatment in human papillomavirus infected patient with the autoimmune thyroiditis and a daily L-thyroxin hormone replacement therapy background. Observation was supplemented with a brief review of literature and discussion. On the basis of this observation and a brief review of literature authors suggested that the potential adverse effects of interferon therapy are overbalanced than its benefits for gynecological patients, therefore any interferon treatment should be recommended with strict indications as well as after screening of conditions and functions of thyroid glands and other interferon target organs to avoid interferon treatment side effects. Practitioners especially gynecologists should inform their patients about pleiotropic interferon effects and its high frequent and wide range side effects before to start such kind of treatment.

Keywords

Autoimmune Thyroiditis; Human Papillomavirus; Interferon; Thyroid Glands

Conflicts of Interest

The authors declare no conflicts of interest.

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