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Metal ion–binding properties of the L-aspartic acid and tartaric acid, a coparative investigation. How can be increased the dosage of mineral absorption in the body

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DOI: 10.4236/abb.2010.14047    6,366 Downloads   11,513 Views   Citations

ABSTRACT

A comparative research has been developed for acidity and stability constants of M(TTA)1 and M(Asp)2 complexes which have been determined by potentiometric pH titration. Depending on metal ion–binding properties, vital differences in building complex were observed. The present study shows that in M(TTA) complexes, metal ions are coordinated to the carboxyl groups, but in M(Asp) some metal ions are able to build macrochelate over amine group. Hence, the following intermolecular and as a result independent concentration equilibrium between an open–isomer M(Asp)op and a closed–isomer M(Asp)cl, has to be considered cl op. The amounts are reported. The results mentioned above demonstrate that for some M(Asp) complexes the stability constants is also largely determined by the affinity of metal ions for amine group. This leads to a kind of selectivity of metal ions and transfer them via building complexes with the aspartate. The result of this effect is a higher dosage-absorption of minerals in body. Based on the sort of metal ions, the drug-therapy can be different. For heavy metal ions this building complex helps the absorption and filtration of the blood plasma, and consequently the excursion of heavy metal ions takes place. This is an important method in microdialysis. Other metal ions such as the complexes can be considered as mineral carriers. These complexes in certain conditions (PH–range) can release the minerals in body.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Sajadi, S. (2010) Metal ion–binding properties of the L-aspartic acid and tartaric acid, a coparative investigation. How can be increased the dosage of mineral absorption in the body. Advances in Bioscience and Biotechnology, 1, 354-360. doi: 10.4236/abb.2010.14047.

References

[1] IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. Nomenclature and Symbolism for Amino Acids and Peptides, Recommendations on Organic & Biochemical Nomenclature, Symbols & Terminology etc. Retrieved on 2007-05-17.
[2] Nelson, D.L. and Cox, M.M. (2000) Lehninger, principles of biochemistry. 3rd Edition, Worth Publishing, New York.
[3] L. Stryer, (1995) Biochemistry.4th Edition, W. H. Freeman and Company, New York.
[4] Chen, P.E., Geballe, M.T., Stansfeld, P.J., Johnston, A.R., Yuan, H.J., Jacob, A.L., Snyder, J.P., Traynelis, S.F. and Wyllie, D.J.A. (2005) Structural features of the glutamate binding site in recombinant NR1/NR2A N-Methyl-D- lartate receptors determined by site-directed mutagenesis and molecular modeling. Molecular Pharmacology, 67, 1470-1484.
[5] Dunn, M.S. and Smart, B.W. (1963) DL-Lartic acid. Organic Syntheses, 4, 55.
[6] Martel, A.E. (2006) Critical stability constants of metal complexes 26.
[7] Ritchie, S.M.C., Bachas, L.G., Olin, T., Sikdar, S.K. and Bhattacharyya, D. (1999) Langmuir. 15(19), 6346-6357.
[8] Xiao, S., Textor, M., Spencer, N.D. and Sigrist, H. (1998) Langmuir. 14, 5507.
[9] Konishi, Y., Shimaoka, J. and Asai, S. (1998) Reactive and Functional Polymers. 36, 197.
[10] Reichert, J. and Binner, J.G.P. (1996) Journal of Matierals Science, 31, 1231.
[11] Bonn, G., Reiffenstuhl, S. and Jandik, P.J. (1990) Chromatogr. 499, 669.
[12] Bhattacharyya, D.; Hestekin, J. A.; Brushaber, P.; Cullen, L.; Bachas, L. G.; Sikdar, S. K. J. Membr. Sci. 1998, 141, 121.
[13] Dikabo Mogopodi and Nelson Torto, Analytica Chimica Acta Volume 482, Issue 1, (2003), Pages 91-97.
[14] S. A. A. Sajadi, A.A. Alamolhoda, A. Nazari Alavi, Scientica Iranica, (2009) in press.
[15] S. Ali A. Sajadi, Bin Song, Helmut Sigel, Inorg. Chim. Acta 283 (1998) 193-201.
[16] S. Ali A. Sajadi, Bin Song, Fridrich Gregan, Helmut Sigel, Inorg. Chem. 38(3) (1999) 439-448.
[17] S.Ali A. Sajadi, Bin Song, Fridrich Gregan,and Helmut Sigel, Bull. Chem. Soc. Ethiop. 11(2) (1997) 121-130.
[18] S. Ali A. Sajadi, Matthias Bastian, Helmut Sigel, J. Inorg. Biochem. 59(2,3) (1995) 139.
[19] Handbook of Chem. & Physics 55 (1975) D-129.
[20] J. L. Miranda, J. Felcman, Polyhedron, 22 (2003) 225- 233.
[21] J. Felcman, J.L. Miranda, J. Braz. Chem. Soc. 8 (1997) 575.
[22] D. Voet, Biochemistry, John Wiley, (1997) 560.
[23] IUPAC Stability Conatants Database, Release 3, version 3.02, coplied by L.D. Pettit, H.K. J. Powel, Academic Software Timble, UK, (1998).
[24] H. Irving, R.J.P. Williams, J. Chem. Soc., (1953) 3192-3210.
[25] T. Tsukihara, Y. Katsube, Bull. Chem.Soc. Jpn. 1972, 45, 1367.
[26] N. Torto, J. Mwatseteza and G. Sawula. Anal. Chim. Acta 456 (2001), p. 253.
[27] E.M. Janle, M. Cregor and J. Sojka. Curr. Separat. 19 (2001), p. 80.
[28] D.D. Allen and R. A Yokel. J. Neurochem. 58 (1992), p. 903.
[29] www.niddk.nih.gov.
[30] M. Guo, H. Zou, H. Wang, L. Kong and J. Ni. Anal. Chim. Acta 443 (2001), p. 91.
[31] G. Kiseleva, P.A. Kebets and P.N. Nesterenko. Analyst 126 (2002), p. 2119.
[32] S.M.C. Ritchie, L.G. Bachas, T. Olin, S.K. Sikdar and D. Bhattacharyya. Langmuir 15 (1999), p. 6346.
[33] J.J. Gooding, D.B. Hibbert and W. Yang. Sensors 1 (2001), p. 75.
[34] A. Battistoni, F. Pacello, A.P. Mazzetti, C. Capo, J.S. Kroll, P.R. Langford, A. Sansone, G. Donnarumma, P. Valenti and G. Rotilio. J.B.C. 276 (2001), p. 30315.
[35] S A Jablonski and C D Morrow, J Virol. 1995 March; 69(3): 1532–1539.
[36] Romualda Bregier-Jarzebowska, Anna Gasowska, and Lechos?aw Lomozik, Bioinorganic Chemistry and Applications, Volume 2008 (2008), Article ID 253971.
[37] The technology of achieving this structure is patented and was jointly developed by Elixir Industry, Las Vegas, NV 89104-7900, USA, and the Chinese National Institute of Pharmaceutical Industry.

  
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