The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes

Fulvia Gloria-Bottini, Krzysztof Safranow, Maria Banci, Agnieszka Binczak-Kuleta, Patrizia Saccucci, Andrzej Ciechanowicz, Andrea Magrini, Zdzislawa Kornacewicz-Jach, Egidio Bottini, Dariusz Chlubek

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
Department of Cardiology, Pomeranian Medical University, Szczecin, Poland.
Department of Cardiology, Valmontone Hospital, Valmontone, Italy.
Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland.

DOI: 10.4236/health.2013.52022                

Abstract

An association between ADA₁ and Coronary Artery Disease (CAD) has been observed in Polish and in Italian populations but in Italian population the association was present in males only. In order to enlighten these differences we have carried out a collaborative study in the two populations. In Italy 215 subjects admitted to the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without CAD and 398 healthy new-borns were studied. In Poland 173 subjects with CAD and 200 healthy newborns were studied. Written informed consent was obtained from all subjects or from their mothers to participate to the study that was approved by the I.R.B. ADA₁ polymorphism was determined by DNA analysis. Three way contingency table analysis was performed by a log linear model. The association between CAD and ADA₁ is present in non diabetic male subjects only: OR = 0.195, p = 0.007 in the Italian population and OR = 0.163, p = 0.004 in the Polish population. The data suggest a significant role of immunological mechanisms in the pathogenesis of CAD without diabetes. Gender differences in immune diseases could explain the lack of association in females.

Keywords

ADA; CAD; Gender; Diabetes

Conflicts of Interest

The authors declare no conflicts of interest.

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