Inorganic Molecularly Imprinted Polymer by Sol-Gel Process for Recognition of Caffeine

Min Jae Shin, Young Jae Shin, Jae Sup Shin

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Department of Chemistry, Chungbuk National University, Cheongju, Korea.
Macromolecular Science and Engineering, University of Michigan, Ann Arbor, USA.

DOI: 10.4236/ojopm.2013.31001                

Abstract

A molecularly imprinted polymer (MIP) was formed using an inorganic polymer by a sol-gel process. The monomers which were used to synthesize the inorganic polymer were tetraethoxysilane (TEOS), triethoxymethylsilane (MTES), and triethoxyphenylsilane (PTES). Caffeine was chosen as a template for the molecular imprinting, and theophylline was chosen as the analogous counterpart compound. The discriminating ability of the synthesized MIP to these two-compounds was estimated in this study. The MIP showed the highest discriminating ability when the ratio of TEOS:MTES: PTES in the synthesis of the inorganic polymer was 1:1:3, the reaction temperature was 50?C, and the pH of the reaction system was ~6.5.

Keywords

Molecularly Imprinted Polymer; Sol-Gel Process; Caffeine; Theophylline

Conflicts of Interest

The authors declare no conflicts of interest.

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