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Partial Reflection of Hyaluronan Molecules Inside the Taylor-cone During Electrospray

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DOI: 10.4236/eng.2012.410B022    5,938 Downloads   7,038 Views   Citations
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ABSTRACT

Electrospray (ES) is of great interest in research for its finely controlled delivery of molecules. This study investigated mechanisms involved in the electrospray of biological macromolecules which may cause spraying instabilities. Hyaluronan (HA) has been studied for its biological significance. A mixture of ethylene glycol and deionized water with volume ratio of 1:1 is used to dissolve HA molecules. HA solutions with different concentrations and molecular sizes are investigated. Experimental results demonstrate that the molecular size and solution concentration of macro-molecules are critical factors affecting the spraying process. A concentration reduction of HA molecules happened during the ES process, and a hypothesis on partial reflection of HA molecules inside the Taylor-cone is presented in the study.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Z. Tan, "Partial Reflection of Hyaluronan Molecules Inside the Taylor-cone During Electrospray," Engineering, Vol. 4 No. 10B, 2012, pp. 84-87. doi: 10.4236/eng.2012.410B022.

References

[1] Oleg, V.S., “Tools of Nanotechnology: Electrospray”. Current Nanoscience, 2005, (1), 25-33.
[2] Park, J.-U., Lee, S., Unarunotai, S., Sun, Y., Dunham, S., Song, T., Ferreira, P., Alleyene, A., Paik, U., & Rogers, J. “Nanoscale, Electrified Liquid Jets for High-Resolution Printing of Charge”. Nano Letters, 2010, (10), 584-591.
[3] Fernández de la Mora, J. “The Fluid Dynamics of Taylor Cones”. Annual Review of Fluid Mechanics, 2007, (39), 217-243.
[4] Fernández de la Mora, J., & Loscertales, I.G. “The current emitted by highly conducting Taylor cones”. Journal of Fluid Mechanics, 1994, (260), 155-184.
[5] Wang, K., & et al. “Fully voltage-controlled electrohydrodynamic jet printing of conductive silver tracks with a sub-100μm linewidth”. Journal of applied physics, 2009, (106), 024907.
[6] Yogi, O., Kawakami, T., & Mizuno, A. “Properties of droplet formation made by cone jet using a novel capillary with an external electrode”. Journal of Electrostatics, 2006, (64), 634-638.
[7] Delamarche, E., Juncker, D., & Schmid, H. “Microfluidics for processing surfaces and miniaturizing biological assays”. Advanced Materials, 2005, (17), 2911-2933.
[8] He, M., Edgar, J.S., Jeffries, G.D.M., Lorenz, R.M., Shelby, J.P., & Chiu, D.T. “Selective Encapsulation of Single Cells and Subcellular Organelles into Picoliter- and Femtoliter-Volume Droplets”. American Chemical Society Journals, 2005, (77), 1539-1544.
[9] Rietveld, I.B., Kobayashi, K., Yamada, H., & Matsushigea, K. “Morphology control of poly(vinylidene fluoride) thin film made with electrospray”. Journal of Colloid and Interface Science, 2006, (298), 639-651.
[10] Um, I.C., Fang, D., Hsiao, B.S., Okamoto, A., & Chu, B. “Electro-Spinning and Electro-Blowing of Hyaluronic Acid”. Biomacromolecules, 2004, (5), 1428-1436.
[11] Stern, R. “Hyaluronan catabolism: a new metabolic pathway”, European Journal of Cell Biology, 2004, (83), 317-325.
[12] Ji, Y., Ghosh, K., Shu, X.Z., Li, B., Sokolov, J.C., Prestwich, G.D., Clark, R.A.F., & Rafailovich, M.H. “Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds”. Biomaterials, 2006, (27), 3782-3792.
[13] Barrero, A., Ganán-Calvo, A.M., Dávila, J., Palacio, A., & Gómez-González, E. “Low and high Reynolds number flows inside Taylor cones”. Physical Review E, 1998, (58), 7309.?
[14] Hayati, I., Bailey, A.I., & Tadros, T.F. “Mechanism of stable jet formation in electrohydrodynamic atomization”. Nature, 1986, (319), 41-43.
[15] Hayati, I., Bailey, A.I., & Tadros, T.F. “Investigations into the mechanisms of electrohydrodynamic spraying of liquids : I. Effect of electric field and the environment on pendant drops and factors affecting the formation of stable jets and atomization”. Journal of Colloid and Interface Science, 1987, (117), 205-221.
[16] Sheldon, A.M. “Visualization of fluid motions in Taylor Cones using dye tracer”. Queen Mary, University of London, London. 2009
[17] Barrero, A., Ganan-Calvo, A.M., & Fernandez-Feria, R. “he role of liquid viscosity and electrical conductivity on the motions inside Taylor cones in E.H.D. spraying of liquids”. Journal of Aerosol Science, 1996, (27), S175-S176.
[18] Coleman, P.J., Scott, D., Mason, R.M., & Levick, J.R. “Role of hyaluronan chain length in buffering interstitial flow across synovium in rabbits”. Journal of Physiology, 2000, (526), 425-434.

  
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