Clinicolopathological, Cytogenetic, and Radiographical Analysis of Waldenstrom Macroglobulinemia in Japan: Unique Disease Manifestation

Naohiro Sekiguch, Naoki Takezako, Miyuki Wagatsuma, Chen A. Kunihiro, Akihisa Nagata, Ichiro Fukuda, Satoshi Noto, Ikuo Saito, Kazuaki Yamada, Akiyoshi Miwa

Division of Hematology, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Division of Pathology, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Division of Pathology, National Hospital Organization Sagamihara Hospital, Sagamihara, Japan.
Division of Radiology, National Hospital Organization Disaster Medical Center, Tokyo, Japan;.
Hematology Division, National Center for Global Health and Medicine, Tokyo, Japan..

DOI: 10.4236/jct.2012.36134                

Abstract

Waldenstr?m macroglobulinemia (WM) is a rare lymphoid malignancy. Many studies, including clinicopathological, cytogenetic, gene expression profile, and therapy studies have been reported from the US and Europe, although only a few reports are available from East Asia, including Japan. To further clarify the clinicopathological, radiological, and cytogenetic features of WM in Japan, we performed a retrospective analysis of WM in our institute between March 2007 and January 2012. Clinical data, laboratory data, the results of flow cytometric analysis (FCM), and chromosomal abnormalities were analyzed, and a radiological review was performed. The treatment regimen, response, and survival were also estimated. Six patients were enrolled in this study. The median age was 71 years. All patients were symptomatic, 3 had hyperviscosity syndrome, 1 had bone lesions, and 1 had an extra-medullary mass. FCM data showed that all patients were positive for CD38, while 2 were positive for CD56. Four had chromosomal abnormalities including some abnormalities also reported in myeloma. On radiological review, four showed diffuse invasion of the retro-peritoneum. Five patients received treatment, 4 of which achieved a response. At a median follow-up of 527 days, 4 were alive and 2 died because of disease progression. The present study revealed that WM in Japan might be heterogeneous and have a unique disease manifestation. Invasion sites other than bone marrow were very common, and the results of clinical, FCM, and cytogenetic studies revealed that WM in Japanese cases might have manifestations of both myeloma and B-cell lymphoma.

Keywords

Lymphoplasmacytic Lymphoma; Woldenström Macroglobulinemia; Lymphadenopathy; Flow Cytometry; Pathology; Cytogenetics; Japan

Conflicts of Interest

The authors declare no conflicts of interest.

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