Prevalence and Correlates of Dyslipidemia among Adults in Saudi Arabia: Results from a National Survey

Abstract

Data were collected and analyzed from a cross-sectional study using the World Health Organization’s STEPwise approach, to estimate the prevalence of various types of dyslipidemia and determine their associated factors among adults in Kingdom of Saudi Arabia. The study population included 4490 Saudi adults aged 15 years and older who were selected by a stratified, multistage, cluster random sampling technique. Lipid profile was determined by spectrophotometrically by biochemical methods, high total cholesterol (TC) was defined as TC of 5.2 mmol/L or more, hypertriglyceridemia as serum triglycerides level 1.7 mmol/L or more and. low high-density lipoprotein cholesterol (HDL-C) as serum HDL-C 0.9 mmol/L or less, LDL-C 3.35 mmol/L or more and TC/HDL ratio 5 or more. Of the 4490 subjects (94.4 % of total sample) included in the final analysis, 51% were females, 23% of study subjects were less than 25years and 11% were 55 or more years of age. The overall prevalence of dyslipidemia ranged from about 20% to 40%. The highest prevalence was for triglycerides where about 44% of all subjects were affected. About a fifth of the subjects had high level of total cholesterol. Males had significantly higher prevalence of all types of dyslipidemia than female except LDL-C and TC. Higher dyslipidemia prevalence of total cholesterol and triglycerides were significantly found in older subjects, illiterates and housekeepers. Lower prevalence rates for HDL-C was significantly observed in retired and youngest subjects. There were significant regional variations and significantly higher prevalence of dyslipidemia among hypertensives, diabetics, obese/overweight, smokers and physically inactive subjects. There were no significant differences according to income or fruits and vegetable consumption. Logistic regression analysis revealed that obesity/overweight, gender, age, diabetes were the most important significant predictors of dyslipidemia. The findings of this study suggest that the prevalence of dyslipidemia is high in Saudi Arabia. Multisectorial intervention strategies are needed targeting the predictors and significant risk factors identified.

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A. F. Al-Kaabba, N. A. Al-Hamdan, A. El Tahir, A. M. Abdalla, A. A. Saeed and M. A. Hamza, "Prevalence and Correlates of Dyslipidemia among Adults in Saudi Arabia: Results from a National Survey," Open Journal of Endocrine and Metabolic Diseases, Vol. 2 No. 4, 2012, pp. 89-97. doi: 10.4236/ojemd.2012.24014.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] World Health Organization, “Quantifying Selected Major Risks to Health,” World Health Organization, Geneva, 2002.
[2] D. Smith, “Epidemiology of Dyslipidemia and Economic Burden on the Healthcare System,” American Journal of Managed Care, Vol. 13, No. S3, 2007, pp. S68-S71.
[3] J. Stamler, M. L. Daviglus, D. B. Garside, A. R. Dyer, P. Greenland, et al., “Relationship of Baseline Serum Cholesterol Levels in 3 Large Cohorts of Younger Men to Long-Term Coronary, Cardiovascular, and All-Cause Mortality and to Longevity,” The Journal of the American Medical Association, Vol. 284, No. 3, 2000, pp. 311-318. doi:10.1001/jama.284.3.311
[4] WHO, “Country Cooperation Strategy for WHO and Saudi Arabia 2006-2011,” 2012. http://www.who.int/countryfocus/cooperation_strategy/ccs_sau_en.pdf
[5] M. M. Al-Nozha, M. R. Arafah, M. A Al-Maatouq, M. Z. Khalil, N. B. Khan, K. Al-Marzouki, Y. Y. Al-Mazrou, M. Abdullah, A. Al-Khadra, S. S. Al-Harthi, M. S. Al-Shahid, A. Al-Mobeireek and M. S. Nouh, “Hyperlipidemia in Saudi Arabia Saudi,” Medical Journal, Vol. 29, No. 2, 2008, pp. 282-287.
[6] D. O. Ogbeide, A. Karim, I. M. Al-Khalifa and S. Siddique, “Population Based Study of Serum Lipid Levels in Al-Kharj Health Center, Saudi Arabia,” Saudi Medical Journal, Vol. 25, No. 12, 2004, pp. 1855-1857.
[7] S. N. Al-Shehri, Z. A. Saleh, M. M. Salama and Y. M. Hassan, “Prevalence of Hyperlipidemia among Saudi School Children in Riyadh,” Annals of Saudi Medicine, Vol. 24, No. 1, 2004, pp. 6-8.
[8] B. A. Abalkhail, S. Shawky, T. M. Ghabrah and W. A. Milaat, “Hypercholesterolemia and 5-Year Risk of Development of Coronary Heart Disease among University and School Workers in Jeddah, Saudi Arabia,” American Journal of Preventive Medicine, Vol. 31, No. 4, 2000, pp. 390-395. doi:10.1006/pmed.2000.0713
[9] R. Bonita, M. de Courten, T. Dwyer, K. Jamorzik and R. Winkelmann, “Surveillance of Risk Factors for NonCommunicable Diseases,” The WHO Stepwise Approach, WHO, 2001.
[10] WHO, EMRO, “STEPwise WHO,” 2005. http://www.who.int/chp/steps/2005_Saudi Ara bia_STEPS_Report_EN.pdf
[11] W. T. Friedewald, R. I. Levy and D. S. Frederickson, “Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, without Use of the Preparative Ultracentrifuge,” Journal of Clinical Chemistry, Vol. 18, No. 6, 1972, pp. 499-502.
[12] “Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III),” The Journal of the American Medical Association, Vol. 285, No. 19, 2001, pp. 2486-2497. doi:10.1001/jama.285.19.2486
[13] H. Saadi, S. G. Carruthers, N. Nagelkerke, et al., “Prevalence of Diabetes Mellitus and Its Complications in a population-Based Sample in Al-Ain, United Arab Emirates,” Diabetes Research and Clinical Practice, Vol. 78, No. 3, 2007, pp. 369-377. doi:10.1016/j.diabres.2007.04.008
[14] R. T. Jackson, Z. Al-Mousa, M. Al-Raqua, P. Prakash and A. N. Muhanna, “Multiple Coronary Risk Factors in Healthy Older Kuwaiti Males,” European Journal of Clinical Nutrition, Vol. 56, No. 8, 2002, pp. 709-714. doi:10.1038/sj.ejcn.1601379
[15] S. Al-Moosa, S. Allin, N. Jemiai, J. Al-Lawati and E. Mossialos, “Diabetes and Urbanization in the Omani Population: An Analysis of National Survey Data,” Population Health Metrics, Vol. 4, No. 5, 2006, p. 5. doi:10.1186/1478-7954-4-5
[16] A. Bener, M. Zirie, I. M. Janahi, O. A. Al-Hamaq and M. Musallam, “Prevalence of Diagnosed and Undiagnosed Diabetes Mellitus and Its Risk Factors in a Population Based Study of Qatar,” Diabetes Research and Clinical Practice, Vol. 84, No. 1, 2009, pp. 99-106. doi:10.1016/j.diabres.2009.02.003
[17] Y. S. Khader, A. Batieha, M. El-Khateeb, M. Al Omari and K. Ajlouni, “Prevalence of Dyslipidemia and Its Associated Factors among Jordanian Adults,” Journal of Clinical Lipidology, Vol. 4, No. 1, 2010, pp. 53-58. doi:10.1016/j.jacl.2009.12.004
[18] C. Pongchaiyakul, P. Hongsprabhas, V. Pisprasert and C. Pongchaiyakul, “Rural-Urban Difference in Lipid Levels and Prevalence of Dyslipidemia: A Population-Based Study in Khon Kaen Province, Thailand,” Journal of the Medical Association of Thailand, Vol. 89, No. 11, 2006, pp. 1835-1844.
[19] W. H. Zhao, J. Zhang, Y. Zhai, Y. You, Q. Q. Man, et al., “Blood Lipid Profile and Prevalence of Dyslipidemia in Chinese Adults,” Biomedical and Environmental Sciences, Vol. 20, No. 4, 2007, pp. 329-335.
[20] W. M. Kang, J. S. Zhang, X. X. Liu, M. S. Wang and M. L. Zhao, “Prevalence of Abnormity of Blood Lipid and Associated Factors in Health Examination Population in Beijing,” Chinese Medical Sciences Journal, Vol. 24, No. 3, 2009, pp. 142-146. doi:10.1016/S1001-9294(09)60078-X
[21] C. Erem, A. Hacihasanoglu, O. Deger, et al., “Prevalence of Dyslipidemia and Associated Risk Factors among Turkish Adults: Trabzon Lipid Study,” Endocrine, Vol. 34, No. 1-3, 2008, pp. 36-51. doi:10.1007/s12020-008-9100-z
[22] F. Azizi, M. Rahmani, A. Ghanbarian, H. Emami, P. Salehi, P. Mirmiran and N. Sarbazi, “Serum Lipid Levels in an Iranian Adults Population: Tehran Lipid and Glucose Study,” European Journal of Epidemiology, Vol. 18, No. 4, 2003, pp. 311-319. doi:10.1023/A:1023606524944
[23] R. W. Mahley, K. E. Palaoglu, Z. Atak, J. Dawson-Pepin, A. M. Langlois, V. Cheung, H. Onat, P. Fulks, L. L. Mahley, F. Vakar, S. Ozbayrakc?, O. Gokdemir and W. Winkler, “Turkish Heart Study: Lipids, Lipoproteins, and Apolipoproteins,” The Journal of Lipid Research, Vol. 36, No. 4, 1995, pp. 839-859.
[24] V. Grabauskas, I. Miseviciene, J. Klumbiene, J. Petkeviciene, Z. Milasauskiene, A. Plieskiene and L. Margeviciene, “Prevalence of Dyslipidemias among Lithuanian Rural Population (CINDI Program),” Medicina (Kaunas), Vol. 39, No. 12, 2003, pp. 1215-1222.
[25] E. Polychronopoulos, D. B. Panagiotakos and A. Polystipioti, “Diet, Lifestyle Factors and Hypercholesterolemia in Elderly Men and Women from Cyprus,” Lipids in Health and Disease, Vol. 4, No. 17, 2005, pp. 1-7. doi:10.1186/1476-511X-4-17
[26] L. J. de Souza, J. T. Souto Filho, T. F. de Souza, et al., “Prevalence of Dyslipidemia and Risk Factors in Campos dos Goytacazes, in the Brazilian State of Rio de Janeiro,” Arquivos Brasileiros de Cardiologia, Vol. 81, No. 3, 2003, pp. 249-264.
[27] R. Pradeepa, R. Deepa, S. S. Rani, G. Premalatha, R. Saroja and V. Mohan, “Socioeconomic Status and Dyslipidaemia in a South Indian Population: The Chennai Urban Population Study (CUPS 11),” National Medical Journal of India, Vol. 16, No. 2, 2003, pp. 73-78.
[28] S. Wang, L. Xu, J. B. Jonas, Q. S. You, Y. X. Wang, et al., “Prevalence and Associated Factors of Dyslipidemia in the Adult Chinese Population,” PLoS One, Vol. 6, No. 3, 2011, p. e17326. doi:10.1371/journal.pone.0017326
[29] R. W. Mahley, S. Can, S. Ozbayrakci, T. P. Bersot, S. Tanir, K. E. Palaoglu and G. M. Pepin, “Modulation of High-Density Lipoproteins in a Population in Istanbul, Turkey, with Low Levels of High-Density Lipoproteins,” American Journal of Cardiology, Vol. 96, No. 4, 2005, pp. 547-555. doi:10.1016/j.amjcard.2005.04.018
[30] J. Yarnell, S. Yu, E. McCrum, D. Arveiler, B. Hass, J. Dallongeville, M. Montaye, P. Amouyel, J. Ferrieres, J. B. Ruidavets, A. Evans, A. Bingham, P. Ducimetiere and PRIME Study Group, “Education, Socioeconomic and Lifestyle Factors, and Risk of Coronary Heart Disease: The Prime Study,” International Journal of Epidemiology, Vol. 34, No. 2, 2005, pp. 268-275. doi:10.1093/ije/dyh267
[31] Z. R. Guo, X. S. Hu, M. Wu, M. H. Zhou and Z. Y. Zhou, “A Prospective Study on the Association between Dyslipidemia and Hypertension,” Chinese Journal of Epidemiology, Vol. 30, No. 6, 2009, pp. 554-558.
[32] Z. H. Liu, X. B. Xue and Z. Zhi, “Prevalence of Dyslipidemia and Associated Factors among the Hypertensive Rural Chinese Population,” Archives of Medical Research, Vol. 38, No. 4, 2007, pp. 432-439.
[33] S. A. Grover, L. Coupal, H. Zowall, T. W. Weiss and C. M. Alexander, “Evaluating the Benefits of Treating Dyslipidemia: The Importance of Diabetes as a Risk Factor,” American Journal of Medicine, Vol. 115, No. 2, 2003, pp. 122-128. doi:10.1016/S0002-9343(03)00303-6
[34] S. J. Song, J. E. Lee, H. Y. Paik, M. S. Park and Y. J. Song, “Dietary Patterns Based on Carbohydrate Nutrition Are Associated with the Risk for Diabetes and Dyslipidemia,” Nutritional Research and Practice, Vol. 6, No. 4, 2012, pp. 349-356. doi:10.4162/nrp.2012.6.4.349

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