In Vivo Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-A^y Mice

Sayaka Iwasaki, Made Airanthi Kusum Widjaja-Adhi, Ai Koide, Takerou Kaga, Seita Nakano, Fumiaki Beppu, Masashi Hosokawa, Kazuo Miyashita

Laboratory of Bio-Functional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Japan.
Laboratory of Bio-Functional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Japan..

DOI: 10.4236/fns.2012.311194                

Abstract

Dietary intake of 0.1% fucoxanthin significantly reduced lipid hydroperoxide levels of liver and abdominal white adipose tissue (WAT) of obese/diabetes KK-A^y mice. The fucoxanthin supplementation also significantly reduced blood glucose level and hepatic lipid contents of the mice. Oxidative stress is known to be induced in hyperglycemia and high fat conditions. Therefore, in vivo antioxidant activity of fucoxanthin found in the present study could be attributed to its anti-diabetic effect and its decreasing effect on hepatic lipids. On the other hand, little effect of fucoxanthin on lipid hydroperoxide levels was found in normal ICR mice. Although the content of fucoxanthin metabolites in the abdominal WAT of KK-A^y mice was about 50 times higher that in the liver, there was little difference in its In Vivo antioxidant activity between in the liver and in the abdominal WAT. These results suggest that well-known ability of fucoxanthin to scavenge active oxygen species and/or free radicals would not be a main reason to explain its In Vivo antioxidant activity.

Keywords

Fucoxanthin; In Vivo Antioxidant Activity; Anti-Diabetic Effect; KK-A^y Mice

Conflicts of Interest

The authors declare no conflicts of interest.

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