Antenatal Sonographic Diagnosis of A Case of Alobar Holoprosencephaly: A Case Report

Rizwan Ahmad Khan, Manjari Thapa, Shagufta Wahab

Deptt. of Radiodiagnosis, JNMCH, Aligarh, India.
Deptt. of Radiodiagnosis, JNMCH, AMU,Aligarh, India.
Division of Pediatric Sugery, Deptt of Surgery, JNMCH, AMU,Aligarh.

DOI: 10.4236/ijcm.2012.35080                

Abstract

Holoprosencephaly is a rare congenital brain malformation resulting from failure of diverticulation and cleavage of primitive prosencephalon which occurs at 4 - 8^th week of gestation and is usually associated with multiple midline facial anomalies. Herein we report an antenatal case of such patient. Patient was evaluated and because of the magnitude of the problem induction was done which led to a still born baby.

Keywords

Holoprosencephaly; Alobar; Antenatal Detection; Developing Countries; Prognosis

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Epelman M, Daneman A, Blaser SI, Ortiz-Neira C, Konen O, Jarrin J, Navarro OM (2006) Differential diagnosis of intra-cranial cystic lesions at head US: Correlation with CT and MR Imaging. Radiographics 26:173-196.
[2]	Filly RA, Chinn DH, Callen PW (1984) Alobar Holoprosencephaly: Ultrasonographic Prenatal Diagnosis. Radiology 151: 455-9.
[3]	Manelfe C, Sevely A (1982) Neuroradiological study of holoprosencephalies. J Neuroradiol 9:15-45.
[4]	DeMyer W, Zeman W, Palmer C (1964). The face predicts the brain: diagnostic significance of median facial anomalies for holoprosencephaly (arhinencephaly). Pediatrics 34:256-63.
[5]	McGahan JP, Nyberg DA, Mack LA (1990) Sonography of facial features of alobar and semilobar holoprosencephaly. AJR 154: 143-8.
[6]	Mernagh JR, Mohide PT, Lappalainen RE, Fedoryshin JG (1999) US Assesment of the fetal head and neck: A state of the art pictorial review. Radiographics 19:S229-S241.
[7]	Fong KKW, Toi A, Salem S, Hornberger LK, Chitayat D, Keating SJ, McAuliffe F, Johnson JA (2004) Detection of fetal structural abnormalities with US during early pregnancy. Radiographics 24:157-74.
[8]	Nyberg DA, Mack LA, Bronstein A, Hirsch J, Pagon RA (1987) Holoprosencephaly: Prenatal Sonographic diagnosis. AJR 149:1051-8.
[9]	Lowe LH, Booth TN, Joglar JM, Rollins NK (2000) Midface Anomalies in children. Radiographics 20:907-22.
[10]	Cayea PD, Balcar I, Alberti O Jr., Jones TB (1984) Prenatal diagnosis of semilobar holoprosencephaly. AJR 142:401-2.