Considerations on Blood Platelets: A Neuron’s Mirror for Mood Disorders?

Abstract

This work aims to be a reflection concerning a remarkable similarity between platelet and neuron. Through a series of experimental tests which have affected the fatty acid composition of the membrane of platelets, it was possible to provide a contribution to the scientific literature, which had already reported strong similarities between platelet and neuron. The work performed could be of great interest to investigate, by studying the interactome of the platelet, the molecular behavior of the neuron.

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M. Cocchi, L. Tonello and F. Gabrielli, "Considerations on Blood Platelets: A Neuron’s Mirror for Mood Disorders?," Open Journal of Blood Diseases, Vol. 2 No. 2, 2012, pp. 22-29. doi: 10.4236/ojbd.2012.22005.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] C. A. Evers and L. Starr, “Biology: Concepts and Applications,” 6th Edition, Thomson, United States, 2006.
[2] P. J. Marangos, I. C. Campbell, D. E. Schmechel, D. L. Murphy and F. K. Goodwin, “Blood Platelets Contain a Neuron-Specific Enolase Subunit,” Journal of Neurochemistry, Vol. 34, No. 5, 1980, pp. 1254-1258. doi:10.1111/j.1471-4159.1980.tb09967.x
[3] B. Leonard, “Clinical Implications of Mechanisms of Action of Antidepressants,” Advances in Psychiatric Treatment, Vol. 6, 2000, pp. 178-186. doi:10.1192/apt.6.3.178
[4] J. Olesen, P. J. Goadsby, N. M. Ramadan, P. Tfelt-Hansen and K. M. A. Welch, “The Headaches,” 3rd Edition, Lippincott Williams & Wilkins, Philadelphia, 2006.
[5] S. Takahashi, “Reduction of Blood Platelet Serotonin Levels in Manic and Depressed Patients,” Folia Psychiatrica et Neurologica Japonica, Vol. 30, No. 4, 1976, pp. 476-486.
[6] S. M. Stahl, “The Human Platelet. A Diagnostic and Research Tool for the Study of Biogenic Amines in Psychiatric and Neurologic Disorders,” Archives of General Psychiatry, Vol. 34, No. 5, 1977, pp. 509-516. doi:10.1001/archpsyc.1977.01770170019001
[7] A. Pletscher and A. Laubscher, “Blood Platelets as Models for Neurons: Uses and Limitations,” Journal of Neural Transmission Supplementa, Vol. 16, 1980, pp. 7-16.
[8] M. Da Prada, A. M. Cesura, J. M. Launay and J. G. Richards, “Platelets as a Model for Neurones? Cellular and Molecular Life Sciences, Vol. 44, No. 2, 1988, pp. 115126. doi:10.1007/BF01952193
[9] H. L. Kim, O. Plaisant, M. Leboyer, C. Gay, L. Kamal, M. A. Devynck and P. Meyer, “Reduction of Platelet Serotonin in Major Depression (Endogenous Depression),” C R Seances Acad Sci III, Vol. 295, No. 10, 1982, pp. 619-622.
[10] D. L. Musselman, A. Tomer, A. K. Manatunga, B. T. Knight, M. R. Porter, S. Kasey, U. Marzec, L. A. Harker and C. B. Nemeroff, “Exaggerated Platelet Reactivity in Major Depression,” American Journal of Psychiatry, Vol. 153, No. 10, 1996, pp. 1313-1317.
[11] A. Camacho and J. E. Dimsdale, “Platelets and Psychiatry: Lessons Learned from Old and New Studies,” Psychosomatic Medicine, Vol. 62, No. 3, 2000, pp. 326-336.
[12] H. Plein and M. Berk, “The Platelet as a Peripheral Marker in Psychiatric Illness,” Human Psychopharmacology, Vol. 16, No. 3, 2001, pp. 229-236. doi:10.1002/hup.251
[13] C.L. Bowden, “Strategies to Reduce Misdiagnosis of Bipolar Depression,” Psychiatric Services, Vol. 52, No. 1, 2001, pp. 51-55. doi:10.1176/appi.ps.52.1.51
[14] H. Le-Niculescu, S. M. Kurian, N. Yehyawi, C, Dike, S.D. Patel, H. J. Edenberg, M. T. Tsuang, D. R. Salomon, J. I. Nurnberger and A. B. Niculescu, “Identifying Blood Biomarkers for Mood Disorders Using Convergent Functional Genomics,” Molecular Psychiatry, Vol. 14, 2009, pp. 1-19.
[15] I. Hajimohammadreza, M. J. Brammer, S. Eagger, A. Burns and R. Levy, “Platelet and Erythrocyte Membrane Changes in Alzheimer’s Disease,” Biochimica et Biophysica Acta, Vol. 1025, 1990, pp. 208-214. doi:10.1016/0005-2736(90)90099-A
[16] G. S. Zubenko, B. M. Cohen, C. F. Reynolds, F. Boller, I. Malinakova and N. Keefe, “Platelet Membrane Fluidity in Alzheimer’s Disease and Major Depression,” American Journal of Psychiatry, Vol. 44, 1987, pp. 860-868.
[17] I. A. Zainaghi, O. V. Forlenza and W. F. Gattaz, “Abnormal APP Processing in Platelets of Patients with Alzheimer’s Disease: Correlations with Membrane Fluidity and Cognitive Decline,” Psychopharmacology, Vol. 192, No. 4, 2007, pp. 547-553. doi:10.1007/s00213-007-0748-5
[18] M. Giacomini, C. Ruggiero, S. Bertone and L. Calegari, “Artificial Neural Network Identification of Heterotrophic Marine Bacteria Based on Their Fatty-Acid Composition,” IEEE Transactions on Biomedical Engineering, Vol. 44, No. 12, 1997, pp. 1185-1191. doi:10.1109/10.649990
[19] P. A. Noble, J. S. Almeida and C. R. Lovell, “Application of Neural Computing Methods for Interpreting Phospholipid Fatty Acid Profiles of Natural Microbial Communities,” Applied and Environmental Microbiology, Vol. 66, No. 2, 2000, pp. 694-699. doi:10.1128/AEM.66.2.694-699.2000
[20] T. Kohonen, “Self Organizing Maps,” 3rd Edition, Springer-Verlag, Berlin, 2000.
[21] E. Stachowska, I. Gutowska, B. Do?egowska, D. Chlubek, J. Bober, M. Ra?, P. Gutowski, H. Szumilowicz and R. Turowski, “Exchange of Unsaturated Fatty Acids between Adipose Tissue and Atherosclerotic Plaque Studied with Artificial Neural Networks,” Prostaglandins Leukot Essent Fatty Acids, Vol. 70, No. 1, 2004, pp. 59-66. doi:10.1016/j.plefa.2003.08.021
[22] E. Stachowska, I. Gutowska, A. Strzelczak, T. Weso?owska, K. Safranow, K. Ciechanowski and D. Chlubek, “The Use of Neural Networks in Evaluation of the Direction and Dynamics of Changes in Lipid Parameters in Kidney Transplant Patients on the Mediterranean Diet,” Journal of Renal Nutrition, Vol. 16, No. 2, 2006, pp. 150159. doi:10.1053/j.jrn.2006.01.003
[23] E. Stachowska, I. Gutowska, H. Szumi?owicz, J. Bober and D. Chlubek, “Is Conjugated Linoleic Acid (CLA) a Protective Factor in Atherosclerosis? Study with the Use of Neural Networks,” Annales Academiae Medicae Stetinensis, Vol. 51, No. 2, 2005, pp. 27-32.
[24] M. Cocchi, L. Tonello, S. Tsaluchidu and B. K. Puri, “The Use of Artificial Neural Networks to Study Fatty Acids in Neuropsychiatric Disorders,” BMC Psychiatry, Vol. 8, Suppl. 1, S3, 2008. doi:10.1186/1471-244X-8-S1-S3
[25] M. Cocchi and L. Tonello, “Bio Molecular Considerations in Major Depression and Ischemic Cardiovascular Disease,” Central Nervous System Agents in Medicinal Chemistry, Vol. 10, No. 2, 2010, pp. 97-107.
[26] M. Cocchi and L. Tonello, “The Cell Membrane: Is It a Bridge from Psychiatry to Quantum Consciousness?” NeuroQuantology, Vol. 8, No. 1, 2010, pp. 54-60.
[27] D. S. Heron, M. Shinitzky, M. Hershkowitz and D. Samuel, “Lipid Fluidity Markedly Modulates the Binding of Serotonin to Mouse Brain Membranes,” Proceedings of the National Academy of Sciences, Vol. 77, 1980, pp. 7463-7467. doi:10.1073/pnas.77.12.7463
[28] R. E. Lee, “Membrane Engineering to Rejuvenate the Ageing Brain,” Canadian Medical Association Journal, Vol. 132, 1985, pp. 325-327.
[29] M. Cocchi, L. Tonello, A. De Lucia and P. Amato, “Platelet and Brain Fatty Acids: A Model for the Classification of the Animals? Part 1,” International Journal of Anthropology, Vol. 24, No. 1, 2009, pp. 69-76.
[30] M. Cocchi, L. Tonello, A. De Lucia and P. Amato, “Platelet and Brain Fatty Acids: a Model for the Classification of the Animals? Part 2. Platelet and Brain Fatty Acid Transfer: Hypothesis on Arachidonic Acid and its relationship to Major Depression,” International Journal of Anthropology, Vol. 24, No. 3, 2009, pp. 201-220.
[31] P. Green, I. Gispan-Herman and G. Yadid, “Increased Arachidonic Acid Concentration in the Brain of Flinders Sensitive Line Rats, an Animal Model of Epression,” Journal of Lipid Research, Vol. 46, 2005, pp. 1093-1096. doi:10.1194/jlr.C500003-JLR200
[32] H. Tiemeier, H. R. Tuijl, A. Hofman, A. J. Kiliaan and M. M. B. Breteler, “Plasma Fatty Acid Composition and depression Are Associated in the Elderly: The Rotterdam Study 1,” American Journal of Clinical Nutrition, Vol. 78, 2003, pp. 40-46.
[33] M. Cocchi, F. Gabrielli, L. Tonello and M. Pregnolato, “The Interactome Hypothesis of Depression,” NeuroQuantology, Vol. 4, 2010, pp. 603-613.
[34] M. Cocchi, L. Tonello and G. Lercker, “Fatty Acids, Membrane Viscosity, Serotonin and Ischemic Heart Disease,” Lipids in Health and Disease, Vol. 9, 2010, p. 97. doi:10.1186/1476-511X-9-97
[35] M. Cocchi, L. Tonello, F. Gabrielli and M. Pregnolato, “Biological and Anthropological-Existential Hypothesis on Depression,” Quantum Biosystems, Vol. 3, No. 1, 2011, pp. 12-18.
[36] M. Cocchi, L. Tonello, F. Gabrielli, M. Pregnolato and E. Pessa, “Quantum Human & Animal Consciousness: A Concept Embracing Philosophy, Quantitative Molecular Biology & Mathematics,” Journal of Consciousness Exploration & Research, Vol. 2, 2011, pp. 547-574.
[37] M. Cocchi, F. Gabrielli, L. Tonello and M. Pregnolato, “Consciousness and Hallucinations: Molecular Considerations and Theoretical Questions,” NeuroQuantology, Vol. 9, 2011, pp. 182-189.
[38] M. Cocchi, F. Gabrielli, L. Tonello and M. Pregnolato, “Depression, Osteoporosis, Serotonin and Cell Membrane Viscosity between Biology and Philosophical Anthropology,” Annals of General Psychiatry, Vol. 10, 2011, p. 9. doi:10.1186/1744-859X-10-9
[39] M. Cocchi, L. Sardi, L. Tonello and G. Martelli, “Do Mood Disorders Play a Role on Pig Welfare?” Italian Journal of Animal Science, Vol. 8, 2009, pp. 691-704.
[40] M. Cocchi, L. Tonello and F. Gabrielli, “The Animal Side of Mood Disorders,” Lambert Academic Publishing, Saarbrücken, 2001.
[41] G. J. Nelson, P. C. Schmidt, G. Bartolini, D. S. Kelley and D. Kyle, “The Effect of Dietary Arachidonic Acid on Platelet Function, Platelet Fatty Acid Composition, and Blood Coagulation in Humans,” Lipids, Vol. 32, No. 4, 1997, 421-425. doi:10.1007/s11745-997-0055-7
[42] R. Pamplona, G. Barja and M. Portero-Otín, “Membrane Fatty Acid Unsaturation, Protection against Oxidative Stress, and Maximum Life Span,” Annals of the New York Academy of Sciences, Vol. 959, 2006, pp. 475-490. doi:10.1111/j.1749-6632.2002.tb02118.x
[43] C. L. Quilter, C. L. Gilbert, G. L. Oliver, O. Jafer, R. A. Furlong, S. C. Blott, A. E. Wilson, C. A. Sargent, A. Mileham and N. A. Affara, “A Model for Puerperal Psychosis,” American Journal of Medical Genetics, Part B, Vol. 147B, 2008, pp. 1126-1137. doi:10.1002/ajmg.b.30734
[44] A. Rex, J. P. Voigt, K. M. Wicke and H. Fink, “In Vivo/ex Vivo and Behavioural Study on Central Effects of 5-HT1B/1D and 5-HT1A Antagonists in Guinea Pigs,” Pharmacology Biochemistry & Behavior, Vol. 88, No. 3, 2008, pp. 196-204. doi:10.1016/j.pbb.2007.07.016
[45] D. H. Overstreet, J. Stemmelin and G. Griebel, “Confirmation of Antidepressant Potential of the Selective Beta3 Adrenoceptor Agonist Amibegron in an Animal Model of Depression,” Pharmacology Biochemistry & Behavior, Vol. 89, No. 4, 2008, pp. 623-626. doi:10.1016/j.pbb.2008.02.020
[46] D. Owen and S. G. Matthews, “Repeated Maternal Glico Corticoid Treatment Affects Activity and Hippocampal NMDA Receptor Expression in Juvenile Guinea Pigs,” Physiology, Vol. 578, No. 1, 2007, pp. 249-257. doi:10.1113/jphysiol.2006.122887
[47] C. Belzung and G. Griebel, “Measuring Normal and Pathological Anxiety-Like Behaviour in Mice: A Review,” Behavioural Brain Research, Vol. 125, 2001, pp. 141-140. doi:10.1016/S0166-4328(01)00291-1
[48] G. Griebel, “5-Hydroxytryptamine-Interacting Drugs in Animal Models of Anxiety Disorders: More than 30 Years of Research,” Pharmacology & Therapeutics, Vol. 65, 1995, pp. 319-395. doi:10.1016/0163-7258(95)98597-J
[49] M. Boberg, L. B. Croon, I. B. Gustafsson and B. Vessby, “Platelet Fatty Acid Composition in Relation to Fatty Acid Composition in Plasma and to Serum Lipoprotein Lipids in Healthy Subjects with Special Reference to the linoleic acid pathway,” Clinical Science, Vol. 68, No. 5, 1985, pp. 581-587.
[50] P. K. Schick and X. L. He, “Composition and Synthesis of Glycolipids in Megakaryocytes and Platelets: Differences in Synthesis in Megakaryocytes at Different Stages of Maturation,” Journal of Lipid Research, Vol. 31, 1990, pp. 1645-1654.
[51] B. P. Schick and P. K. Schick, “Lipid Composition of Guinea Pig Platelets and Megakaryocytes. The Megakaryocyte as a Probable Source of Platelet Lipids,” Biochimica et Biophysica Acta, Vol. 663, 1981, pp. 239-248.
[52] P. K. Schick, K. Williams-Gartner and X. L. He, “Lipid Composition and Metabolism in Megakaryocytes at Different Stages of Maturation,” Journal of Lipid Research, Vol. 31, 1990, pp. 27-35.
[53] K. Karg, M. Burmeister, K. Shedden and S. Sen, “The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited,” Arch Gen Psychiatry, Vol. 68, 2011, pp. 444-454. doi:10.1001/archgenpsychiatry.2010.189

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