CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals

Ramaseri Sunder Sharada, Hanumanth Surekha Rani, Satya Sudheer Pydi, Jonnalagada Subbanna, Vijaya lakshmi Valluri

1Immunology and Molecular Biology Division, LEPRA India-Blue Peter Public Health & Research Centre, Hyderabad, India.
Department of Genetics, Osmania University, Hyderabad, India.
Immunology and Molecular Biology Division, LEPRA India-Blue Peter Public Health & Research Centre, Hyderabad, India.

DOI: 10.4236/oji.2012.22008                

Abstract

CD38 expression on CD8+ cells seems to correlate well with HIV viral-loads, while the ex-pression levels are thought to be low in patients with tuberculosis. This study aimed at determining the levels of CD38 expression in HIV+ individuals who develop tuberculosis. Expression levels of CD8 and CD38 were analysed in peripheral blood collected from HIV (73), TB (32), HIV-TB (31) and healthy controls (20). The percentage of CD8+/CD38+ cells significantly increased during the first few years of seropositivity and decreased during 5 - 6 years. A decline in the expression of CD38, especially on CD8+ cells in a HIV+ individual within first 2 years of seropositivity, may be indicative of susceptibility to tuberculosis. This observation was reiterated when two patients developed TB during follow-up. CD38 on CD8 cells could perhaps be useful as an early biomarker for tuberculosis in HIV-positive individuals.

Keywords

HIV-TB; CD38; CD8; CD4; Viral Load

Conflicts of Interest

The authors declare no conflicts of interest.

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