Vilsmeier Haack Adducts as Effective Reagents for Regioselective Nitration of Aromatic Compounds under Conventional and Non-Conventional Conditions

Kamatala Chinna Rajanna, Mukka Satish Kumar, Purugula Venkanna, Soma Ramgopal, Marri Venkateswarlu

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DOI: 10.4236/ijoc.2011.14036                

Abstract

Nitration of aromatic Compounds is triggered by Vilsmeier-Haack reagent (DMF/POCl3) or (DMF/SOCl2) in the presence of KNO3 or NaNO2 under conventional and non-conventional conditions. The reactions af- forded corresponding Nitro derivatives in very good yield with high regioselectivity. The results obtained in non-conventional methods (Micro wave irradiation, Grinding, Sonication) are comparable with those ob- tained under conventional conditions, but the reaction times of former conditions are substantially shorter than that of the latter.

Keywords

Nitration, KNO3 or NaNO2, Vilsmeier-Haack Reagent, Microwave Irradiation (MWI), Grinding, Sonication

Conflicts of Interest

The authors declare no conflicts of interest.

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