[1]
|
Improving Supportive and Palliative Care for Adults with Cancer—The Manual. National Institute for Clinical Excellence. https://www.nice.org.uk/guidance/csg4
|
[2]
|
Zafar, S.Y., Currow, D.C., Cherny, N., et al. (2012) Consensus-Based Standards for Best Supportive Care in Clinical Trials in Advanced Cancer. The Lancet Oncology, 13, e77-e82. https://doi.org/10.1016/S1470-2045(11)70215-7
|
[3]
|
Cancer Supportive Care Drugs Market Size US$ 21.8 Bn by 2026. https://www.globenewswire.com/news-release/2019/07/02/1877384/0/en/Cancer-Supportive-Care-Drugs-Market-Size-US-21-8-Bn-by-2026.html
|
[4]
|
Cancer Treatment and Survivorship, Facts and Figures 2019-2021. American Cancer Society. https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/cancer-treatment-and-survivorship-facts-and-figures/cancer-treatment-and-survivorship-facts-and-figures-2019-2021.pdf
|
[5]
|
Rohdenburg (1918) Fluctuations in the Growth Energy of Tumors in Man, with Esspecial Reference to Spontaneous Recession. Journal of Cancer Research, 3, 193-225.
|
[6]
|
Fauvet, J. (1964) Spontaneous Cancer Cures and Regressions. Revue du Praticien, 14, 2177-2180.
|
[7]
|
Boyd, W. (1966) The Spontaneous Regression of Cancer. Charles Thomas, Springfield.
|
[8]
|
O’Regan, B. and Hirschberg, C. (1993) Spontaneous Remission: An Annotated Bibliography. Institute of Noetic Sciences, Sausalito.
|
[9]
|
Hobohm, U. (2005) Fever Therapy Revisited. British Journal of Cancer, 92, 421-425. https://doi.org/10.1038/sj.bjc.6602386
|
[10]
|
Cole, W.H. (1976) Spontaneous Regression of Cancer and the Importance of Finding Its Cause. National Cancer Institute Monographs No. 44, 5-9.
|
[11]
|
Hobohm, U., Grange, J. and Stanford, J. (2008) Pathogen Associated Molecular Pattern in Cancer Immunotherapy. Critical Reviews Immunology, 28, 95-107. https://doi.org/10.1615/CritRevImmunol.v28.i2.10
|
[12]
|
Zahl, P.H., Mæhlen, J. and Welch, H.G. (2008) The Natural History of Invasive Breast Cancers Detected by Screening Mammography. Archives of Internal Medicine, 168, 2311-2316. https://doi.org/10.1001/archinte.168.21.2311
|
[13]
|
Cole, W.H. and Everson, T.C. (1966) Spontaneous Regression of Cancer. WB Saunders, Philadelphia.
|
[14]
|
Everson, T. and Cole, W. (1968) Spontaneous Regression of Cancer. JB Saunder & Co., Philadelphia.
|
[15]
|
Challis, G.B. and Stam, H.J. (1990) The Spontaneous Regression of Cancer. A Review of Cases from 1900-1987. Acta Oncologica, 29, 545-550. https://doi.org/10.3109/02841869009090048
|
[16]
|
Hobohm, U. (2001) Fever and Cancer in Perspective. Cancer Immunology, Immunotherapy, 50, 391-396. https://doi.org/10.1007/s002620100216
|
[17]
|
Coffey, D.S., Getzenberg, R.H. and DeWeese, T.L. (2006) Hyperthermic Biology and Cancer Therapies: A Hypothesis for the “Lance Armstrong Effect”. JAMA, 296, 445-448. https://doi.org/10.1001/jama.296.4.445
|
[18]
|
Kocasli, S. and Demircan, Z. (2017) Herbal Product Use by the Cancer Patients in Both Pre and Post Surgery Periods and during Chemotherapy. African Journal of Traditional, Complementary, and Alternative Medicines, 14, 325-333. https://doi.org/10.21010/ajtcam.v14i2.34
|
[19]
|
McCune, J.S., Hatfield, A.J., Blackburn, A.A.R., et al. (2004) Potential of Chemotherapy-Herb Interactions in Adult Cancer Patients. Supportive Care in Cancer, 12, 454-462. https://doi.org/10.1007/s00520-004-0598-1
|
[20]
|
Weiger, W.A., Smith, M., Boon, H., Richardson, M.A., Kaptchuk, T.J. and Eisenberg, D.M. (2002) Advising Patients Who Seek Complementary and Alternative Medical Therapies for Cancer. Annals of Internal Medicine, 137, 889-903. https://doi.org/10.7326/0003-4819-137-11-200212030-00010
|
[21]
|
Sanson, Fisher, R., Girgis, A., Boyes, A., et al. (2000) The Unmet Supportive Care Needs of Patients with Cancer. Cancer, 88, 226-237. https://doi.org/10.1002/(SICI)1097-0142(20000101)88:1<226::AID-CNCR30>3.0.CO;2-P
|
[22]
|
O’Connor, M., Drummond, F., et al. (2019) The Unmet Needs of Cancer Survivors in Ireland: A Scoping Review. Irish Cancer Society. https://www.cancer.ie
|
[23]
|
Boullata, J.I. and Hudson, L.M. (2012) Drug-Nutrient Interactions: A Broad View with Implications for Practice. Journal of the Academy of Nutrition and Dietetics, 112, 506-517. https://doi.org/10.1016/j.jada.2011.09.002
|
[24]
|
Fradgley, E.A., Bultz, B.D., Kelly, B.J., et al. (2019) Progress toward Integratingdistress as the Sixth Vital Sign: A Global Snapshot of Triumphs and Tribulations in Precision Supportive Care. Journal of Psychosocial Oncology Research and Practice, 1, e2. https://doi.org/10.1097/OR9.0000000000000002
|
[25]
|
Fielding, R., Lam, W.W., Shun, S.C., Okuyama, T., Lai, Y.H., Wada, M., Akechi, T. and Li, W.W. (2013) For Asia-Pacific Psycho-Oncology Network (APPON) Attributing Variance in Supportive Care Needs during Cancer: Culture-Service, and Individual Differences before Clinical Factors. PLOS ONE, 8, e65099. https://doi.org/10.1371/journal.pone.0065099
|
[26]
|
Need for Supportive Care in Oncology Will Increase during the Next Decade, 13 February 2018. https://www.globaldata.com/need-supportive-care-oncology-will-increase-next-decade
|
[27]
|
Bonevski, B., et al. (2000) Evaluation of an Instrument to Assess the Needs of Patients with Cancer. Supportive Care Review Group. Cancer, 88, 217-225. https://doi.org/10.1002/(SICI)1097-0142(20000101)88:1<217::AID-CNCR29>3.0.CO;2-Y
|
[28]
|
Chan, A., Lees, J. and Keefe, D. (2014) The Changing Paradigm for Supportive Care in Cancer Patients. Supportive Care in Cancer, 22, 1441-1445. https://doi.org/10.1007/s00520-014-2229-9
|
[29]
|
Seow, H. and Bainbridge, B. (2017) A Review of the Essential Components of Quality Palliative Care in the Home. Journal of Palliative Medicine, 20, S37-S44. https://doi.org/10.1089/jpm.2017.0392
|
[30]
|
Johnson, S.B., Butow, P.N., Bell, M.L., et al. (2018) A Randomized Controlled Trial of an Advance Care Planning Intervention for Patients with Incurable Cancer. British Journal of Cancer, 119, 1182-1190. https://doi.org/10.1038/s41416-018-0303-7
|
[31]
|
Glare, P.A. (2013) Early Implementation of Palliative Care Can Improve Patient Outcomes. Journal of National Comprehensive Cancer Network, 11, S3-S9. https://doi.org/10.6004/jnccn.2013.0212
|
[32]
|
Thomas, K. (2003) Caring for the Dying at Home. Companions on a Journey. Radcliffe Medical Press, Oxford.
|
[33]
|
Kaasa, S., Loge, J.H., Aapro, M., et al. (2018) Integration of Oncology and Palliative Care: A Lancet Oncology Commission. The Lancet Oncology, 19, E588-E653. https://doi.org/10.1016/S1470-2045(18)30415-7
|
[34]
|
Smyth, J.F. (2008) Disclosing Gaps between Supportive and Palliative Care—The Past 20 Years. Supportive Care in Cancer, 16, 109-111. https://doi.org/10.1007/s00520-007-0354-4
|
[35]
|
West, B.J. (2006) Where Medicine Went Wrong: Rediscovering the Path to Complexity. World Scientific, London. https://doi.org/10.1142/6175
|
[36]
|
Senn, H.J., Glaus, A. and Schmid, L. (1988) Supportive Care in Cancer Patients. Springer-Verlag, Berlin. https://doi.org/10.1007/978-3-642-82932-1
|
[37]
|
Palliative Care Definition by WHO. https://www.who.int/cancer/palliative/definition/en
|
[38]
|
Nwosu, A.C., Sturgeon, B., McGlinchey, T., et al. (2019) Rotobic Technology for Palliative and Supportive Care: Strengths, Weaknesses, Opportunities and Threats. Paliative Medicine, 33, 1106-1113. https://doi.org/10.1177/0269216319857628
|
[39]
|
Keefe, D., Garni, A., Villalon, A., et al. (2016) Challenges in Supportive Cancer Care: Perspectives from the Asia Pacific and Middle East. Supportive Care in Cancer, 24, 4479-4481. https://doi.org/10.1007/s00520-016-3381-1
|
[40]
|
Keefe, D.M. and Bateman, E.H. (2012) Tumor Control versus Adverse Events with Targeted Anticancer Therapies. Nature Reviews Clinical Oncology, 9, 98-109. https://doi.org/10.1038/nrclinonc.2011.192
|
[41]
|
Chan, A., Chiang, Y.Y., Low, X.H., et al. (2013) Affordability of Cancer Treatment for Aging Cancer Patients in Singapore: An Analysis of Health, Lifestyle, and Financial Burden. Supportive Care in Cancer, 21, 3509-3517. https://doi.org/10.1007/s00520-013-1930-4
|
[42]
|
Brower, V. (2016) Hyperprogressive Disease with Anti-PD-1 and Anti-PD-L1. Clinical Cancer Research, 17, e527. https://doi.org/10.1016/S1470-2045(16)30590-3
|
[43]
|
Gelao, L., Criscitiello, C., Esposito, A., et al. (2014) Immune Checkpoint Blockade in Cancer Treatment: A Double-Edged Sword Cross-Targeting the Host as an “Innocent Bystander”. Toxins, 6, 914-933. https://doi.org/10.3390/toxins6030914
|
[44]
|
Sikora, K., Advani, S., Koroltchouk, V., et al. (1999) Essential Drugs for Cancer Therapy: A World Health Organization Consultation. Annals of Oncology, 10, 385-390. https://doi.org/10.1023/A:1008367822016
|
[45]
|
Markiewski, M.M. and Lambris, J.D. (2009) Is Complement Good or Bad for Cancer Patients? A New Perspective on an Old Dilemma. Trends in Immunology, 30, 286-292. https://doi.org/10.1016/j.it.2009.04.002
|
[46]
|
MacDonald, N. (2007) Cancer Cachexia and Targeting Chronic Inflammation: A Unified Approach to Cancer Treatment and Palliative/Supportive Care. The Journal of Supportive Oncology, 5, 157-162.
|
[47]
|
Barni, S., Lissoni, P., Cazzaniga, M., et al. (1995) A Randomized Study of Low-Dose Subcutaneous Interleukin-2 plus Melatonin versus Supportive Care Alone in Metastatic Colorectal Cancer Patients Progressing under 5-Fluorouracil and Folates. Oncology, 52, 243-245. https://doi.org/10.1159/000227465
|
[48]
|
Kleckner, A.S., Kleckner, I.R., Kamen, C.S., et al. (2019) Opportunities for Cannabis in Supportive Care in Cancer. Therapeutic Advances in Medical Oncology, 11, 1-29. https://doi.org/10.1177/1758835919866362
|
[49]
|
Welsh Assembly Government (2001) Improving Health in Wales: A Plan for the NHS with Its Partners. Welsh Assembly Government, Cardiff.
|
[50]
|
Irwin, K.E., Greer, J.A., Khatib, J., et al. (2013) Early Palliative Care and Metastatic Non-Small Cell Lung Cancer: Potential Mechanisms of Prolonged Survival. Chronic Respiratory Disease, 10, 35-47. https://doi.org/10.1177/1479972312471549
|
[51]
|
Leutz, W.N. (1999) Five Laws for Integrating Medical and Social Services: Lessons from the United States and the United Kingdom. The Milbank Quarterly, 77, 77-110. https://doi.org/10.1111/1468-0009.00125
|
[52]
|
Haun, M.W., Estel, S., Rücker, G., et al. (2017) Early Palliative Care for Adults with Advanced Cancer. Cochrane Database of Systematic Reviews, 6, CD011129. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011129.pub2/abstract
|
[53]
|
Hui, D., Elsayem, A., DelaCruz, M., et al. (2010) Availability and Integration of Palliative Care at US Cancer Centers. JAMA, 303, 1054-1061. https://doi.org/10.1001/jama.2010.258
|
[54]
|
Gelfman, L.P. and Morrison, R.S. (2008) Research Funding for Palliative Medicine. Journal of Palliative Medicine, 11, 36-43. https://doi.org/10.1089/jpm.2006.0231
|
[55]
|
Abrahm, J.L. (2012) Integrating Palliative Care into Comprehensive Cancer Care. Journal of the National Comprehensive Cancer Network, 10, 1192-1198. https://doi.org/10.6004/jnccn.2012.0126
|
[56]
|
Goldsmith, B., Dietrich, J., Du, Q., et al. (2008) Variability in Access to Hospital Palliative Care in the United States. Journal of Palliative Medicine, 11, 1094-1102. https://doi.org/10.1089/jpm.2008.0053
|
[57]
|
Morrison, R.S., Augustin, R., Souvanna, P., et al. (2011) America’s Care of Serious Illness: A State-by-State Report Card on Access to Palliative Care in Our Nation’s Hospitals. Journal of Palliative Medicine, 14, 1094-1096. https://doi.org/10.1089/jpm.2011.9634
|
[58]
|
Howie, L. and Peppercorn, J. (2013) Early Palliative Care in Cancer Treatment: Rationale, Evidence and Clinical Implications. Therapeutic Advances in Medical Oncology, 5, 318-323. https://doi.org/10.1177/1758834013500375
|
[59]
|
Kamal, A.H., Gradison, M., Maguire, J.M., et al. (2014) Quality Measures for Palliative Care in Patients with Cancer: A Systematic Review. Journal of Oncology Practice, 10, 281-287. https://doi.org/10.1200/JOP.2013.001212
|
[60]
|
Portman, D. and Thirlwell, S. (2015) Perspectives, Progress and Opportunities for Palliative Care in Oncology. Cancer Control, 22, 382-384. https://doi.org/10.1177/107327481502200402
|
[61]
|
Ramchandran, K., Tribett, E., Dietrich, B., et al. (2015) Integrating Palliative Care into Oncology: A Way Forward. Cancer Control, 22, 386-395. https://doi.org/10.1177/107327481502200404
|
[62]
|
Smith, T.J., Temin, S., Alesi, E.R., et al. (2012) American Society of Clinical Oncology Provisional Clinical Opinion: The Integration of Palliative Care into Standard Oncology Care. Journal of Clinical Oncology, 30, 880-887. https://doi.org/10.1200/JCO.2011.38.5161
|
[63]
|
American Society of Clinical Oncology (1998) Cancer Care during the Last Phase of Life. Journal of Clinical Oncology, 16, 1986-1996. https://doi.org/10.1200/JCO.1998.16.5.1986
|
[64]
|
Cherny, N., Catane, R., Schrijvers, D., et al. (2010) European Society for Medical Oncology (ESMO) Program for the Integration of Oncology and Palliative Care: A 5-Year Review of the Designated Centers’ Incentive Program. Annals of Oncology, 21, 362-369. https://doi.org/10.1093/annonc/mdp318
|
[65]
|
Kamal, A.H., Harrison, K.L., Bakitas, M., et al. (2015) Improving the Quality of Palliative Care through National and Regional Collaboration Efforts. Cancer Control, 22, 396-402. https://doi.org/10.1177/107327481502200405
|
[66]
|
Jacobsen, P.B. and Lee, M. (2015) Integrating Psychosocial Care into Routine Cancer Care. Cancer Control, 22, 442-449. https://doi.org/10.1177/107327481502200410
|
[67]
|
Baitas, M.A., Elk, R., Astin, M., et al. (2015) Systematic Review of Palliative Care in the Rural Setting. Cancer Control, 22, 450-464. https://doi.org/10.1177/107327481502200411
|
[68]
|
Hui, D. (2015) Prognostication of Survival in Patients with Advanced Cancer: Predicting the Unpredictable? Cancer Control, 22, 489-497. https://doi.org/10.1177/107327481502200415
|
[69]
|
Tassinari, D., Montanari, L., Maltoni, M., et al. (2008) The Palliative Prognostic Score and Survival in Patients with Advanced Solid Tumors Receiving Chemotherapy. Supportive Care in Cancer, 16, 359-370. https://doi.org/10.1007/s00520-007-0302-3
|
[70]
|
Morita, T., Tsunoda, J., Inoue, S., et al. (1999) The Palliative Prognostic Index: A Scoring System for Survival Prediction of Terminally Ill Cancer Patients. Supportive Care in Cancer, 7, 128-133. https://doi.org/10.1007/s005200050242
|
[71]
|
Miura, T., Matsumoto, Y., Hama, T., et al. (2015) Glasgow Prognostic Score Predicts Prognosis for Cancer Patients in Palliative Settings: A Subanalysis of the Japan-Prognostic Assessment Tools Validation (J-Proval) Study. Supportive Care in Cancer, 23, 3149-3156. https://doi.org/10.1007/s00520-015-2693-x
|
[72]
|
Calaprice, A. (2011) The Ultimate Quotable Einstein. Princeton University Press, Princeton.
|
[73]
|
Szentgyorgyi, A. (1978) The Living State and Cancer. Marcel Dekker Inc., New York.
|
[74]
|
Yamagata, T., Nakamura, Y., Yamagata, Y., et al. (2003) The Pilot Trial of the Prevention of the Increase in Electrical Taste Thresholds by Zinc Containing Fluid Infusion during Chemotherapy to Treat Primary Lung Cancer. Journal of Experimental & Clinical Cancer Research, 22, 557-563.
|
[75]
|
Sieja, K. and Talerczyk, M. (2004) Selenium as an Element in the Treatment of Ovarian Cancer in Women Receiving Chemotherapy. Gynecologic Oncology, 93, 320-327. https://doi.org/10.1016/j.ygyno.2003.12.013
|
[76]
|
Freedman, M.R., King, J. and Kennedy, E. (2001) Popular Diets: A Scientific Review. Obesity Research, 9, 1S-40S. https://doi.org/10.1038/oby.2001.113
|
[77]
|
Michael, M. (2018) Comparative Studies of Energy Homeostasis in Vertebrates. Frontiers in Endocrinology and Frontiers in Neurosciesnce, 9, Article No. 291. https://doi.org/10.3389/978-2-88945-560-7
|
[78]
|
Cherif, A.O. (2012) Phytochemicals Components as Bioactive Foods. In: Rasooli, I., Ed., Bioactive Compounds in Phytomedicine, IntechOpen, London, 113-124. https://www.intechopen.com/books/bioactive-compounds-in-phytomedicine/phytochemicals-components-as-bioactive-foods
|
[79]
|
Sajjad, M., Khan, A., Ahmad, I. and Chattopadhyay, D. (2019) New Look to Phytomedicine, Advancements in Herbal Products as Novel Drug Leads. Elsevier, Amsterdam.
|
[80]
|
Pandey, M., Debnath, M., Gupta, S., et al. (2011) Phytomedicine: An Ancient Approach Turning into Future Potential Source of Therapeutics. Journal of Pharmacognosy and Phytotherapy, 3, 113-117.
|
[81]
|
Hegyi, G., Vincze, G. and Szasz, A. (2012) On the Dynamic Equilibrium in Homeostasis. Open Journal of Biophysics, 2, 64-71. https://doi.org/10.4236/ojbiphy.2012.23009
|
[82]
|
Barbosa, W.L.R., Pinto, L., Malheiros, L.C.S., Barros, P.M.S.S., de Freitas, C.B., Silva, J.O.C., Gallori, S. and Vincieri, F.F. (2012) Standardization of Herbal Drugs Derivatives with Special Reference to Brazilian Regulations. In: Rasooli, I., Ed., Bioactive Compounds in Phytomedicine, InTechOpen, London, 69-92. http://www.intechopen.com/books/bioactive-compounds-inphytomedicine/standardization-of-herbal-drugs-derivatives-with-special-reference-to-brazilian-regulations
|
[83]
|
Lampe, J.W. and Chang, J.L. (2007) Interindividual Differences in Phytochemical Metabolism and Disposition. Seminars in Cancer Biology, 17, 347-353. https://doi.org/10.1016/j.semcancer.2007.05.003
|
[84]
|
Boik, J. (2001) Natural Compounds in Cancer Therapy. Quality Books, Inc., Oregon.
|
[85]
|
Cory, H., Passarelli, S., Szeto, J., et al. (2018) The Role of Polyphenols in Human Health and Food Systems: A Mini-Review. Frontiers in Nutrition, 5, Article No. 87. https://doi.org/10.3389/fnut.2018.00087
|
[86]
|
Oparam, E.I. and Chohan, M. (2014) Culinary Herbs and Spices: Their Bioactive Properties the Contribution of Polyphenols and the Challenges in Deducing Their True Health Benefits. International Journal of Molecular Sciences, 15, 19183-19202. https://doi.org/10.3390/ijms151019183
|
[87]
|
Eloe-Fadrosh, E.A. and Rasko, D.A. (2013) The Human Microbiome from Symbiosis to Pathogenesis. Annual Review of Medicine, 64, 145-163. https://doi.org/10.1146/annurev-med-010312-133513
|
[88]
|
Martin, K.R. and Appelm, C.L. (2010) Polyphenols as Dietary Supplements: A Double-Edged Sword. Nutrition and Dietary Supplements, 2, 1-12. https://doi.org/10.2147/NDS.S6422
|
[89]
|
Hooper, B. and Frazier, R. (2012) Polyphenols in the Diet: Friend or Foe? Nutrition Bulletin, 37, 297-308. https://doi.org/10.1111/j.1467-3010.2012.02001.x
|
[90]
|
Afonso, C., Bernardo, I., Bandarra, N.M., Martins, L.L. and Cardoso, C. (2019) The Implications of Following Dietary Advice Regarding Fish Consumption Frequency and Meal Size for the Benefit (EPA+DHA and Se) versus Risk (Mehg) Assessment. International Journal of Food Sciences and Nutrition, 70, 623-637. https://doi.org/10.1080/09637486.2018.1551334
|
[91]
|
Moloudizargari, M., Mortaz, E., Asghari, M.H., et al. (2018) Effects of the Polyunsaturated Fatty Acids, EPA and DHA, on Hematological Malignancies: A Systemic Review. Oncotarget, 9, 11858-11875. https://doi.org/10.18632/oncotarget.24405
|
[92]
|
Serini, S., Fasano, E., Piccioni, E., Cittadini, A.R.M. and Calviello, G. (2011) Differential Anti-Cancer Effects of Purified EPA and DHA and Possible Mechanisms Involved. Current Medicinal Chemistry, 18, 4065-4075. https://doi.org/10.2174/092986711796957310
|
[93]
|
Buttigliero, C., Monagheddu, C., Petroni, P., et al. (2011) Prognostic Role of Vitamin D Status and Efficacy of Vitamin D Supplementation in Cancer Patients: A Systematic Review. Oncologist, 16, 1215-1227. https://doi.org/10.1634/theoncologist.2011-0098
|
[94]
|
Zhang, Y., Fang, F., Tang, J., et al. (2019) Association between Vitamin D Supplementation and Mortality: Systematic Review and Meta-Analysis. BMJ, 366, l4673. https://doi.org/10.1136/bmj.l4673
|
[95]
|
Hu, K., Callen, D.F., Li, J. and Zheng, H. (2018) Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies. Integrative Cancer Therapies, 17, 217-225. https://doi.org/10.1177/1534735417712007
|
[96]
|
Estébanez, N., Gómez, A.I., Palazuelos, C., et al. (2018) Vitamin D Exposure and Risk of Breast Cancer: A Meta-Analysis. Scientific Reports, 8, Article No. 9039. https://doi.org/10.1038/s41598-018-27297-1
|
[97]
|
Hossain, S., Beydoun, M.A., Beydoun, H.A., et al. (2019) Vitamin D and Breast Cancer: A Systematic Review and Meta-Analysis of Observational Studies. Clinical Nutrition ESPEN, 30, 170-184. https://doi.org/10.1016/j.clnesp.2018.12.085
|
[98]
|
Zhang, L., Wang, S., Che, X. and Li, X. (2015) Vitamin D and Lung Cancer Risk: A Comprehensive Review and Meta-Analysis. Cellular Physiology & Biochemistry, 36, 299-305. https://doi.org/10.1159/000374072
|
[99]
|
Hsueh, T.Y., Baum, J.I. and Huang, Y. (2018) Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation. Frontiers in Nutrition, 5, Article No. 15. https://doi.org/10.3389/fnut.2018.00015
|
[100]
|
Ochi, E. and Tsuchiya, Y. (2018) Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) in Muscle Damage and Function. Nutrients, 10, Article 552. https://doi.org/10.3390/nu10050552
|
[101]
|
Chow, J., Lee, S.M., Shen, Y., et al. (2010) Host-Bacterial Symbiosis in Health and Disease. Advances in Immunology, 107, 243-274. https://doi.org/10.1016/B978-0-12-381300-8.00008-3
|
[102]
|
De la Fuente, M., MacDonald, T.T. and Hermoso, M.A. (2019) Editorial: Intestinal Homeostasis and Disease: A Complex Partnership between Immune Cells, Non-Immune Cells, and the Microbiome. Frontiers in Immunology, 10, Article No. 2775. https://doi.org/10.3389/fimmu.2019.02775
|
[103]
|
Williamson, G. (2017) The Role of Polyphenols in Modern Nutrition. Nutrition Bulletin, 42, 226-235. https://doi.org/10.1111/nbu.12278
|
[104]
|
Morowitz, M.J., Carlisle, E. and Alverdy, J.C. (2011) Contributions of Intestinal Bacteria to Nutrition and Metabolism in the Critically III. Surgical Clinics of North America, 91, 771-785. https://doi.org/10.1016/j.suc.2011.05.001
|
[105]
|
Singh, A.K., Cabral, C., Kumar, R., et al. (2019) Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency. Nutrients, 11, 2216. https://doi.org/10.3390/nu11092216
|
[106]
|
Spagnuolo, C., Russo, G.L., Orhan, I.E., et al. (2015) Genistein and Cancer: Current Status, Challenges, and Future Directions. Advances in Nutrition, 6, 408-419. https://doi.org/10.3945/an.114.008052
|
[107]
|
Wang, S., Li, J., Huang, H., et al. (2009) Anti-Hepatitis B Virus Activities of Astragaloside IV Isolated from Radix Astragali. Biological and Pharmaceutical Bulletin, 32, 132-135. https://doi.org/10.1248/bpb.32.132
|
[108]
|
Wang, Y., Ren, T., Zheng, L., et al. (2016) Astragalus Saponins Inhibits Lipopolysaccharide-Induced Inflammation in Mouse Macrophages. The American Journal of Chinese Medicine, 44, 579-593. https://doi.org/10.1142/S0192415X16500324
|
[109]
|
Shahzad, M., Shabbir, A., Wojcikowski, K., et al. (2016) The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease. Current Drug Targets, 17, 1331-1340. https://doi.org/10.2174/1389450116666150907104742
|
[110]
|
Chu, D.T., Wong, W.L. and Mavligit, G.M. (1988) Immunotherapy with Chinese Medicinal Herbs. II. Reversal of Cyclophosphamide-Induced Immune Suppression by Administration of Fractionated Astragalus membranaceus in Vivo. Journal of Clinical and Laboratory Immunology, 25, 125-129.
|
[111]
|
Martin, A.M., Yabut, J.M., Choo, J.M., et al. (2019) The Gut Microbiome Regulates Host Glucose Homeostasis via Peripheral Serotonin. PNAS, 116, 19802-19804. https://doi.org/10.1073/pnas.1909311116
|
[112]
|
Miller, L.H. and Su, X. (2011) Artemisinin: Discovery from the Chinese Herbal Garden. Cell, 146, 855-858. https://doi.org/10.1016/j.cell.2011.08.024
|
[113]
|
Zipperer, M. (2019) WHO Calls for an Immediate Halt to Provision of Single-Drug Artemisinin Malaria Pills.
|
[114]
|
Chung, V.C.H., Wu, X., Hui, E.P., et al. (2015) Effectiveness of Chinese Herbal Medicine for Cancer Palliative Care: Overview of Systematic Reviews with Meta-Analyses. Scientific Reports, 5, Article No. 18111. https://doi.org/10.1038/srep18111
|
[115]
|
Zhao, X., Zhu, Y., Hu, J., et al. (2018) Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-Mediated Aerobic Glycolysis. Scientific Reports, 8, Article No. 14517. https://doi.org/10.1038/s41598-018-31615-y
|
[116]
|
Chen, J., Xie, J., Jiang, Z., et al. (2011) Shikonin and Its Analogs Inhibit Cancer Cell Glycolysis by Targeting Tumor Pyruvate Kinase-M2. Oncogene, 30, 4297-4306. https://doi.org/10.1038/onc.2011.137
|
[117]
|
James, A.D., Richardson, D.A., Oh, I.W., et al. (2020) Cutting off the Fuel Supply to Calcium Pumps in Pancreatic Cancer Cells: Role of Pyruvate Kinase-M2 (PKM2). British Journal of Cancer, 122, 266-278. https://doi.org/10.1038/s41416-019-0675-3
|
[118]
|
Shilnikova, K., Piao, M.J., Kang, K.A., et al. (2018) Shikonin Induces Mitochondria-Mediated Apoptosis and Attenuates Epithelial-Mesenchymal Transition in Cisplatin-Resistant Human Ovarian Cancer Cells. Oncology Letter, 15, 5417-5424. https://doi.org/10.3892/ol.2018.8065
|
[119]
|
Zhang, H. and Tsao, R. (2016) Dietary Polyphenols, Oxidative Stress and Antioxidant and Anti-Inflammatory Effects. Current Opinion in Food Science, 8, 33-42. https://doi.org/10.1016/j.cofs.2016.02.002
|
[120]
|
(2013) The COVID-19 Outbreak Is an Emerging, Rapidly Evolving Situation. https://nccih.nih.gov/health/antioxidants/introduction.htm
|
[121]
|
Zhou, Y., Zheng, J., Li, Y., Xu, D.P., Li, S., Chen, Y.M., et al. (2016) Natural Polyphenols for Prevention and Treatment of Cancer. Nutrients, 8, 515. https://doi.org/10.3390/nu8080515
|
[122]
|
Fujiki, H., Sueoka, E., Watanabe, T. and Suganuma, M. (2015) Primary Cancer Prevention by Green Tea, and Tertiary Cancer Prevention by the Combination of Green Tea Catechins and Anticancer Compounds. Journal of Cancer Prevention, 20, 1-4. https://doi.org/10.15430/JCP.2015.20.1.1
|
[123]
|
Singh, K., Bhori, M., Kasu, Y.A., et al. (2018) Antioxidants as Precision Weapons in War against Cancer Chemotherapy Induced Toxicity-Exploring the Armoury of Obscurity. Saudi Pharmaceutical Journal, 26, 177-190. https://doi.org/10.1016/j.jsps.2017.12.013
|
[124]
|
Stevenson, D.E. (2012) Polyphenols as Adaptogens—The Real Mechanism of the Antioxidant Effect? In: Rasooli, I., Ed., Bioactive Compounds in Phytomedicine, InTechOpen, London, 143-162. http://www.intechopen.com/books/bioactive-compounds-in-phytomedicine/polyphenols-as-adaptogensthe-real-mechanism-of-the-antioxidant-effect
|
[125]
|
Warburg, O. (1996) Oxygen, the Creator of Differentiation, Biochemical Energetics. In: The Prime Cause and Prevention of Cancer, Academic Press, New York.
|
[126]
|
Warburg, O. (1956) On the Origin of Cancer Cells. Science, 123, 309-314. https://doi.org/10.1126/science.123.3191.309
|
[127]
|
Schulz, T.J., Thierbach, R., Voigt, A., et al. (2006) Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth. The Journal of Biological Chemistry, 281, 977-981. https://doi.org/10.1074/jbc.M511064200
|
[128]
|
Miles, K.A. and Williams, R.E. (2008) Warburg Revisited: Imaging Tumor Blood Flow and Metabolism. Cancer Imaging, 8, 81-86. https://doi.org/10.1102/1470-7330.2008.0011
|
[129]
|
Heiden, M.G.V., Cantley, L.C. and Thompson, C.B. (2009) Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science, 324, 1029-1033. https://doi.org/10.1126/science.1160809
|
[130]
|
Garber, K. (2004) Energy Boost: The Warburg Effect Returns in a New Theory of Cancer. JNCI: Journal of the National Cancer Institute, 96, 1805-1806. https://doi.org/10.1093/jnci/96.24.1805
|
[131]
|
Seyfried, T.N. and Mukherjee, P. (2005) Targeting Energy Metabolism in Brain Cancer: Review and Hypothesis. Nutrition & Metabolism, 2, 30-38. https://doi.org/10.1186/1743-7075-2-30
|
[132]
|
Xiaolong, M. and Riordan, N.H. (2006) Cancer Is a Functional Repair Tissue. Medical Hypotheses, 66, 486-490. https://doi.org/10.1016/j.mehy.2005.09.041
|
[133]
|
Wardman, P. (2001) Electron Transfer and Oxidative Stress as Key Factors in the Design of Drug Selectively Active in Hypoxia. Current Medicinal Chemistry, 8, 739-761. https://doi.org/10.2174/0929867013372959
|
[134]
|
Tracy, K., Dibling, B.C., Spike, B.T., Knabb, J.R., Schumacker, P. and MacLeod, K.F. (2007) BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy. Molecular and Cellular Biology, 27, 6229-6242. https://doi.org/10.1128/MCB.02246-06
|
[135]
|
Al-Mehdi, A.B., Pastukh, V.M., Swiger, B.M., Reed, D.J., Patel, M.R., Bardwell, G.C., et al. (2012) Perinuclear Mitochondrial Clustering Creates Antioxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription. Science Signaling, 5, ra47. https://doi.org/10.1126/scisignal.2002712
|
[136]
|
Boland, M.L., Chourasia, A.H. and Macleod, K.F. (2013) Mitochondrial Dysfunction in Cancer. Frontiers in Oncology, 3, Article No. 292. https://doi.org/10.3389/fonc.2013.00292
|
[137]
|
Wallace, D.C. (2005) Mitochondria and Cancer: Warburg Addressed. Cold Spring Harbour Symposia on Quantitative Biology, 70, 636-649. https://doi.org/10.1101/sqb.2005.70.035
|
[138]
|
Schavemaker, P.E., Boersma, A.J. and Poolman, B. (2018) How Important Is Protein Diffusion in Prokaryotes? Frontiers in Molecular Biosciences, 5, Article No. 293. https://doi.org/10.3389/fmolb.2018.00093
|
[139]
|
Wright, G.D. (2007) On the Road to Bacterial Cell Death. Cell, 130, 781-783. https://doi.org/10.1016/j.cell.2007.08.023
|
[140]
|
Petrelli, F., Ghidini, M., Ghidini, A., et al. (2019) Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies. Cancers, 11, Article 1174. https://doi.org/10.3390/cancers11081174
|
[141]
|
Kim, H., Lee, J.E., Hong, S.H., et al. (2019) The Effect of Antibiotics on the Clinical Outcomes of Patients with Solid Cancer Undergoing Immune Checkpoint Inhibitor Treatment: A Retrospective Study. BMC Cancer, 19, Article No. 21100. https://doi.org/10.1186/s12885-019-6267-z
|
[142]
|
McKee, A., Hall, L.J. and Robinson, S.D. (2019) The Microbiota, Antibiotics and Breast Cancer. Breast Cancer Management, 8, BMT29. https://doi.org/10.2217/bmt-2019-0015
|
[143]
|
Bordonaro, M. (2018) Hypothesis: Cancer Is a Disease of Evolved Trade-Offs between Neoplastic Virulence and Transmission. Journal of Cancer, 9, 1707-1724. https://doi.org/10.7150/jca.24679
|
[144]
|
Medicinal Mushrooms (PDQ®)-Health Professional Version. https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq
|
[145]
|
Wasser, S.P. (2014) Medicinal Mushroom Science: Current Perspectives, Advances, Evidences, and Challenges. Biomedical Journal, 37, 345-356. https://doi.org/10.4103/2319-4170.138318
|
[146]
|
Ng, T.B. (1998) A Review of Research on the Protein-Bound Polysaccharide (Polysaccharopeptide, PSP) from the Mushroom Coriolus Versicolor (Basidiomycetes: Polyporaceae). General Pharmacology, 30, 1-4. https://doi.org/10.1016/S0306-3623(97)00076-1
|
[147]
|
Konno, S. (2009) Synergistic Potentiation of D-Fraction with Vitamin C as Possible Alternative Approach for Cancer Therapy. International Journal of General Medicine, 2, 91-108. https://doi.org/10.2147/IJGM.S5498
|
[148]
|
Masuda, Y., Inoue, H., Ohta, H., et al. (2013) Oral Administration of Soluble B-Glucans Extracted from Grifola Frondosa Induces Systemic Antitumor Immune Response and Decreases Immunosuppression in Tumor-Bearing Mice. International Journal of Cancer, 133, 108-120. https://doi.org/10.1002/ijc.27999
|
[149]
|
Shomori, K., Yamamoto, M., Arifuku, I., Teramachi, K. and Ito, H. (2009) Antitumor Effects of a Water-Soluble Extract from Maitake (Grifola frondosa) on Human Gastric Cancer Cell Lines. Oncology Reports, 22, 615-620. https://doi.org/10.3892/or_00000480
|
[150]
|
Masuda, Y., Murata, Y., Hayashi, M. and Nanba, H. (2008) Inhibitory Effect of Mdfraction on Tumor Metastasis: Involvement of NK Cell activation and Suppression of Intercellular Adhesion Molecule (ICAM)-1 Expression in Lung Vascular Endothelial Cells. Biological and Pharmaceutical Bulletin, 31, 1104-1108. https://doi.org/10.1248/bpb.31.1104
|
[151]
|
Masuda, Y., Nakayama, Y., Tanaka, A., Naito, K. and Konishi, M. (2017) Antitumor Activity of Orally Administered Maitake Α-Glucan by Stimulating Antitumor Immune Response in Murine Tumor. PLOS ONE, 12, e0173621. https://doi.org/10.1371/journal.pone.0173621
|
[152]
|
Zhao, F., Zhao, J., Song, L., Zhang, Y.Q., Guo, Z. and Yang, K.H. (2017) The Induction of Apoptosis and Autophagy in Human Hepatoma SMMC-7721 Cells by Combined Treatment with Vitamin C and Polysaccharides Extracted from Grifola Frondosa. Apoptosis, 22, 1461-1472. https://doi.org/10.1007/s10495-017-1421-z
|
[153]
|
Lin, H., She Y.-H., Cassileth, B.R. et al. (2004) Maitake Beta-Glucan MD-Fraction Enhances Bone Marrow Colony Formation and Reduces Doxorubicin Toxicity in Vitro. International Immunopharmacology, 4, 91-99. https://doi.org/10.1016/j.intimp.2003.10.012
|
[154]
|
Dai, X., Stanilka, J.M., Rowe, C.A., Esteves, E.A., et al. (2015) Consuming Lentinula Edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. Journal of the American College of Nutrition, 34, 478-487. https://doi.org/10.1080/07315724.2014.950391
|
[155]
|
Ina, K., Furuta, R., Kataoka, T., et al. (2016) Chemo-Immunotherapy Using Lentinan for the Treatment of Gastrick Cancer with Liver Metastases. Medical Sciences, 4, Article 8. https://doi.org/10.3390/medsci4020008
|
[156]
|
Rincão, V.P., Yamamoto, K.A., Ricardo, N.M., et al. (2012) Polysaccharide and Extracts from Lentinula Edodes: Structural Features and Antiviral Activity. Virology Journal, 9, Article No. 37. https://doi.org/10.1186/1743-422X-9-37
|
[157]
|
Kim, S.P., Park, S.O., Lee, S.J., Nam, S.H. and Friedman, M. (2014) A Polysaccharide Isolated from the Liquid Culture of Lentinus Edodes (Shiitake) Mushroom Mycelia Containing Black Rice Bran Protects Mice against Salmonellosis through Upregulation of the Th1 Immune Reaction. Journal of Agricultural and Food Chemistry, 62, 2384-2391. https://doi.org/10.1021/jf405223q
|
[158]
|
Tanigawa, K., Itoh, Y. and Kobayashi, Y. (2016) Improvement of QOL and Immunological Function with Lentinula Edodes Mycelia in Patients Undergoing Cancer Immunotherapy: An Open Pilot Study. Alternative Therapies in Health and Medicine, 22, 36-42.
|
[159]
|
Jin, X., Ruiz, B.J., Sze, D.M.Y. and Chan, G.C.F. (2016) Ganoderma Lucidum (Reishi Mushroom) for Cancer Treatment (Review). Cochrane Database of Systematic Reviews, No. 4, CD007731. https://doi.org/10.1002/14651858.CD007731.pub3
|
[160]
|
Wang, C., Shi, S., Chen, Q., et al. (2018) Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats. Integrative Cancer Therapies, 17, 674-683. https://doi.org/10.1177/1534735418762537
|
[161]
|
Gill, S.K. and Rieder, M.J. (2008) Toxicity of a Traditional Chinese Medicine, Ganoderma lucidum, in Children with Cancer. Canadian Journal of Clinical Pharmacology, 15, e275-e285.
|
[162]
|
Yuen, M.F., Ip, P., Ng, W.K. and Lai, C.L. (2004) Hepatotoxicity Due to a Formulation of Ganoderma lucidum (Lingzhi). Journal of Hepatology, 41, 686-687. https://doi.org/10.1016/j.jhep.2004.06.016
|
[163]
|
Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W. and Bunyaratvej, S. (2007) Fatal Fulminant Hepatitis Associated with Ganoderma lucidum (Lingzhi) Mushroom Powder. Journal of the Medical Association of Thailand, 90, 179-181.
|
[164]
|
Bhushan, A. and Kulshreshtha, M. (2018) The Medicinal Mushroom Agaricus Bisporus: Review of Phytopharmacology and Potential Role in the Treatment of Various Diseases. Journal of Nature and Science of Medicine, 1, 4-9.
|
[165]
|
Vetter, J. (2003) Chemical Composition of Fresh Conserved Agaricus bisporus Mushroom. European Food Research and Technology, 217, 10-12. https://doi.org/10.1007/s00217-003-0707-2
|
[166]
|
Firenzuoli, F., Gori, L. and Lombardo, G. (2007) The Medicinal Mushroom Agaricus Blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. eCAM, 5, 3-15. https://doi.org/10.1093/ecam/nem007
|
[167]
|
Piska, K., Muszynska, B. and Ziaja, K. (2017) Edible Mushroom Pleurotus ostreatus (Oyster Mushroom)—Its Dietary Significance and Biological Activity. Acta Scientiarum Polonorum Hortorum Cultus, 16, 151-161.
|
[168]
|
Blagodatski, A., Yatsunskaya, M., Mikhailova, V., et al. (2018) Medicinal Mushrooms as an Attractive New Source of Natural Compounds for Future Cancer Therapy. Oncotarget, 9, 29259-29274. https://doi.org/10.18632/oncotarget.25660
|
[169]
|
Xu, T., Beelman, R.B. and Lambert, J.D. (2012) The Cancer Preventive Effects of Edible Mushrooms. Anti-Cancer Agents in Medicinal Chemistry, 12, 1255-1263. https://doi.org/10.2174/187152012803833017
|
[170]
|
Horneber, M.A., Bueschel, G., Huber, R., et al. (2008) Mistletoe Therapy in Oncology. Cochrane Database of Systematic Reviews, No. 2, CD003297. https://doi.org/10.1002/14651858.CD002833.pub2
|
[171]
|
Ostermann, T., Raak, C. and Bussing, A. (2009) Survival of Cancer Patients Treated With Mistletoe Extract (Iscador): A Systematic Literature Review. BMC Cancer, 9, Article No. 451. https://doi.org/10.1186/1471-2407-9-451
|
[172]
|
Melzer, J., Iten, F., Hostanska, K., et al. (2009) Efficacy and Safety of Mistletoe Preparations (Viscum album) for Patients with Cancer Diseases. A Systematic Review. Forschende Komplementärmedizin, 16, 217-226. https://doi.org/10.1159/000226249
|
[173]
|
Kleijnen, J. and Knipschild, P. (1994) Mistletoe Treatment for Cancer Review of Controlled Trials in Humans. Phytomedicine, 1, 255-260. https://doi.org/10.1016/S0944-7113(11)80073-5
|
[174]
|
Lyu, S.Y. and Park, W.B. (2007) Effects of Korean Mistletoe Lectin (Viscum album Coloratum) on Proliferation and Cytokine Expression in Human Peripheral Blood Mononuclear Cells and T-Lymphocytes. Archives of Pharmacal Research, 30, 1252-1264. https://doi.org/10.1007/BF02980266
|
[175]
|
Witters, L.A. (2001) The Blooming of the French Lilac. The Journal of Clinical Investigation, 108, 1105-1107. https://doi.org/10.1172/JCI14178
|
[176]
|
Werner, E. and Bell, J. (1922). The Preparation of Methylguanidine, and of Ββ-Dimethylguanidine by the Interaction of Dicyandiamide, and Methylammonium and Dimethylammonium Chlorides Respectively. Journal of the Chemical Society, Transactions, 121, 1790-1795. https://doi.org/10.1039/CT9222101790
|
[177]
|
Zi, F., Zi, H., Li, Y., et al. (2018) Metformin and Cancer: An Existing Drug for Cancer Prevention and Therapy (Review). Oncology Letters, 15, 683-690. https://doi.org/10.3892/ol.2017.7412
|
[178]
|
Gonzalez-Aungulo, A.M. and Meric-Bernstam, F. (2010) Metformin: A Therapeutic Opportunity in Breast Cancer. Clinical Cancer Research, 16, 1695-1700. https://doi.org/10.1158/1078-0432.CCR-09-1805
|
[179]
|
Li, C., Xue, Y., Xi, Y.R. and Xie, K. (2017) Progress in the Application and Mechanism of Metformin in Treating Non-Small Cell Lung Cancer (Review). Oncology Letters, 13, 2873-2880. https://doi.org/10.3892/ol.2017.5862
|
[180]
|
Rosilio, C., Ben-Sahra, I., Bost, F. and Peyron, J.F. (2014) Metformin: A Metabolic Disruptor and Anti-Diabetic Drug to Target Human Leukemia. Cancer Letters, 246, 188-196. https://doi.org/10.1016/j.canlet.2014.01.006
|
[181]
|
Andrzejewski, S., Gravel, S.P., Pollak, M. and St-Pierre, J. (2014) Metformin Directly Acts on Mitochondria to Alter Cellular Bioenergetics. Cancer and Metabolism, 2, Article No. 12. https://doi.org/10.1186/2049-3002-2-12
|
[182]
|
Devasagayam, T.P., Tilak, J.C., Boloor, K.K., Sane, K.S., Ghaskadbi, S.S. and Lele, R.D. (2004) Free Radicals and Antioxidants in Human Health: Current Status and Future Prospects. The Journal of the Association of Physicians of India, 52, 794-804.
|
[183]
|
Sing, K., Bhori, M., Kasu, Y.A., et al. (2018) Antioxidants as Precision Weapons in War against Cancer Chemotherapy Induced Toxicity—Exploring the Armoury of Obscurity. Saudy Pharmaceutical Journal, 26, 177-190. https://doi.org/10.1016/j.jsps.2017.12.013
|
[184]
|
Masri, O.A., Chalhoub, J.M. and Sharara, A.I. (2015) Role of Vitamins in Gastrointestinal Diseases. World Journal of Gastroenterology, 21, 5191-5209. https://doi.org/10.3748/wjg.v21.i17.5191
|
[185]
|
Funk, C. (1912) The Etiology of the Deficiency Diseases. Journal of State Medicine, 20, 341-368.
|
[186]
|
Piro, A., Tagarelli, G., Lagonia, P., et al. (2010) Casimir Funk: His Discovery of the Vitamins and Their Deficiency Disorders. Annals of Nutrition and Metabolism, 57, 85-88. https://doi.org/10.1159/000319165
|
[187]
|
Thyagarajan, A. and Sahu, R.P. (2018) Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization. Integrative Cancer Therapies, 17, 210-216. https://doi.org/10.1177/1534735416681639
|
[188]
|
Antioxidants: In Depth. https://nccih.nih.gov/health/antioxidants/introduction.htm
|
[189]
|
SzentGyörgyi, A. (1937) Oxidation, Energy Transfer, and Vitamins. Nobel Lecture.
|
[190]
|
Stahelin, H.B. (1988) Vitamins and Cancer, Recent Results. In: Senn, H.J., Glaus, A. and Schmid, L., Eds., Supportive Care in Cancer Patients. Recent Results in Cancer Research, Vol. 108, Springer-Verlag, Berlin, 227-234. https://doi.org/10.1007/978-3-642-82932-1_28
|
[191]
|
Cameron, E., Pauling, L. (1974) The Orthomolecular Treatment of Cancer. I. The Role of Ascorbic Acid in Host Resistance. Chemico-Biological Interactions, 9, 273-283. https://doi.org/10.1016/0009-2797(74)90018-0
|
[192]
|
Cameron, E. and Pauling, L. (1976) Supplemental Ascorbate in the Supportive Treatment of Cancer: Prolongation of Survival Times in Terminal Human Cancer. Proceedings of the National Academy of Sciences of the United States of America, 73, 3685-3689. https://doi.org/10.1073/pnas.73.10.3685
|
[193]
|
Cameron, E. and Campbell, A. (1991) Innovation vs. Quality Control: An “Unpublishable” Clinical Trial of Supplemental Ascorbate in Incurable Cancer. Medical Hypotheses, 36, 185-189. https://doi.org/10.1016/0306-9877(91)90127-K
|
[194]
|
Cameron, E. and Pauling, L. (1978) Supplemental Ascorbate in the Supportive Treatment of Cancer: Reevaluation of Prolongation of Survival Times in Terminal Human Cancer. Proceedings of the National Academy of Sciences of the United States of America, 75, 4538-4542. https://doi.org/10.1073/pnas.75.9.4538
|
[195]
|
Creagan, E.T., Moertel, C.G., O’Fallon, J.R., et al. (1979) Failure of High-Dose Vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer. A Controlled Trial. New England Journal of Medicine, 301, 687-690. https://doi.org/10.1056/NEJM197909273011303
|
[196]
|
Tschetter, L., et al. (1983) A Community-Based Study of Vitamin C (Ascorbic Acid) in Patients with Advanced Cancer. Proceedings of the American Society of Clinical Oncology, 2, Article No. 92.
|
[197]
|
Shenoy, N., Creagan, E., Witzig, T. and Levine, M. (2018) Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly. Cancer Cell, 34, 700-706. https://doi.org/10.1016/j.ccell.2018.07.014
|
[198]
|
Reczek, C.R. and Chandel, N.S. (2015) Revisiting Vitamin C and Cancer. Science, 350, 1317-1318. https://doi.org/10.1126/science.aad8671
|
[199]
|
Hoffer, L.J., Levine, M., Assouline, S., et al. (2008) Phase I Clinical Trial of I.V. Ascorbic Acid in Advanced Malignancy. Annals of Oncology, 19, 1969-1974. https://doi.org/10.1093/annonc/mdn377
|
[200]
|
Stephenson, C.M., Levin, R.D., Spector, T., et al. (2013) Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of High-Dose Intravenous Ascorbic Acid in Patients with Advanced Cancer. Cancer Chemotherapy and Pharmacology, 72, 139-146. https://doi.org/10.1007/s00280-013-2179-9
|
[201]
|
Riordan, H.D., Casciari, J.J., Gonzalez, M.J., et al. (2005) A Pilot Clinical Study of Continuous Intravenous Ascorbate in Terminal Cancer Patients. Puerto Rico Health Sciences Journal, 24, 269-276.
|
[202]
|
Carr, A.C., Vissers, M.C.M. and Cook, J. (2014) Relief from Cancer Chemotherapy Side Effects with Pharmacologic Vitamin C. New Zealand Medical Journal, 127, 66-70.
|
[203]
|
Ma, Y., Chapman, J., Levine, M., Polireddy, K., Drisko, J. and Chen, Q. (2014) High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy. Science Translational Medicine, 6, 222-218. https://doi.org/10.1126/scitranslmed.3007154
|
[204]
|
Monti, D.A., Mitchell, E., Bazzan, A.J., Littman, S., Zabrecky, G., Yeo, C.J., Pillai, M.V., Newberg, A.B., Deshmukh, S. and Levine, M. (2012) Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer. PLOS ONE, 7, e29794. https://doi.org/10.1371/journal.pone.0029794
|
[205]
|
Welsh, J.L., Wagner, B.A., van’t Erve, T.J., et al. (2013) Pharmacological Ascorbate with Gemcitabine for the Control of Metastatic and Node-Positive Pancreatic Cancer (PACMAN): Results from a Phase I Clinical Trial. Cancer Chemotherapy and Pharmacology, 71, 765-775. https://doi.org/10.1007/s00280-013-2070-8
|
[206]
|
Ou, J., Zhu, X., Lu, Y., et al. (2017) The Safety and Pharmacokinetics of High Dose Intravenous Ascorbic Acid Synergy with Modulated Electrohyperthermia in Chinese Patients with Stage III-IV Non-Small Cell Lung Cancer. European Journal of Pharmaceutical Sciences, 109, 412-418. https://doi.org/10.1016/j.ejps.2017.08.011
|
[207]
|
Carr, A.C., Vissers, M.C.M. and Cook, J. (2014) The Effect of Intravenous Vitamin C on Cancer—And Chemotherapy-Related Fatigue and Quality of Life. Frontiers in Oncology, 4, Article No. 283. https://doi.org/10.3389/fonc.2014.00283
|
[208]
|
Vollbracht, C., Schneider, B., Leendert, V., Weiss, G., Auerbach, L. and Beuth, J. (2011) Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre. Epidemiological Cohort Study in Germany, in Vivo, 25, 983-990.
|
[209]
|
Da Mata, A.M.O.F., De Carvalho, R.M., De Alencar, M.V.O.B., Cavalcante, A.M.D.C.M. and Da Silva, B.B. (2016) Ascorbic Acid in the Prevention and Treatment of Cancer. Revista da Associação Médica Brasileira, 62, 680-686. https://doi.org/10.1590/1806-9282.62.07.680
|
[210]
|
Mikirova, N., Casciari, J., Rogers, A. and Taylor, P. (2012) Effect of High-Dose Intravenous Vitamin C on Inflammation in Cancer Patients. Journal of Translational Medicine, 10, Article No. 189. https://doi.org/10.1186/1479-5876-10-189
|
[211]
|
Barrett, S. (2011, October 3) High Doses of Vitamin C Are Not Effective as a Cancer Treatment. https://www.quackwatch.org/01QuackeryRelatedTopics/Cancer/c.html
|
[212]
|
Vissers, M.C.M. and Das, A.B. (2018) Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence. Frontiers in Physiology, 9, Article No. 809. https://doi.org/10.3389/fphys.2018.00809
|
[213]
|
Bast, A. and Haenen, G.R.M.M. (2013) Ten Misconceptions about Antioxidants. Trends in Pharmacological Sciences, 34, 430-436. https://doi.org/10.1016/j.tips.2013.05.010
|
[214]
|
Podmore, I.D., Griffiths, H.R., Herbert, K.E., et al. (1998) Vitamin C Exhibits Pro-Oxidant Properties. Nature, 392, Article No.559. https://doi.org/10.1038/33308
|
[215]
|
Myung, S.K. and Yang, H.J. (2013) Efficacy of Vitamin and Antioxidant Supplements in Prevention of Esophageal Cancer: Meta-Analysis of Randomized Controlled Trials. Journal of Cancer Prevention, 18, 135-143. https://doi.org/10.15430/JCP.2013.18.2.135
|
[216]
|
Jain, A., Tiwari, A., Verma, A., et al. (2017) Vitamins for Cancer Prevention and Treatment: An Insight. Current Molecular Medicine, 17, 321-340. https://doi.org/10.2174/1566524018666171205113329
|
[217]
|
Mut-Salud, N., álvarez, P.J., Garrido, J.M., et al. (2016) Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results. Oxidative Medicine and Cellular Longevity, 2016, Article ID: 6719534. https://doi.org/10.1155/2016/6719534
|
[218]
|
Watson, J. (2013) Oxidants, Antioxidants and the Current Incurability of Metastatic Cancers. Open Biology, 3, Article ID: 120144. https://doi.org/10.1098/rsob.120144
|
[219]
|
(2013) James Watson Hypothesis Links Cancer to Antioxidants. https://www.genengnews.com/topics/omics/james-watson-hypothesis-links-cancer-to-antioxidants
|
[220]
|
Meffert, H. (2008) Antioxidants—Friend or Foe? GMS German Medical Science, 6, Doc09. https://www.egms.de/static/en/journals/gms/2008-6/000054.shtml
|
[221]
|
Bjelakovic, G., Nikolova, D., et al. (2007) Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-Analysis. JAMA, 297, 842-857. https://doi.org/10.1001/jama.297.8.842
|
[222]
|
Bjelakovic, G., Nikolova, D., Gluud, L.L., et al. (2007) Review: Antioxidant Supplements for Primary and Secondary Prevention Do Not Decrease Mortality. JAMA, 297, 842-857. https://doi.org/10.1001/jama.297.8.842
|
[223]
|
Bjelakovic, G., Nikolova, D. and Gluud, C. (2013) Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm? PLOS ONE, 8, e74558. https://doi.org/10.1371/journal.pone.0074558
|
[224]
|
Bjelakovic, G., Nikolova, D. and Simonetti, R.G. (2008) Systematic Review—Primary and Secondary Prevention of Gastrointestinal Cancers with Antioxidant Supplements. Alimentary Pharmacology & Therapeutics, 28, 689-703. https://doi.org/10.1111/j.1365-2036.2008.03785.x
|
[225]
|
Dotan, Y., Pinchuk, I., Lichtenberg, D., et al. (2009) Decision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than Good. Arteriosclerosis, Thrombosis, and Vascular Biology, 29, 1304-1309. https://doi.org/10.1161/ATVBAHA.108.178699
|
[226]
|
Akanji, M.A., Fatinukun, H.D. and Rotini, D.E. (2020) The Two Sides of Dietary Antioxidants in Cancer Therapy. InTech Open, 1-16. https://www.intechopen.com/chapters/66504
|
[227]
|
Acharya, A., Das, I., Chandhok, D. and Saha, T. (2010) Redox Regulation in Cancer: A Double-Edged Sword with Therapeutic Potential. Oxidative Medicine and Cellular Longevity, 3, 23-34. https://doi.org/10.4161/oxim.3.1.10095
|
[228]
|
Aasdi-Samani, M., Farkhad, N.K., Mahmoudian-Sani, M.R., et al. (2019) Antioxidants as a Double-Edged Sword in the Treatment of Cancer. In: Shalaby, E., Ed., Antioxidants, IntechOpen, London. https://www.intechopen.com/chapters/66504
|
[229]
|
Conklin, K.A. (2004) Cancer Chemotherapy and Antioxidants. The Journal of Nutrition, 134, 3201S-3204S. https://doi.org/10.1093/jn/134.11.3201S
|
[230]
|
Sznarkowska, A., Kostecka, A., Meller, K. and Bielawski, K.P. (2017) Inhibition of Cancer Antioxidant Defense by Natural Compounds. Oncotarget, 8, 15996-16016. https://doi.org/10.18632/oncotarget.13723
|
[231]
|
Szasz, O., Szigeti, G.P. and Szasz, A. (2017) On the Self-Similarity in Biologyical Processes. OJBIPHY, 7, 183-196. https://doi.org/10.4236/ojbiphy.2017.74014
|
[232]
|
Szasz, O., Szigeti, G.P. and Szasz, A. (2019) The Intrinsic Self-Time of Biosystems. OJBIPHY, 9, 131-145.
|
[233]
|
Kovacic, P. and Osuna, J.A. (2000) Mechanisms of Anti-Cancer Agents: Emphasis on Oxidative Stress and Electron Transfer. Current Pharmaceutical Design, 6, 277-309. https://doi.org/10.2174/1381612003401046
|
[234]
|
Mamede, A.C., Tavares, S.D., Abrantes, A.M., et al. (2011) Role of Vitamins in Cancer: A Review. Nutrition and Cancer, 63, 479-494. https://doi.org/10.1080/01635581.2011.539315
|
[235]
|
Teitelbaum, H.A. (1956) Homeostasis and Personality. Archives of Neurology & Psychiatry, 76, 317-324. https://doi.org/10.1001/archneurpsyc.1956.02330270089016
|
[236]
|
Stagner, R. (1951) Homeostasis as a Unifying Concept in Personality Theory. Psychological Review, 58, 5-17. https://doi.org/10.1037/h0063598
|
[237]
|
Cummins, R.A., Gullone, E. and Lau, A.L.D. (2002) A Model of Subjective Well-Being Homeostasis: The Role of Personality. In: Gullone, E. and Cummins, R.A., Eds., The Universality of Subjective Wellbeing Indicators, Social Indicators Research Series, Vol. 16, Springer, Dordrecht, 7-46. https://doi.org/10.1007/978-94-010-0271-4
|
[238]
|
Dicks, L.M.T., Geldenhuys, J., Mikkelsen, L.S., et al. (2018) Our Gut Microbiota: A Long Walk to Homeostasis. Benef Microbes, 9, 3-20. https://doi.org/10.3920/BM2017.0066
|
[239]
|
Pédron, T., Nigro, G. and Sansonetti, P.J. (2016) From Homeostasis to Pathology: Decrypting Microbe-Host Symbiotic Signals in the Intestinal Crypt. Philosophical Transactions of the Royal Society B, 371, Article ID: 20150500. https://doi.org/10.1098/rstb.2015.0500
|
[240]
|
Armour, C.R., Nayfach, S., Pollard, K.S. and Sharpton, T.J. (2019) A Metagenomic Meta-Analysis Reveals Functional Signatures of Health and Disease in the Human Gut Microbiome. mSystems, 4, e00332-18. https://doi.org/10.1128/mSystems.00332-18
|
[241]
|
Huybrechts, I., Zouiouich, S., Loobuyck, A., et al. (2020) The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies. Cancer Epidemiology, Biomarkers & Prevention, 10, 1856-1868. https://doi.org/10.1158/1055-9965.EPI-20-0288
|
[242]
|
Gethings-Behncke, C., Coleman, H.G., Jordao, H.W.T., et al. (2020) Fusobacterium nucleatum in the Colorectum and Its Association with Cancer Risk and Survival: A Systematic Review and Meta-Analysis. Cancer Epidemiology, Biomarkers & Prevention, 3, 539-548. https://doi.org/10.1158/1055-9965.EPI-18-1295
|
[243]
|
Brusselaers, N., Shrestha, S., van de Wijgert, J. and Verstraelen, H. (2019) Vaginal Dysbiosis and the Risk of Human Papillomavirus and Cervical Cancer: Systematic Review and Meta-Analysis. American Journal of Obstetrics and Gynecology, 221, 9-18.e8. https://doi.org/10.1016/j.ajog.2018.12.011
|
[244]
|
Yang, J.J., Yu, D., Xiang, Y.B., et al. (2020) Association of Dietary Fiber and Yogurt Consumption with Lung Cancer Risk: A Pooled Analysis. JAMA Oncology, 6, e194107. https://doi.org/10.1001/jamaoncol.2019.4107
|
[245]
|
Perrone, A.M., Pirovano, C., Borghese, G., et al. (2019) Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study. Cancers, 11, 657. https://doi.org/10.3390/cancers11050657
|
[246]
|
Mazzocca, A. (2019) The Systemic-Evolutionary Theory of the Origin of Cancer (SETOC): A New Interpretative Model of Cancer as a Complex Biological System. International Journal of Molecular Sciences, 20, Article 4885. https://doi.org/10.3390/ijms20194885
|
[247]
|
Sharma, V. (2016) The Application of Chaos Theory and Fractal Mathematics to the Study of Cancer Evolution: Placing Metabolism and Immunity Centre Stage. Medical Research Archives, 4, 1-12. https://doi.org/10.18103/mra.v4i6.717
|
[248]
|
Balmain, A., Gray, J. and Ponder, B. (2014) The Genetics and Genomics of Cancer. Nature Genetics, 33, 238-244. https://doi.org/10.1038/ng1107
|
[249]
|
Szigeti, G.P., Szasz, O. and Hegyi, G. (2017) Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer. Journal of Neoplasm, 1, Article No. 8. http://neoplasm.imedpub.com/connections-between-warburgs-and-szentgyorgyis-approach-about-thecauses-of-cancer.pdf
|
[250]
|
Hanahan, D. and Weinberg, R.A. (2000) The Hallmarks of Cancer. Cell, 100, 57-70. https://doi.org/10.1016/S0092-8674(00)81683-9
|
[251]
|
Dyas, F.G. (1928) Chronic Irritation as a Cause of Cancer. JAMA, 90, 457. https://doi.org/10.1001/jama.1928.92690330003008c
|
[252]
|
Dvorak, H.F. (1986) Tumors: Wounds that Do Not Heal, Similarities between Tumor Stroma Generation and Wound Healing. The New England Journal of Medicine, 315, 1650-1659. https://doi.org/10.1056/NEJM198612253152606
|
[253]
|
Platz, E.A. and De Marzo, A.M. (2004) Epidemiology of Inflammation and Prostate Cancer. The Journal of Urology, 171, S36-S40. https://doi.org/10.1097/01.ju.0000108131.43160.77
|
[254]
|
Hanahan, D. and Weinberg, R.A. (2011) Hallmarks of Cancer: The Next Generation. Cell, 144, 646-674. https://doi.org/10.1016/j.cell.2011.02.013
|
[255]
|
Punyiczki, M. and Fesus, L. (1998) Heat Shock and Apoptosis: The Two Defense Systems of the Organisms May Have Overlapping Molecular Elements. Annals of the New York Academy of Sciences, 951, 67-74. https://doi.org/10.1111/j.1749-6632.1998.tb08978.x
|
[256]
|
Popkin, G. (2011) Physics Sheds Light on Cancer and Bacteria Evolution. APC News, Vol. 20, No. 5. https://www.aps.org/publications/apsnews/201105/cancerbacteria.cfm
|
[257]
|
Trigos, A.S., Pearson, R.B., Paenfuss, A.T., et al. (2018) How the Evolution of Multicellularity Set the Stage for Cancer. British Journal of Cancer, 118, 145-152. https://doi.org/10.1038/bjc.2017.398
|
[258]
|
Trigos, A.S., Pearson, R.B., Papenfuss, A.T., et al. (2016) Altered Interactions between Unicellular and Multicellular Genes Drive Hallmarks of Transformation in a Diverse Range of Solid Tumors. PNAS, 114, 6406-6411. https://doi.org/10.1073/pnas.1617743114
|
[259]
|
Aktipis, C.A., Bobby, A.M., Jansen, G., et al. (2015) Cancer across the Tree of Life: Cooperation and Cheating in Multicellularity. Philosophical Transactions of the Royal Society B, 370, Article ID: 20140219. https://doi.org/10.1098/rstb.2014.0219
|
[260]
|
Davidson, C.D., Wang, W.Y., Zaimi, I., et al. (2019) Cell Force-Mediated Matrix Reorganization Underlies Multicellular Network Assembly. Scientific Reports, 9, Article No. 12. https://doi.org/10.1038/s41598-018-37044-1
|
[261]
|
Jezequel, P. and Campone, M. (2018) Comment on “How the Evolution of Multicellularity Set the Stage for Cancer”. British Journal of Cancer, 119, 133-134. https://doi.org/10.1038/s41416-018-0091-0
|
[262]
|
Szentgyorgyi, A. (1998) Electronic Biology and Cancer. Marcel Dekker, New York.
|
[263]
|
Kirson, E.D., Gurvich, Z., Schneiderman, R., et al. (2004) Disruption of Cancer Cell Replication by Alternating Electric Fields. Cancer Research, 64, 3288-3295. https://doi.org/10.1158/0008-5472.CAN-04-0083
|
[264]
|
Vincze, G., Sziget, G.P. and Szasz, A. (2016) Reorganization of the Cytoskeleton. Journal of Advances in Biology, 9, 1872-1882. https://cirworld.com/index.php/jab/article/view/4059
|
[265]
|
Springer, M. and Paulsson, J. (2006) Harmonies from Noise. Nature, 439, 27-28. https://doi.org/10.1038/439027a
|
[266]
|
West, J.B. (2013) Fractal Physiology and Chaos in Medicine. World Scientific, Singapore. https://doi.org/10.1142/8577
|
[267]
|
Szasz, O., Vincze, G., Szigeti, G.P. and Szasz, A. (2017) Intrinsic Noise Monitoring of Complex Systems. OJBIPHY, 7, 197-215. https://doi.org/10.4236/ojbiphy.2017.74015
|
[268]
|
Friedman, E., Verderame, M., Winawer, S. and Pollack, R. (1984) Actin Cytoskeletal Organization Loss in the Benign-to-Malignant Tumor Transition in Cultured Human Colonic Epithelial Cells. Cancer Research, 44, 3040-3050.
|
[269]
|
Suresh, S. (2007) Biomechanics and Biophysics of Cancer Cells. Acta Biomaterialia, 3, 413-438. https://doi.org/10.1016/j.actbio.2007.04.002
|
[270]
|
Plodinec, M., Loparic, M., Monnier, C.A., et al. (2012) The Nanomechanical Signature of Breast Cancer. Nature Nanotechnology, 7, 757-765. http://www.nature.com/nnano/journal/v7/n11/full/nnano.2012.167.html?WT.ec_id=NNANO-201211
|
[271]
|
Wirts, D., Konstantopoulos, K. and Searson, P.C. (2011) The Physics of Cancer: The Role of Physical Interactions and Mechanical Forces in Metastasis. Nature Reviews, Cancer, 11, 512-518. https://doi.org/10.1038/nrc3080
|
[272]
|
Uklrich, T.A., Pardo, E.M.D.J. and Kumar, S. (2009) The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells. Cancer Research, 69, 4167-4175. https://doi.org/10.1158/0008-5472.CAN-08-4859
|
[273]
|
Hameroff, S.R. (1988) Coherence in the Cytoskeleton: Implications for Biological Information Processing. In: Froelich, H., Ed., Biological Coherence and Response to External Stimuli, Springer Verlag, Berlin, 242-266. https://doi.org/10.1007/978-3-642-73309-3_14
|
[274]
|
Janmey, P. (1995) Cell Membranes and the Cytoskeleton. In: Lipowsky, R. and Sackinan, E., Eds., Handbook of Biological Physics, Volume I, Elsevier Science, Amsterdam, 805-849. https://doi.org/10.1016/S1383-8121(06)80010-2
|
[275]
|
Del, Giudice, E., et al. (1988) Structures, Correlations and Electroimagnetic Interactions in Living Matter. In: Froelich, H., Ed., Biological Coherence and Response to External Stimuli, Springer Verlag, Berlin, 49-64. https://doi.org/10.1007/978-3-642-73309-3_3
|
[276]
|
Cho, M.R., Thatte, H.S., Lee, R.C., et al. (1996) Reorganization of Microfilament Structure Induced by Ac Electric Fields. FASEB Journal, 10, 1552-1558. https://doi.org/10.1096/fasebj.10.13.8940302
|
[277]
|
Agmon, N. (1995) The Grotthuss Mechanism. Chemical Physics Letters, 244, 456-462. https://doi.org/10.1016/0009-2614(95)00905-J
|
[278]
|
Markovitch, O. and Agmon, N. (2007) Structure and Energetics of the Hydronium Hhydration Shells. The Journal of Physical Chemistry A, 111, 2253-2256. https://doi.org/10.1021/jp068960g
|
[279]
|
Jackson, M.D.B., Duran-Nebreda, S. and Bassel, G.W. (2017) Network-Based Approaches to Quantify Multicellular Development. Journal of the Royal Society Interface, 14, Article ID: 20170484. https://doi.org/10.1098/rsif.2017.0484
|
[280]
|
Adami, C. (1995) Self-Organized Criticality in Living Systems. Physics Letters A, 203, 29-32. https://doi.org/10.1016/0375-9601(95)00372-A
|
[281]
|
Seo, H., Kim, W., Lee, J., et al. (2013) Network-Based Approaches for Anticancer Therapy (Review). International Journal of Oncology, 43, 1737-1744. https://doi.org/10.3892/ijo.2013.2114
|
[282]
|
Barabasi, A.L., Menichetti, G. and Loscalzo, J. (2019) The Unmapped Chemical Complexity of Our Diet. Nature Food, 1, 33-37. https://doi.org/10.1038/s43016-019-0005-1
|
[283]
|
Albert, R. (2005) Scale-Free Networks in Cell Biology. Journal of Cell Science, 118, 4947-4957. https://doi.org/10.1242/jcs.02714
|
[284]
|
Bak, P., Chen, K. and Creutz, M. (1989) Self-Organized Criticality in the “Game of Life”. Nature, 342, 780-782. https://doi.org/10.1038/342780a0
|
[285]
|
Bak, P., Tang, C. and Wiesenfeld, K. (1987) Self-Organized Criticality: An Explanation of 1/f Noise. Physical Review Letters, 59, 381-384. https://doi.org/10.1103/PhysRevLett.59.381
|
[286]
|
Szendro, P., Vincze, G. and Szasz, A. (2001) Pink Noise Behaviour of the Bio-Systems. European Biophysics Journal, 30, 227-231. http://www.ncbi.nlm.nih.gov/pubmed/11508842
|
[287]
|
Szendro, P., Vincze, G. and Szasz, A. (2001) Bio-Response to White Noise Excitation. Electro- and Magnetobiology, 20, 215-229. http://www.tandfonline.com/doi/abs/10.1081/JBC-100104145?journalCode=iebm19
|
[288]
|
Szasz, A. (2014) Oncothermia: Complex Therapy by EM and Fractal Physiology. 31th URSI General Assembly and Scientific Symposium (URSI GASS), Beijing, 16-23 August 2014, 1-4. https://ieeexplore.ieee.org/document/6930100
|
[289]
|
Szasz, A., Vincze, G., Szigeti, G. and Szasz, O. (2017) Internal Charge Redistribution and Currents in Cancerous Lesions. Journal of Advances in Biology, 10, 2061-2079.
|
[290]
|
Lineweaver, C.H., Davies, P.C.W. and Vincent, M.D. (2014) Targeting Cancer’s Weaknesses (Not Its Strengths): Therapeutic Strategies Suggested by the Atavistic Model. Bioessays, 36, 827-835. https://doi.org/10.1002/bies.201400070
|
[291]
|
Reid, B., McCaig, C.D., Zhao, M., et al. (2005) Wound Healing in Rat Cornea: The Role of Electric Currents. FASEB Journal, 19, 379-386. https://doi.org/10.1096/fj.04-2325com
|
[292]
|
Balkwill, F. and Mantovani, A. (2001) Inflammation and Cancer: Back to Virchow? The Lancet, 357, 539-545. https://doi.org/10.1016/S0140-6736(00)04046-0
|
[293]
|
Fiala, E.S., Sohn, O.S., Wang, C.X., et al. (2005) Induction of Preneoplastic Lung Lesions in Guinea Pigs by Cigarette Smoke Inhalation and their Exacerbation by High Dietary Levels of Vitamins C and E. Carcinogenesis, 26, 605-612. https://doi.org/10.1093/carcin/bgh341
|
[294]
|
Murthy, N.S. and Mathew, A. (2000) Risk Factors for Pre-Cancerous Lesions of the Cervix. European Journal of Cancer Prevention, 9, 5-14. https://doi.org/10.1097/00008469-200002000-00002
|
[295]
|
Molloy, R.M. and Sonnenberg, A. (1997) Relation between Gastric Cancer and Previous Peptic Ulcer Disease. Gut, 40, 247-252. https://doi.org/10.1136/gut.40.2.247
|
[296]
|
Sundaram, G.M., Quah, S. and Sampath, P. (2018) Cancer: The Dark Side of Wound Healing. The FEBS Journal, 285, 4516-4534. https://doi.org/10.1111/febs.14586
|
[297]
|
Schafer, M. and Werner, S. (2008) Cancer as an Overhealing Wound: An Old Hypothesis Revisited. Nature Reviews Molecular Cell Biology, 9, 628-638. https://doi.org/10.1038/nrm2455
|
[298]
|
Dvorak, H.F. (2015) Tumors: Wounds That Do Not Heal—Redux. Cancer Immunology Research, 3, 1-11. https://doi.org/10.1158/2326-6066.CIR-14-0209
|
[299]
|
Feng, Y., Santoriello, C., Mione, M., Hurlstone, A. and Martin, P. (2010) Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLOS Biology, 8, e1000562. https://doi.org/10.1371/journal.pbio.1000562
|
[300]
|
Gionzalez, H., Hagerling, C. and Werb, Z. (2018) Roles of the Immune System in Cancer: From Tumor Initiation to Metastatic Progression. Genes and Development, 32, 1267-1284. https://doi.org/10.1101/gad.314617.118
|
[301]
|
Jia, W., Li, H., Zhao, L., et al. (2008) Gut Microbiota: A Potential New Territory for Drug Targeting. Nature Reviews, 7, 123-129. https://doi.org/10.1038/nrd2505
|
[302]
|
Hanausek, M., Walaszek, Z. and Slaga, T.J. (2003) Detoxifying Cancer Causing Agents to Prevent Cancer. Integrative Cancer Therapies, 2, 139-144. https://doi.org/10.1177/1534735403002002005
|
[303]
|
Shankaran, V., Ikeda, H., Bruce, A.T., White, J.M., Swanson, P.E., Old, L.J. and Schreiber, R.D. (2001) IFNgamma and Lymphocytes Prevent Primary Tumour Development and Shape Tumour Immunogenicity. Nature, 410, 1107-1111. https://doi.org/10.1038/35074122
|
[304]
|
Shankaran, V., Ikeda, H., Bruce, A.T., et al. (2018) Pillars Article: IFNgamma and Lymphocytes Prevent Primary Tumour Development and Shape Tumor Immunogenicity. The Journal of Immunology, 201, 827-831.
|
[305]
|
Dunn, G.P., Old, L.J. and Schreiber, R.D. (2004) The Immunobiology of Cancer Immunosurveillance and Immunoediting. Immunity, 21, 137-148. https://doi.org/10.1016/j.immuni.2004.07.017
|
[306]
|
Dunn, G.P., Koebel, C.M. and Schreiber, R.D. (2006) Interferons, Immunity and Cancer Immunoediting. Nature Reviews Immunology, 6, 836-848. https://doi.org/10.1038/nri1961
|
[307]
|
Miller, J.S. (2001) The Biology of Natural Killer Cells in Cancer, Infection, and Pregnancy. Experimental Hematology, 29, 1157-1168. https://doi.org/10.1016/S0301-472X(01)00696-8
|
[308]
|
Ghiringhelli, F., Menard, C., Martin, F. and Zitvogel, L. (2006) The Role of Regulatory T Cells in the Control of Natural Killer Cells: Relevance during Tumor Progression. Immunological Reviews, 214, 229-238. https://doi.org/10.1111/j.1600-065X.2006.00445.x
|
[309]
|
Honda, K. and Littman, D.R. (2016) The Microbiota in Adaptive Immune Homeostasis and Disease. Nature, 535, 75-84. https://doi.org/10.1038/nature18848
|
[310]
|
Belkaid, Y. and Harrison, O.J. (2017) Homeostatic Immunity and the Microbiota. Immunity, 46, 562-567. https://doi.org/10.1016/j.immuni.2017.04.008
|
[311]
|
Cholujova, D., Jakubikova, J. and Sedlak, J. (2009) Biobran-Augmented Maturation of Human Monocyte-Derived Dendritic Cells. Neoplasma, 56, 89-95. https://doi.org/10.4149/neo_2009_02_89
|
[312]
|
Romero, D. (2019) From New Directions in Immuno-Oncology. Nature Reviews Clinical Oncology, 16, 660. https://doi.org/10.1038/s41571-019-0280-7
|
[313]
|
Busch, W. (1868) Aus der Sitzung der medicinischen Section vom 13 November 1867. Berliner Klinische Wochenschrift, 5, 137.
|
[314]
|
Burnet, F.M. (1970) The Concept of Immunological Surveillance. Progress in Experimental Tumor Research, 13, 1-27. https://doi.org/10.1159/000386035
|
[315]
|
Akinleye, A. and Rasool, Z. (2019) Immune Checkpoint Inhibitors of PD-L1 as Cancer Therapeutics. Journal of Hematology & Oncology, 12, 92. https://doi.org/10.1186/s13045-019-0779-5
|
[316]
|
Bakacs, T., Mehrishi, J.N. and Moss, R.W. (2012) Ipilimumab (Yervoy) and the TGN1412 Catastrophe. Immunobiology, 217, 583-589. https://doi.org/10.1016/j.imbio.2011.07.005
|
[317]
|
Bakacs, T., Kristof, K., Mehrishi, J., et al. (2017) Autoimmune T-Cells Induced by Low Dose Immune Checkpoint Blockade Could Be a Powerful Therapeutic Tool in Cancer through Activation of Eliminative Inflammation and Immunity. Internal Medicine Review, 3, 1-8. https://doi.org/10.18103/imr.v3i4.408
|
[318]
|
Conklin, K.A. (2009) Dietary Antioxidants during Cancer Chemotherapy: Impact on Chemotherapeutic Effectiveness and Development of Side Effects. Nutrition and Cancer, 37, 1-18. https://doi.org/10.1207/S15327914NC3701_1
|
[319]
|
Tait, P., Morris, B. and To, T. (2014) Core Palliative Medicines-Meeting the Needs of Non-Complex Community Patients. Australian Family Physician, 43, 29-32.
|
[320]
|
International Association for Hospice and Palliative Care (IAHPC) (2013) World Health Organization (WHO) Essential Medicines in Palliative Care, Executive Summary. https://www.who.int/selection_medicines/committees/expert/19/applications/PalliativeCare_8_A_R.pdf
|
[321]
|
WA Cancer and Palliative Care Network, Essential Palliative Care Medication Lists for Community Pharmacists and General Practitioners, Government of Western Australia, Department of Health, 2011. https://ww2.health.wa.gov.au/~/media/Files/Corporate/general%20documents/Health%20Networks/WA%20Cancer%20and%20Palliative%20Care/Palliative%20care/Essential-Palliative-Care-Medication-Lists-for-Community-Pharmacists-and-General-Practitioners.pdf
|
[322]
|
Davies, A.M. Weinberg, U. and Palti, Y. (2013) Tumor Treating Fields: A New Frontier in Cancer Therapy. Annals of the New York Academy of Sciences, 1291, 86-95. https://doi.org/10.1111/nyas.12112
|
[323]
|
Chu, X.Y., Huang, W., Meng, L.W., et al. (2019) Improving Antitumor Outcomes for Palliative Intratumoral Injection Therapy through Lecithin-Chitosan Nanoparticles Loading Paclitaxel-Cholesterol Complex. International Journal of Nanomedicine, 14, 689-705. https://doi.org/10.2147/IJN.S188667
|
[324]
|
Liangruksa, M. (2011) Nanoscale Thermal Transport for Biological and Physical Applications. Dissertation, Virginia Polytechnic Institute and State University, Blacksburg.
|
[325]
|
Govorov, A.O. and Richardson, H.H. (2007) Generating Heat with Metal Nanoparticles. NanoToday, 2, 30-38. https://doi.org/10.1016/S1748-0132(07)70017-8
|
[326]
|
Gannon, C.J., Patra, C.R., Bhattacharya, R., et al. (2008) Intracellular Gold Nanoparticles Enhance Non-Invasive Radiofrequency Thermal Destruction of Human Gastrointestinal Cancer Cells. Journal of Nanobiotechnology, 6, 2. https://doi.org/10.1186/1477-3155-6-2
|
[327]
|
Szasz, A. (2015) Bioelectromagnetic Paradigm of Cancer Treatment Oncothermia. In: Rosch, P.J., Ed., Bioelectromagnetic and Subtle Energy Medicine, CRC Press, Taylor & Francis Group, Boca Raton, 323-336.
|
[328]
|
Raoof, M., Cisneros, B.T., Corr, S.J., et al. (2013) Tumor Selective Hyperthermia Induced by Short-Wave Capacitively-Coupled RF Electric-Fields. PLOS ONE, 8, e68506. https://doi.org/10.1371/journal.pone.0068506
|
[329]
|
Andocs, G., Rehman, M.U., Zhao, Q.L., Papp, E., Kondo, T. and Szasz, A. (2015) Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model. Biology and Medicine, 7, 1-9. https://doi.org/10.4172/0974-8369.1000247
|
[330]
|
Kirson, E.D., Dbaly, V., Tovarys, F., et al. (2007) Alternating Electric Fields Arrest Cell Proliferation, in Animal Tumor Models and Human Brain Tumors. Proceedings of the National Academy of Sciences of the United States of America, 104, 10152-10157. https://doi.org/10.1073/pnas.0702916104
|
[331]
|
Giladi, M., Munster, M., Schneiderman, R.S., et al. (2017) Tumor Treating Fields (Ttfields) Delay DNA Damage Repair Following Radiation Treatment of Glioma Cells. Radiation Oncology, 12, 206. https://doi.org/10.1186/s13014-017-0941-6
|
[332]
|
Stupp, R., Tailibert, S., Kanner, A., et al. (2017) Effect of Tumor-Treating Fields plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients with Glioblastoma: A Randomized Clinical Trial. JAMA, 318, 2306-2316. https://doi.org/10.1001/jama.2017.18718
|
[333]
|
Mun, E.J., Babiker, H.M., Weinber, U., et al. (2017) Tumor-Treating Fields: A Fourth Modality in Cancer Treatment. Clinical Cancer Research, 24, 266-275. https://doi.org/10.1158/1078-0432.CCR-17-1117
|
[334]
|
Szasz, O., Szigeti, G.P. and Szasz, A.M. (2017) Electrokinetics of Temperature for Development and Treatment of Effusions. Advances in Bioscience and Biotechnology, 8, 434-449. https://doi.org/10.4236/abb.2017.811032
|
[335]
|
Pang, C.L.K., Zhang, X., et al. (2017) Local Modulated Electro-Hyperthermia in Combination with Malignant Ascites: A Phase II Randomized Trial. Molecular and Clinical Oncology, 6, 723-732. https://doi.org/10.3892/mco.2017.1221
|
[336]
|
Vaupel, P.W. and Kelleher, D.K. (1996) Metabolic Status and Reaction to Heat of Normal and Tumor Tissue. In: Seegenschmiedt, M.H., Fessenden, P. and Vernon, C.C., Eds., Thermoradiotherapy and Thermochemotherapy: Biology, Physiology and Physics, Vol. 1, Springer Verlag, Berlin, 157-176. https://doi.org/10.1007/978-3-642-57858-8_8
|
[337]
|
Ferenczy, G.L. and Szasz, A. (2020) Ch. 3. Technical Challenges and Proposals in Oncological Hyperthermia. In: Szasz, A., Ed., Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars, Newcastle upon Tyne, 72-90. https://www.cambridgescholars.com/challenges-and-solutions-of-oncological-hyperthermia
|
[338]
|
Szentgyorgyi, A. (1968) Bioelectronics: A Study on Cellular Regulations, Defence and Cancer. Acad. Press, New York.
|
[339]
|
Szasz, O. (2013) Burden of Oncothermia—Why Is It Special? Conference Papers in Medicine, 2013, Article ID: 938689. http://www.hindawi.com/archive/2013/938689
|
[340]
|
Fiorentini, G. and Szasz, A. (2006) Hyperthermia Today: Electric Energy, a New Opportunity in Cancer Treatment. Journal of Cancer Research and Therapeutics, 2, 41-46. https://doi.org/10.4103/0973-1482.25848
|
[341]
|
Szasz, O. and Szasz, A. (2014) Oncothermia-Nano-Heating Paradigm. Journal of Cancer Science and Therapy, 6, 4. https://doi.org/10.4172/1948-5956.1000259
|
[342]
|
Szasz, A. (2013) Chapter 4. Electromagnetic Effects in Nanoscale Range. In: Shimizu, T. and Kondo, T., Eds., Cellular Response to Physical Stress and Therapeutic Applications, Nova Science Publishers, Inc., Hauppauge.
|
[343]
|
Vincze, G., Szigeti, G., Andocs, G. and Szasz, A. (2015) Nanoheating without Artificial Nanoparticles. Biology and Medicine, 7, 249.
|
[344]
|
Prasad, B., Kim, S., Cho, W., et al. (2018) Effect of Tumor Properties on Energy Absorption, Temperature Mapping, and Thermal Dose in 13.56-MHz Radiofrequency Hyperthermia. Journal of Thermal Biology, 74, 281-289. https://www.ncbi.nlm.nih.gov/pubmed/29801639
|
[345]
|
Lee, S.Y., Kim, J.H., et al. (2018) The Effect of Modulated Electro-Hyperthermia on Temperature and Blood Flow in Human Cervical Carcinoma. International Journal of Hyperthermia, 34, 953-960. https://doi.org/10.1080/02656736.2018.1423709
|
[346]
|
Szasz, O. (2013) Essentials of Oncothermia. Conference Papers in Medicine, 2013, Article ID: 159570. https://doi.org/10.1155/2013/159570
|
[347]
|
Wust, P., Ghadjar, P., Nadobny, J., et al. (2019) Physical Analysis of Temperature-Dependent Effects of Amplitude-Modulated Electromagnetic Hyperthermia. International Journal of Hypertension, 36, 1246-1254. https://doi.org/10.1080/02656736.2019.1692376
|
[348]
|
Szasz, A., Szasz, N. and Szasz, O. (2010) Oncothermia-Principles and Practices. Springer Science, Heidelberg. http://www.springer.com/gp/book/9789048194971
|
[349]
|
Szasz, O., Szasz, A.M., Minnaar, C. and Szasz, A. (2017) Heating Preciosity—Trends in Modern Oncological Hyperthermia. Open Journal of Biophysics, 7, 116-144. https://doi.org/10.4236/ojbiphy.2017.73010
|
[350]
|
Andocs, G., Renner, H., Balogh, L., Fonyad, L., Jakab, C. and Szasz, A. (2009) Strong Synergy of Heat and Modulated Electromagnetic Field in Tumor Cell Killing. Strahlentherapie und Onkologie, 185, 120-126. https://doi.org/10.1007/s00066-009-1903-1
|
[351]
|
Torok, Z., Crul, T., Maresca, B., et al. (2014) Plasma Membranes as Heat Stress Sensors: From Lipid-Controlled Molecular Switches to Therapeutic Applications. Biochimica et Biophysica Acta, 1838, 1594-1618. https://doi.org/10.1016/j.bbamem.2013.12.015
|
[352]
|
Staunton, J.R., Wirtz, D., Tlsty, T.D., et al. (2013) A Physical Sciences Network Characterization of Non-Tumorigenic and Metastatic Cells. Scientific Reports, 3, Article No. 1449. https://doi.org/10.1038/srep01449
|
[353]
|
Papp, E., Vancsik, T., Kiss, E. and Szasz, O. (2017) Energy Absorption by the Membrane Rafts in the Modulated Electro-Hyperthermia (mEHT). Open Journal of Biophysics, 7, 216-229. https://doi.org/10.4236/ojbiphy.2017.74016
|
[354]
|
Szasz, O. (2013) Renewing Oncological Hyperthermia-Oncothermia. Open Journal of Biophysics, 3, 245-252. https://doi.org/10.4236/ojbiphy.2013.34030
|
[355]
|
Szasz, O. (2019) Bioelectromagnetic Paradigm of Cancer Treatment-Modulated Electro-Hyperthermia (mEHT). OJBIPHY, 9, 98-109. https://doi.org/10.4236/ojbiphy.2019.92008
|
[356]
|
Meggyeshazi, N. andocs, G., Balogh, L., et al. (2014) DNA Fragmentation and Caspase-Independent Programmed Cell Death by Modulated Electrohyperthermia. Strahlentherapie und Onkologie, 190, 815-822. http://www.ncbi.nlm.nih.gov/pubmed/24562547
|
[357]
|
Yang, K.L., Huang, C.C., Chi, M.S., Chiang, H.C., Wang, Y.S. andocs, G., et al. (2016) In Vitro Comparison of Conventional Hyperthermia and Modulated Electro-Hyperthermia. Oncotarget, 7, 84082-84092. https://doi.org/10.18632/oncotarget.11444
|
[358]
|
Andocs, G., Meggyeshazi, N., Balogh, L., et al. (2014) Upregulation of Heat Shock Proteins and the Promotion of Damage-Associated Molecular Pattern Signals in a Colorectal Cancer Model by Modulated Electrohyperthermia. Cell Stress and Chaperones, 20, 37-46. http://www.ncbi.nlm.nih.gov/pubmed/24973890
|
[359]
|
Jeon, T.W., Yang, H., Lee, C.G., et al. (2016) Electro-Hyperthermia Up-Regulates Tumour Suppressor Septin 4 to Induce Apoptotic Cell Death in Hepatocellular Carcinoma. International Journal of Hypertension, 7, 1-9. https://doi.org/10.1080/02656736.2016.1186290
|
[360]
|
Meggyeshazi, N. (2015) Studies on Modulated Electrohyperthermia Induced Tumor Cell Death in a Colorectal Carcinoma Model. Thesis, Pathological Sciences Doctoral School, Semmelweis University, Budapest. http://repo.lib.semmelweis.hu/handle/123456789/3956
|
[361]
|
Andocs, G., Szasz, O. and Szasz, A. (2009) Oncothermia Treatment of Cancer: From the Laboratory to Clinic. Electromagnetic Biology and Medicine, 28, 148-165. https://doi.org/10.1080/15368370902724633
|
[362]
|
Fiorentini, G., Sarti, D., Casadei, V., et al. (2019) Modulated Electro-Hyperthermia as Palliative Treatment for Pancreas Cancer: A Retrospective Observational Study on 106 Patients. Integrative Cancer Therapies, 18, 1-8. https://doi.org/10.1177/1534735419878505
|
[363]
|
Szasz, A.M., Minnaar, C.A., Szentmartoni, G., et al. (2019) Review of the Clinical Evidences of Modulated Electro-Hyperthermia (Meht) Method: An Update for the Practicing Oncologist. Frontiers in Oncology, 9, Article No. 1012. https://doi.org/10.3389/fonc.2019.01012
|
[364]
|
Minnaar, C.A., Kotzen, J.A., Ayeni, O.A., et al. (2019) The Effect of Modulated Electro-Hyperthermia on Local Disease Control in HIV-Positive and -Negative Cervical Cancer Women in South Africa: Early Results from a Phase III Randomized Controlled Trial. PLOS ONE, 14, e0217894. https://doi.org/10.1371/journal.pone.0217894
|
[365]
|
Vincze, G., Szasz, O. and Szasz, A. (2015) Generalization of the Thermal Dose of Hyperthermia in Oncology. Open Journal of Biophysics, 5, 97-114. https://doi.org/10.4236/ojbiphy.2015.54009
|
[366]
|
Vincze, G. and Szasz, A. (2018) Similarities of Modulation by Temperature and by Electric Field. OJBIPHY, 8, 95-103. https://doi.org/10.4236/ojbiphy.2018.83008
|
[367]
|
Szasz, A., Vincze, G., Szasz, O. and Szasz, N. (2003) An Energy Analysis of Extracellular Hyperthermia. Magneto- and Electro-Biology, 22, 103-115. https://doi.org/10.1081/JBC-120024620
|
[368]
|
Hegyi, G., Szasz, O. and Szasz, A. (2013) Oncothermia: A New Paradigm and Promising Method in Cancer Therapies. Acupuncture & Electro-Therapeutics Research: The International Journal, 38, 161-197. https://doi.org/10.3727/036012913X13831832269243
|
[369]
|
Hegyi, G., Szigeti, G.P. and Szasz, A. (2013) Hyperthermia versus Oncothermia: Cellular Effects in Complementary Cancer Therapy. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID: 672873. https://doi.org/10.1155/2013/672873
|
[370]
|
Lee, S.Y., Szigeti, G.P. and Szasz, A.M. (2018) Oncological Hyperthermia: The Correct Dosing in Clinical Applications. International Journal of Oncology, 54, 627-643. https://doi.org/10.3892/ijo.2018.4645
|
[371]
|
Hager, D., Dziambor, H., Hoehmann, D., et al. (2002) Survival and Quality of Life of Patients with Advanced Pancreatic Cancer. Annual Meeting of the American Society of Clinical Oncology, Orlando, 18-21 May 2002, 2359.
|
[372]
|
Ou, J., Zhu, X., Chen, P., et al. (2020) A Randomized Phase II Trial of Best Supportive Care with or without Hyperthermia and Vitamin C for Heavily Pretreated, Advanced, Refractory Non-Small-Cell Lung Cancer. Journal of Advanced Research, 24, 175-182. https://www.ncbi.nlm.nih.gov/pubmed/32368355
|
[373]
|
Prasad, B., Kim, S., Cho, W., et al. (2019) Quantitative Estimation of the Equivalent Radiation Dose Escalation Using Radiofrequency Hyperthermia in Mouse Xenograft Models of Human Lung Cancer. Scientific Reports, 9, Article No. 3942. https://doi.org/10.1038/s41598-019-40595-6
|
[374]
|
Vancsik, T., Forika, G., Balogh, A., et al. (2019) Modulated Electro-Hyperthermia Induced P53 Driven Apoptosis and Cell Cycle Arrest Additively Support Doxorubicin Chemotherapy of Colorectal Cancer in Vitro. Cancer Medicine, 8, 4292-4303. https://doi.org/10.1002/cam4.2330
|
[375]
|
Tsang, Y.W., Chi, K.H., et al. (2019) Modulated Electro-Hyperthermia-Enhanced Liposomal Drug Uptake by Cancer Cells. International Journal of Nanomedicine, 14, 1269-1579. https://doi.org/10.2147/IJN.S188791
|
[376]
|
Roussakow, S. (2013) The History of Hyperthermia Rise and Decline. Conference Papers in Medicine, 2013, Article ID: 201671. http://www.hindawi.com/journals/cpis/2013/428027
|
[377]
|
Szasz, A., Szasz, N. and Szasz, O. (2013) Local Hyperthermia in Oncology—to Choose or Not to Choose? In: Huilgol, N., Ed., Hyperthermia, InTech, London, 1-82. https://doi.org/10.5772/52208
|
[378]
|
Vernon, C.C., Hand, J.W., Field, S.B., et al. (1996) Radiotherapy with or without Hyperthermia in the Treatment of Superficial Localized Breast Cancer: Results from Five Randomized Controlled Trials. International Journal of Radiation Oncology, Biology, Physics, 35, 731-744. https://doi.org/10.1016/0360-3016(96)00154-X
|
[379]
|
Sherar, M., Liu, F.F., Pintilie, M., et al. (1997) Relationship between Thermal Dose and Outcome in Thermoradiotherapy Treatments for Superficial Recurrences of Breast Cancer: Data from a Phase III Trial. International Journal of Radiation Oncology, Biology, Physics, 39, 371-380. https://doi.org/10.1016/S0360-3016(97)00333-7
|
[380]
|
Zolciak-Siwinska, A., Piotrokowicz, N., Jonska-Gmyre, J., et al. (2013) HDR Brachytherapy Combined with Interstitial Hyperthermia in Locally Advanced Cervical Cancer Patients Initially Treated with Concomitant Radiochemotherapy—A Phase III Study. Radiotherapy and Oncology, 109, 194-199. https://doi.org/10.1016/j.radonc.2013.04.011
|
[381]
|
Kay, C.S., Choi, I.B., Jang, J.Y., Choi, B.O., Kim, I.A., Shinn, K.S., et al. (1996) Thermoradiotherapy in the Treatment of Locally Advanced Nonsmall Cell Lung Cancer. The Journal of the Korean Society for Therapeutic Radiology and Oncology, 14, 115-122. https://doi.org/10.1016/0169-5002(96)85955-1
|
[382]
|
Jones, E.L., Oleson, J.R., Prosnith, L.R., et al. (2007) Randomized Trial of Hyperthermia and Radiation for Superficial Tumours. Journal of Clinical Oncology, 23, 3079-3085. https://doi.org/10.1200/JCO.2005.05.520
|
[383]
|
Mitsumori, M., Zhi-Fan, Z., Oliynychenko, P., et al. (2007) Regional Hyperthermia Combined with Radiotherapy for Locally Advanced Non-Small Cell Lung Cancers: A Multi-Institutional Prospective Randomized Trial of the International Atomic Energy Agency. International Journal of Clinical Oncology, 12, 192-198. https://doi.org/10.1007/s10147-006-0647-5
|
[384]
|
Barker, A.T., Jaffe, L.F. and Vanable, J.W. (1982) The Glabrous Epidermis of Cavies Contains a Powerful Battery. American Journal of Physiology, 242, R358-R366. https://doi.org/10.1152/ajpregu.1982.242.3.R358
|
[385]
|
Rosch, P.J. and Markov, M.S. (2004) Bioelectromagnetic Medicine. Marcell Decker Inc., New York. https://doi.org/10.3109/9780203021651
|
[386]
|
Samuelsson, L., Jonsson, L. and Stahl, E. (1983) Percutaneous Treatment of Pulmonary Tumors by Electrolysis. Radiologie, 23, 284-287. https://doi.org/10.1016/0011-2275(83)90154-6
|
[387]
|
Song, B., Zhao, M., Forrester, J., et al. (2004) Nerve Regeneration and Wound Healing Are Stimulated and Directed by an Endogenous Electrical Field in Vivo. Journal of Cell Science, 117, 4681-4690. https://doi.org/10.1242/jcs.01341
|
[388]
|
Carbon, M., Wübbeler, G., Mackert, B.M., et al. (2004) Non-Invasive Magnetic Detection of Human Injury Currents. Clinical Neurophysiology, 115, 1027-1032. https://doi.org/10.1016/j.clinph.2003.12.035
|
[389]
|
Reid, B., Nuccitelli, R. and Zhao, M. (2007) Non-Invasive Measurement of Bioelectric Currents with a Vibrating Probe. Nature Protocols, 2, 661-669. https://doi.org/10.1038/nprot.2007.91
|
[390]
|
Mackert, B.M., Mackert, J., Wübbeler, G., et al. (1999) Magnetometry of Injury Currents from Human Nerve and Muscle Specimens Using Superconducting Quantum Interferences Devices. Neuroscience Letters, 262, 163-166. https://doi.org/10.1016/S0304-3940(99)00067-1
|
[391]
|
Zhao, M., Forrester, J.V. and McCaig, C.D. (1999) A Small, Physiological Electric Field Orients Cell Division. Proceedings of the National Academy of Sciences of the United States of America, 96, 4942-4946. https://doi.org/10.1073/pnas.96.9.4942
|
[392]
|
Song, B., Zhao, M., Forrester, J.V., et al. (2002) Electrical Cues Regulate the Orientation and Frequency of Cell Division and the Rate of Wound Healing in Vivo. PNAS, 99, 13577-13582. https://doi.org/10.1073/pnas.202235299
|
[393]
|
Zhao, M. (2009) Electrical Fields in Wound Healing—An Overriding Signal That Directs Cell Migration. Seminars in Cell & Developmental Biology, 20, 674-682. https://doi.org/10.1016/j.semcdb.2008.12.009
|
[394]
|
Huttenlocher, A. (2007) Wound Healing with Electric Potential. NEJM, 356, 304-305. https://doi.org/10.1056/NEJMcibr066496
|
[395]
|
Becker, R.O. and Selden, G. (1985) The Body Electric. Morrow, New York.
|
[396]
|
Becker, R.O. (1990) Cross Currents. Jeremy P Tarcher Inc., Los Angeles.
|
[397]
|
McCaig, C.D., Rajnicek, A.M., Song, B., et al. (2005) Controlling Cell Behaviour Electrically: Current Views and Future Potential. Physiological Reviews, 85, 943-978. https://doi.org/10.1152/physrev.00020.2004
|
[398]
|
Rosenberg, S.M. and Queitsch, C. (2014) Combating Evolution to Fight Disease. Science, 343, 1088-1089. https://doi.org/10.1126/science.1247472
|
[399]
|
Galluzzi, L., Zitvogel, L. and Kroemer, G. (2016) Immunological Mechanisms underneath the Efficacy of Cancer Therapy. Cancer Immunology Research, 4, 895-902. https://doi.org/10.1158/2326-6066.CIR-16-0197
|
[400]
|
Waldhauer, I. and Steinle, A. (2008) NK Cells and Cancer Immunosurveillance. Oncogene, 27, 5932-5943. https://doi.org/10.1038/onc.2008.267
|
[401]
|
Zamai, L., Ponti, C., Mirandola, P., et al. (2007) NK Cells and Cancer. The Journal of Immunology, 178, 4011-4016. https://doi.org/10.4049/jimmunol.178.7.4011
|
[402]
|
Hu, W., Wang, G., Huang, D., et al. (2019) Cancer Immunotherapy Based on Natural Cell Killer Cells: Current Progress and New Opportunities. Frontiers in Immunology, 10, Article No. 1205. https://doi.org/10.3389/fimmu.2019.01205
|
[403]
|
Bassani, B., Baci, D. and Gallazzi, M. (2019) Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects. Cancers, 11, 461. https://doi.org/10.3390/cancers11040461
|
[404]
|
Betten, A., Dahlgren, C., Mellqvist, U.H., et al. (2004) Oxygen Radical-Induced Natural Killer Cell Dysfunction: Role of Myeloperosicase and Regulation by Serotonin. Journal of Leukocyte Biology, 75, 1111-1115. https://doi.org/10.1189/jlb.1103595
|
[405]
|
Sag, D., Ayyildiz, Z.O., Gunalp, S., et al. (2019) The Role of TRAIL/Drs in the Modulation of Immune Cells and Responses. Cancers, 11, 1469. https://doi.org/10.3390/cancers11101469
|
[406]
|
Wajant, H. (2019) Molecular Mode of Action of TRAIL Receptor Agonists Common Principles and Their Translational Exploitation. Cancers, 11, 954. https://doi.org/10.3390/cancers11070954
|
[407]
|
Mifsud, E.J., Tan, A.C.L. and Jacks, D.C. (2014) TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents against Infectious Disease. Frontiers in Immunology, 5, Article No. 79. https://doi.org/10.3389/fimmu.2014.00079
|
[408]
|
Meggyeshazi, N. andocs, G., et al. (2013) Early Changes in mRNA and Protein Expression Related to Cancer Treatment by Modulated Electro-Hyperthermia. Conference Papers in Medicine, 2013, Article ID: 249563. http://www.hindawi.com/archive/2013/249563
|
[409]
|
Masuda, Y., Nawa, D. and Nakayama, Y. (2015) Soluble b-Glucan from Grifola frondosa Induces Tumor Regression in Synergy with TLR9 Agonist via Dendritic Cell-Mediated Immunity. Journal of Leukocyte Biology, 98, 1015-1025. https://doi.org/10.1189/jlb.1A0814-415RR
|
[410]
|
Showalter, A., Limaye, A. and Oyer, J.L. (2017) Cytokines in Immunogenic Cell Death: Applications for Cancer Immonotherapy. Cytokine, 97, 123-132. https://doi.org/10.1016/j.cyto.2017.05.024
|
[411]
|
Krysko, O., Aaes, T.L. and Bachert, C. (2013) Many Faces of DAMPs in Cancer Therapy. Cell Death and Disease, 4, e631. https://doi.org/10.1038/cddis.2013.156
|
[412]
|
Hernandez, C., Huebener, P. and Schwabe, R.F. (2016) Damage Associated Molecular Patterns in Cancer: A Double-Edged Sword. Oncogene, 35, 5931-5941. https://doi.org/10.1038/onc.2016.104
|
[413]
|
Repasky, E.A. and Evans, S.S. (2013) Temperature Matters! And Why It Should Matter to Tumor Immunologists. Cancer Immunology Research, 1, 210-216. https://doi.org/10.1158/2326-6066.CIR-13-0118
|
[414]
|
Dieing, A., Ashlers, O. and Hildebrandt, B. (2007) The Effect of Induced Hyperthermia on the Immune System. Progress in Brain Research, 162, 137-152. https://doi.org/10.1016/S0079-6123(06)62008-6
|
[415]
|
Sulyok, I., Fleishmann, E. and Stift, A. (2012) Effect of Preoperative Fever-Range Whole-Body Hyperthermia on Immunological Markers in Patients Undergoing Colorectal Cancer Surgery. British Journal of Anaesthesia, 109, 754-761. https://doi.org/10.1093/bja/aes248
|
[416]
|
Shen, R.N., Lu, L., Young, P., Shidnia, H., Hornback, N.B. and Broxmeyer, H.E. (1994) Influence of Elevated Temperature on Natural Killer Cell Activity, Lymphokine-Activated Killer Cell Activity and Lecitin-Dependent Cytotoxicity of Human Umbilical Cord Blood and Adult Blood Cell. International Journal of Radiation Oncology, Biology, Physics, 29, 821-826. https://doi.org/10.1016/0360-3016(94)90571-1
|
[417]
|
Hietanen, T., Kapanen, M. and Kellokumpu-Lehtinen, P.L. (2016) Restoring Natural Killer Cell Cytotoxicity after Hyperthermia Alone or Combined with Radiotherapy. Anticancer Research, 36, 555-564.
|
[418]
|
Beachy. S.H. and Repasky, E.A. (2011) Toward Establishment of Temperature Thresholds for Immunological Impact of Heat Exposure in Humans. International Journal of Hyperthermia, 27, 344-352. https://doi.org/10.3109/02656736.2011.562873
|
[419]
|
Staunton, J.R., et al. (2008) The Physical Sciences-Oncology Centers Network, a Physical Sciences Network Characterization of Non-Tumorigenic and Metastatic Cells. Scientific Reports, 3, Article No. 1449.
|
[420]
|
Szasz, A. (2019) Thermal and Nonthermal Effects of Radiofrequency on Living State and Applications as an Adjuvant with Radiation Therapy. Journal of Radiation and Cancer Research, 10, 1-17. https://doi.org/10.4103/jrcr.jrcr_25_18
|
[421]
|
Vincze, G. and Szasz, A. (2015) Effect of Cellular Membrane Resistivity Inhomogeneity on the Thermal Noise-Limit. Journal of Advances in Physics, 11, 3170-3183. https://doi.org/10.24297/jap.v11i3.6859
|
[422]
|
Ye, L., Zhang, T. and Kang, Z. (2019) Tumor-Infiltrating Immune Cells Act as a Marker for Prognosis in Colorectal Cancer. Frontiers in Immunology, 10, Article No. 2368. https://doi.org/10.3389/fimmu.2019.02368
|
[423]
|
Mole, R.H. (1953) Whole Body Irradiation-Radiology or Medicine? British Journal of Radiology, 26, 234-241. https://doi.org/10.1259/0007-1285-26-305-234
|
[424]
|
Cavanagh, W. (2009) The Abscopal Effect and the Prospect of Using Cancer against Itself, Prostate Cancer Research Institute. PCRI Insights, Vol. 12.1.
|
[425]
|
Wersäll, P.J., Blomgren, H., Pisa, P., Lax, I., Kälkner, K.M. and Svedman, C. (2006) Regression of Non-Irradiated Metastases after Extracranial Stereotactic Radiotherapy in Metastatic Renal Cell Carcinoma. Acta Oncologica, 45, 493-497. https://doi.org/10.1080/02841860600604611
|
[426]
|
Trott, K.R. (2001) Non-Targeted Radiation Effects in Radiotherapy-Roles of Radiation-Induced Genomic Instability and of the Bystander Effect in Cancer Cure by Radiotherapy. Acta Oncologica, 40, 976-980. https://doi.org/10.1080/02841860152708260
|
[427]
|
Hartford, A., Gohongi, T., Fukumura, D. and Jain, R. (2000) Irradiation of a Primary Tumor, Unlike Surgical Removal, Enhances Angiogenesis Suppression at a Distal Site: Potential Role of Host-Tumor Interaction. Cancer Research, 60, 2128-2131.
|
[428]
|
Uchida, A., Mizutani, Y., Nagamuta, M. and Ikenaga, M. (1989) Elevation of Sensitivity of Tumor Cells and Lytic Function of NK Cells. Immunopharmacology and Immunotoxicology, 11, 507-519. https://doi.org/10.3109/08923978909005381
|
[429]
|
Tubin, S. and Raunik, W. (2017) Hunting for Abscopal and Bystander Effects: Clinical Exploitation of Non-Targeted Effects Induced by Partial High-Single-Dose Irradiation of the Hypoxic Tumour Segment in Oligometastatic Patients. Acta Oncologica, 56, 1333-1339. https://doi.org/10.1080/0284186X.2017.1346385
|
[430]
|
Pouget, J.P., Georgakilas, A.G. and Ravanat, J.L. (2018) Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanism and Risk/Benefit Analysis. Antioxidant & Redox Signaling, 29, 1447-1487. https://doi.org/10.1089/ars.2017.7267
|
[431]
|
Wang, R., Zhou, T., Liu, W. and Zuo, L. (2018) Molecular Mechanism of Bystander Effects and Related Abscopal/Cohort Effects in Cancer Therapy. Oncotarget, 9, 18637-18647. https://doi.org/10.18632/oncotarget.24746
|
[432]
|
Demaria, S., Ng, B., Devitt, M.L., Babb, J.S., Kawashima, N., Liebes, L. and Formenti, S.C. (2004) Ionizing Radiation Inhibition of Distant Untreated Tumors (Abscopal Effect) Is Immune Mediated. International Journal of Radiation Oncology, Biology, Physics, 58, 862-870. https://doi.org/10.1016/j.ijrobp.2003.09.012
|
[433]
|
Kaminski, J.M., Shinohara, E., Summers, J.B., Niermann, K.J., Morimoto, A. and Brousal, J. (2005) The Controversial Abscopal Effect. Cancer Treatment Reviews, 31, 159-172. https://doi.org/10.1016/j.ctrv.2005.03.004
|
[434]
|
Porter, D.L., Levine, B.L., Kalos, M., Bagg, A. and June, C.H. (2011) Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia. The New England Journal of Medicine, 365, 725-733. https://doi.org/10.1056/NEJMoa1103849
|
[435]
|
Nobler, M. (1969) The Abscopal Effect in Malignant Lymphoma and Its Relationship Tolymphocyte Circulation. Radiology, 93, 410-412. https://doi.org/10.1148/93.2.410
|
[436]
|
Antoniades, J., Brady, L. and Lightfoot, D. (1977) Lymphangiographic Demonstration of the Abscopal Effect in Patients with Malignant Lymphomas. International Journal of Radiation Oncology, Biology, Physics, 2, 141-147. https://doi.org/10.1016/0360-3016(77)90020-7
|
[437]
|
Formenti, S.C. and Demaria, S. (2009) Systemic Effects of Local Therapy. The Lancet Oncology, 10, 718-726. https://doi.org/10.1016/S1470-2045(09)70082-8
|
[438]
|
Rees, G.J. (1981) Abscopal Regression in Lymphoma: A Mechanism in Common with Total Body Irradiation? Clinical Radiology, 32, 475-480. https://doi.org/10.1016/S0009-9260(81)80310-8
|
[439]
|
Ehlers, G. and Fridman, M. (1973) Abscopal Effect of Radiation in Papillary Adenocarcinoma. The British Journal of Radiology, 46, 220-222. https://doi.org/10.1259/0007-1285-46-543-220
|
[440]
|
Kingsley, D. (1975) An Interesting Case of Possible Abscopal Effect in Malignant Melanoma. The British Journal of Radiology, 48, 863-866. https://doi.org/10.1259/0007-1285-48-574-863
|
[441]
|
Rees, G. and Ross, C. (1983) Abscopal Regression Following Radiotherapy for Adenocarcinoma. The British Journal of Radiology, 56, 63-66. https://doi.org/10.1259/0007-1285-56-661-63
|
[442]
|
Rees, G.J.G., Ross, C.M.D. and Path, F.R.C. (1983) Abscopal Regression Following Radiotherapy for Adenocarcinoma. British Journal of Radiology, 56, 63-66. https://doi.org/10.1259/0007-1285-56-661-63
|
[443]
|
Lakshmanagowda, P.B., Viswanath, L., Thimmaiah, N., Dasappa, L., Supe, S.S. and Kallur, P. (2009) Abscopal Effect in a Patient with Chronic Lymphocytic Leukemia during Radiation Therapy: A Case Report. Cases Journal, 2, 204. https://www.casesjournal.com/content/2/1/204
|
[444]
|
Sham, R. (1995) The Abscopal Effect and Chronic Lymphocytic Leukemia. The American Journal of Medicine, 98, 307-308. https://doi.org/10.1016/S0002-9343(99)80380-5
|
[445]
|
Smith, J.A. and Herr, H.W. (1979) Spontaneous Regression of Pulmonary Metastases from Transitional Cell Carcinoma. Cancer, 46, 1499-1502. https://doi.org/10.1002/1097-0142(19800915)46:6<1499::AID-CNCR2820460634>3.0.CO;2-G
|
[446]
|
Van der Meeren, A., Monti, P., Vandamme, M., Squiban, C., Wysocki, J. and Griffiths, N. (2005) Abdominal Radiation Exposure Elicits Inflammatory Responses and Abscopal Effects in the Lungs of Mice. Radiation Research, 163, 144-152. https://doi.org/10.1667/RR3293
|
[447]
|
Ohba, K., Omagari, K., Nakamura, T., Ikuno, N., Saeki, S., Matsuo, I., Kinoshita, H., Masuda, J., Hazama, H., Sakamoto, I. and Kohno, S. (1998) Abscopal Regression of Hepatocellular Carcinoma after Radiotherapy for Bone Metastasis. Gut, 43, 575-577. https://doi.org/10.1136/gut.43.4.575
|
[448]
|
Nakanishi, M., Chuma, M., Hige, S. and Asaka, M. (2008) Abscopal Effect on Hepatocellular Carcinoma. The American Journal of Gastroenterology, 103, 1320-1321. https://doi.org/10.1111/j.1572-0241.2007.01782_13.x
|
[449]
|
Menon, H., Chen, D. and Ramapriyan, R. (2019) Influence of Low-Dose Radiation on Abscopal Responses in Patients Receiving High-Dose Radiation and Immunotherapy. Journal for ImmunoTherapy of Cancer, 7, 237. https://doi.org/10.1186/s40425-019-0718-6
|
[450]
|
Zahidunnabi, M., et al. (2009) Fractionated But Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect When Combined with Anti-CTLA-4 Antibody. Clinical Cancer Research, 15, 5379-5388. https://doi.org/10.1158/1078-0432.CCR-09-0265
|
[451]
|
Liu, Y., Dong, Y. and Kong, L. (2018) Abscopal Effect of Radiotherapy Combined with Immune Checkpoint Inhibitors. Journal of Hematology & Oncology, 11, 104. https://doi.org/10.1186/s13045-018-0647-8
|
[452]
|
Dagoglu, N., Karaman, S., Caglar, H.B., et al. (2019) Abscopal Effect of Radiotherapy in the Immunotherapy Era: Systematic Review of Reported Cases. Cureus, 11, e4103. https://doi.org/10.7759/cureus.4103
|
[453]
|
Lauber, K. and Dunn, L. (2019) Immunotherapy Mythbusters in Head and Neck Cancer: The Abscopal Effect and Pseudoprogression. American Society of Clinical Oncology Educational Book, 39, 352-363. https://doi.org/10.1200/EDBK_238339
|
[454]
|
Liu, J. and Mackley, H.B. (2019) Combining Immunotherapy with Radiation Therapy to Induce the Abscopal Response: What Clinical and Treatment Variables Matter? Applied Radiation Oncology, 8, 13-19.
|
[455]
|
Yilmaz, M.T., Elmali, A. and Yazici, G. (2019) Abscopal Effect: From Myth to Reality from Radiation Oncologists’ Perspective. Cureus, 11, e3860. https://doi.org/10.7759/cureus.3860
|
[456]
|
Seidi, K., Zarghami, N. and Jahanban-Esfahlan, R. (2013) Proposed Approach for Revealing Unknown Mediators of Abscopal. Journal of Medical Hypotheses and Ideas, 7, 43-49. https://doi.org/10.1016/j.jmhi.2013.03.001
|
[457]
|
Keisari, Y. (2013) Tumor Ablation, Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment. Springer, Berlin. https://doi.org/10.1007/978-94-007-4694-7
|
[458]
|
Wang, H., Zhang, L. and Shi, Y. (2013) Abscopal Antitumor Immune Effects of Magnet-Mediated Hyperthermia at a High Therapeutic Temperature on Walker-256 Carcinosarcomas in Rats. Oncology Letters, 7, 764-770. https://doi.org/10.3892/ol.2014.1803
|
[459]
|
Persson, B.R.R., Koch, C., Graftsröm, G., et al. (2004) Abscopal Regression of Subcutaneously Implanted N29 Rat Glioma after Treatment of the Contra-Lateral Tumours with Pulsed Electric Fields (PEF) or Radiation Therapy (RT) and Their Combinations (PEF+RT). Cancer Therapy, 2, 533-548. https://doi.org/10.1177/153303460300200512
|
[460]
|
Falk, R.E., Moffa, F.L. and Lawler, M. (1985) Combination Therapy for Resectable and Unresectable Adenocarcinoma of the Pancreas. Cancer, 57, 685-688. https://doi.org/10.1002/1097-0142(19860201)57:3<685::AID-CNCR2820570348>3.0.CO;2-X
|
[461]
|
Oei, A.L., Korangath, P. and Mulka, K. (2019) Enhancing the Abscopal Effect of Radiation and Immune Checkpoint Inhibitor Therapies with Magnetic Nanoparticle Hyperthermia in a Model of Metastatic Breast Cancer. International Journal of Hyperthermia, 36, 47-63. https://doi.org/10.1080/02656736.2019.1685686
|
[462]
|
Dank, M., Meggyeshazi, N., Szigeti, G. and Andocs, G. (2016) Immune Effects by Selective Heating of Membrane Rafts of Cancer-Cells. Journal of Clinical Oncology, 34, e14571. https://meetinglibrary.asco.org/record/124231/abstract
|
[463]
|
Ngwa, W., Irabor, O.C. and Schoenfield, J.D. (2018) Using Immunotherapy to Boost the Abscopal. Nature Reviews Cancer, 18, 313-322. https://doi.org/10.1038/nrc.2018.6
|
[464]
|
Honkoop, A.H., Luykx-de, Bakker, S.A., Hoekman, K., Meyer, S., Meyer, O.W., van Groeningen, C.J., van Diest, P.J., Boven, E., van der Wall, E., Giaccone, G., Wagstaff, J. and Pinedo, H.M. (1999) Prolonged Neoadjuvant Chemotherapy with GM-CSF in Locally Advanced Breast Cancer. Oncologist, 4, 106-111. https://doi.org/10.1634/theoncologist.4-2-106
|
[465]
|
Spitler, L.E., Weber, R.W., Allen, R.E., Meyer, J., Cruickshank, S., Garbe, E., Lin, H.Y. and Soong, S.J. (2009) Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF, Ssargramostim) Administered for 3 Years as Adjuvant Therapy of Stages II(T4), III, and IV Melanoma. Journal of Immunotherapy, 32, 632-637. https://doi.org/10.1097/CJI.0b013e3181a7d60d
|
[466]
|
Leary, R., Gardner, R.B. and Mockbee, C. (2019) Boosting Abscopal Response to Radiotherapy with Sargramostim: A Review of Data and Ongoing Studies. Cureus, 11, e4276. https://doi.org/10.7759/cureus.4276
|
[467]
|
Fiorentini, G., Yoon, S.M., Yan, O. andocs, G., Baronzio, G.F., Laurent, S., Balogh, L. and Szasz, A. (2013) Abscopal Effect: New Perspectives in Oncothermia. Oncothermia Journal, 7, 279-281. https://oncotherm.com/sites/oncotherm/files/2017-07/Abscopal_effect_new_perspectives_in_Oncothermia_T.pdf
|
[468]
|
Andocs, G., Meggyeshazi, N., Okamoto, Y., Balogh, L. and Szasz, O. (2013) Bystander Effect of Oncothermia. Conference Papers in Medicine, 2013, Article ID: 953482. https://doi.org/10.1155/2013/953482
|
[469]
|
Derer, A., Deloch, L. and Rubner, Y. (2015)-Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses-pre-Clinical Evidence and Ongoing Clinical Applications. Frontiers in Immunology, 6, Article No. 505. https://doi.org/10.3389/fimmu.2015.00505
|
[470]
|
Vancsik, T., Kovago, C., Kiss, E., et al. (2018) Modulated Electro-Hyperthermia Induced Loco-Regional and Systemic Tumor Destruction in Colorectal Cancer Allografts. Journal of Cancer, 9, 41-53. https://doi.org/10.7150/jca.21520
|
[471]
|
Qin, W., Akutsu, Y. andocs, G., et al. (2014) Modulated Electro-Hyperthermia Enhances Dendritic Cell Therapy through an Abscopal Effect in Mice. Oncology Reports, 32, 2373-2379. https://doi.org/10.3892/or.2014.3500
|
[472]
|
Tsang, Y.W., Huang, C.C., Yang, K.L., et al. (2015) Improving Immunological Tumor Microenvironment Using Electro-Hyperthermia Followed by Dendritic Cell Immunotherapy. BMC Cancer, 15, Article No. 708. https://doi.org/10.1186/s12885-015-1690-2
|
[473]
|
Andocs, G., Szasz, A., Szasz, O. and Iluri, N. (2016) Tumor Vaccination Patent. EP2780024B1. US20150217099A1. https://patents.google.com/patent/EP2780024B1/en
|
[474]
|
Iyikesici, M.S., Slocum, A.K., Slocum, A., et al. (2017) Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer. Cureus, 9, e1445. https://doi.org/10.7759/cureus.1445
|
[475]
|
Schirrmacher, V. (2015) Oncolytic Newcastle Disease Virus as a Prospective Anti-Cancer Therapy. A Biologic Agent with Potential to Break Therapy Resistance. Expert Opinion on Biological Therapy, 15, 1757-1771. https://doi.org/10.1517/14712598.2015.1088000
|
[476]
|
Schirrmacher, V., Lorenzen, D., Van Gool, S.W., et al. (2017) A New Strategy of Cancer Immunotherapy Combining Hyperthermia/Oncolytic Virus Pretreatment with Specific Autologous Anti-Tumor Vaccination—A Review. Austin Oncology Case Reports, 2, 1006. https://doi.org/10.26420/austinoncolcaserep.1006.2017
|
[477]
|
Schirrmacher, V., Stücker, W., Lulei, M., et al. (2015) Long-Term Survival of a Breast Cancer Patient with Extensive Liver Metastases upon Immune and Virotherapy: A Case Report. Immunotherapy, 7, 855-860. https://doi.org/10.2217/imt.15.48
|
[478]
|
Schirrmacher, V., Bihari, A.S., Stücker, W., et al. (2014) Long-Term Remission of Prostate Cancer with Extensive Bone Metastases upon Immuno- and Virotherapy: A Case Report. Oncology Letters, 8, 2403-2406. https://doi.org/10.3892/ol.2014.2588
|
[479]
|
Van Gool, S.W., Makalowski, J., Feyen, O., Prix, L., Schirrmacher, V. and Stuecker, W. (2018) The Induction of Immunogenic Cell Death (ICD) during Maintenance Chemotherapy and Subsequent Multimodal Immunotherapy for Glioblastoma (GBM). Austin Oncology Case Reports, 3, 1010.
|
[480]
|
Ben-Jacob, E. (2013) Engineering Trojan-Horse Bacteria to Fight Cancer. Inside Blood, 122, 705-706. https://doi.org/10.1182/blood-2013-06-508481
|
[481]
|
Kleef, R., Kekic, S. and Ludwig, N. (2012) Successful Treatment of Advanced Ovarian Cancer with Thermochemotherapy and Adjuvant Immune Therapy. Case Reports in Oncology, 5, 212-215. https://doi.org/10.1159/000338617
|
[482]
|
Minnaar, C.A., Szigeti, G.P., et al. (2018) Modulated Electro-Hyperthermia as a Monotherapy: A Potential for Further Research? 36th ICHS Conference, Budapest, 28-29 September 2018.
|
[483]
|
Roussakow, S. (2017) Clinical and Economic Evaluation of Modulated Electrohyperthermia Concurrent to Dose-Dense Temozolomide 21/28 Days Regimen in the Treatment of Recurrent Glioblastoma: A Retrospective Analysis of a Two-Centre German Cohort Trial with Systematic Comparison and Effect-to-Treatment Analysis. BMJ Open, 7, e017387. http://bmjopen.bmj.com/content/bmjopen/7/11/e017387.full.pdf
|
[484]
|
Hager, E.D., Sahinbas, H., Groenemeyer, D.H., et al. (2008) Prospective Phase II Trial for Recurrent High-Grade Malignant Gliomas with Capacitive Coupled Low Radiofrequency (LRF) Deep Hyperthermia. Journal of Clinical Oncology, (Post-Meeting Edition), 26, 2047. https://doi.org/10.1200/jco.2008.26.15_suppl.2047
|
[485]
|
Sahinbas, H., Groenemeyer, D.H.W., Boecher, E. and Szasz, A. (2007) Retrospective Clinical Study of Adjuvant Electro-Hyperthermia Treatment for Advanced Brain-Gliomas. Deutsche Zeitschrift fuer Onkologie, 39, 154-160. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-986020
|
[486]
|
Fiorentini, G., Sarti, D., Milandri, C., et al. (2018) Modulated Electrohyperthermia in Integrative Cancer Treatment for Relapsed Malignant Glioblastoma and Astrocytoma: Retrospective Multicenter Controlled Study. Integrative Cancer Therapies, 18, 1534735418812691. https://www.ncbi.nlm.nih.gov/pubmed/30580645
|
[487]
|
Szasz, A. (2014) Current Status of Oncothermia Therapy for Lung Cancer. The Korean Journal of Thoracic and Cardiovascular Surgery, 47, 77-93. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000888
|
[488]
|
Lee, D.J., Haam, S.J., Kim, T.H., et al. (2013) Oncothermia with Chemotherapy in the Patients with Small Cell Lung Cancer. Conference Papers in Medicine, 2013, Article ID: 910363. http://www.hindawi.com/archive/2013/910363
|
[489]
|
Lee, S.Y., Lee, N.R., Cho, D.H., et al. (2017) Treatment Outcome Analysis of Chemotherapy Combined with Modulated Electro-Hyperthermia Compared with Chemotherapy Alone for Recurrent Cervical Cancer, Following Irradiation. Oncology Letters, 14, 73-78. http://www.spandidos-publications.com/10.3892/ol.2017.6117
|
[490]
|
Jeung, T.S., Ma, S.Y., Yu, J., et al. (2013) Cases that Respond to Oncothermia Monotherapy. Conference Papers in Medicine, 2013, Article ID: 392480. https://www.hindawi.com/journals/cpis/2013/392480 https://doi.org/10.1155/2013/392480
|
[491]
|
Nixon, R. (1971) National Cancer Act. The Time of Declaration. https://www.cancer.gov/about-nci/overview/history/national-cancer-act-1971
|
[492]
|
Yeung, K.S., Gubili, J. and Mao, J.J. (2018) Herb-Drug Interactions in Cancer Care. Oncology (Williston Park), 32, 516-520.
|
[493]
|
McEwen, B.S. (2006) Protective and Damaging Effects of Stress Mediators: Central Role of the Brain. Dialogus in Clinical Neuroscience, 8, 367-381. https://doi.org/10.31887/DCNS.2006.8.4/bmcewen
|
[494]
|
Dhabhar, F.S. (2019) The Power of Positive Stress—A Complementary Commentary. Stress, 22, 526-529. https://doi.org/10.1080/10253890.2019.1634049
|
[495]
|
Smith, S.M. and Val, W.W. (2006) The Role of Hypothalamic-Pituitary-Adrenal Axis in Neuroendocrine Responses to Stress. Dialogus in Clinical Neuroscience, 8, 383-395. https://doi.org/10.31887/DCNS.2006.8.4/ssmith
|
[496]
|
Klimes-Dougan, B., Chong, L.S., Samikoglu, A., Thai, M., et al. (2020) Transcendental Meditation and Hypothalamic-Pituitary-Adrenalaxis Functioning: A Pilot, Randomizd Controlled Trial with Young Adults. Stress, 23, 105-115. https://doi.org/10.1080/10253890.2019.1656714
|
[497]
|
Yamanaka, Y., Motoshima, H. and Uchida, K. (2019) Hypothalamic-Pituitary-Adrenal Axis Differentially Responses to Morning and Evening Psychological Stress in Healthy Subjects. Neuropsychopharmacology Reports, 39, 41-47. https://doi.org/10.1002/npr2.12042
|
[498]
|
Storm, F.K. (1993) What Happened to Hyperthermia and What Is Its Current Status in Cancer Treatment? Journal of Surgical Oncology, 53, 141-143. https://doi.org/10.1002/jso.2930530302
|
[499]
|
Nielsen, O.S., Horsman, M. and Overgaard, J. (2001) A Future of Hyperthermia in Cancer Treatment? (Editorial Comment). European Journal of Cancer, 37, 1587-1589. https://doi.org/10.1016/S0959-8049(01)00193-9
|
[500]
|
van der Zee, J., Vujaskovic, Z., Kondo, M., et al. (2008) The Kadota Fund International Forum 2004-Clinical Group Consensus. International Journal of Hyperthermia, 24, 111-122. https://doi.org/10.1080/02656730801895058
|
[501]
|
Wust, P. (2019) Physical Rationale about Amplitude Modulated Radiofrequency Hyperthermia. ESHO-2019, Warsaw, 22-24 May 2019.
|
[502]
|
Wust, P. (2019) Advantages of Amplitude Modulation in the Radiofrequency Hyperthermia. IX. DGHT-Kongress, Berlin, 20-21 September 2019.
|