Author(s)

Mamadou Saliou Sow^1*, Karamba Sylla¹, Diao Cissé², Fodé Abass Cissé³, Ibrahima Bah¹, Kadiatou Cissé¹, Kadio Jean Jaques Olivier Kadio²

¹Department of Infectious and Tropical Diseases at Donka National Hospital, Conakry, Guinea.
²Chair of Public Health, Conakry, Guinea.
³Neurology Department of Ignace Deen National Hospital, Conakry, Guinea.

Objectives: To identify predictive factors for poor prognosis during cerebral toxoplasmosis at Donka Hospital. Methods: It was a retrospective study of descriptive and analytic type lasting one year six months (18 months) from January 1^st, 2016 to June 30^th, 2017 which involved patients admitted and hospitalized for cerebral toxoplasmosis in HIV field. Data enter was performed by Epi data 3.1 software and SPSS 21 software for statistical analysis. The threshold of significance was p < 0.05. Results: We observed 87 cases of cerebral toxoplasmosis (CT). The mean age was 38.53 ± 12.16. The clinical signs were mainly infectious syndrome (100%), headache (69.0%), confusion (46.0%) and meningeal syndrome (41.4%). The lethality was 37.9%. Living with a partner (p = 0.007), CD4 at initiation of antiretroviral therapy < 200 cells/mm³ (p = 0.009), and coma (p = 0.02) were the factors associated with death. Conclusion: This study showed that cerebral toxoplasmosis is associated with very high morbidity and mortality in the Infectious Diseases Department of Donka National Hospital. Living in a relationship, CD4 counts at baseline < 200 cells/mm³ and coma were independently associated with death. Special attention to these factors associated with infectious resuscitation and primary prevention in patients with a CD4 T lymphocyte count below 200 cells/mm may improve the prognosis of this pathology.

Cerebral Toxoplasmosis, HIV/AIDS, Donka

Sow, M. , Sylla, K. , Cissé, D. , Cissé, F. , Bah, I. , Cissé, K. and Kadio, K. (2019) Pronostic Factors of Cerebral Toxoplasmosis in Department of Infectious and Tropical Diseases at Donka National Hospital. Advances in Infectious Diseases, 9, 243-251. doi: 10.4236/aid.2019.93018.