Author(s)

Claire Périllaud-Dubois^1,2,3, Elise Bouthry^1,2, François-Charles Javaugue¹, Alexandra Letourneau^2,4, Aurore Bonnin^2,4, Emmanuelle Letamendia^2,5, Christelle Vauloup-Fellous^1,2,6*

¹AP-HP, WHO Rubella National Reference Laboratory, Department of Virology, Paul-Brousse Hospital, Villejuif, France.
²Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Paris, France.
³IAME, INSERM UMR1137, University Paris Diderot, Paris, France.
⁴AP-HP, Service de Gynécologie-Obstétrique, Antoine Béclère Hospital, Clamart, France.
⁵AP-HP, Service de Néonatologie, Antoine Béclère Hospital, Clamart, France.
⁶INSERM U1193, University Paris Sud, Villejuif, France.

Background: Co-infections may represent substantial diagnostic and treatment challenges. Aim: To the better of our knowledge, we describe the first case in the literature of congenital Cytomegalovirus (CMV) infection following maternal CMV non primary infection contemporary to varicella during pregnancy. Case Presentation: A pregnant woman had a varicella during her pregnancy. Congenital CMV infection was fortuitously discovered in the neonate owing to a universal CMV screening. Retrospective analysis of maternal serums during pregnancy showed CMV reactivation. We aim to highlight that CMV reactivation could be due to varicella and discuss if it could facilitate the transplacental transmission of CMV. Conclusion: This case report emphasizes neonatal CMV screening, and warns against dual maternal infection especially because this may be at particular risk of transmission to the fetus.

cCMV, VZV, Intercurrent Infection, Asymptomatic Congenital CMV Infection

Périllaud-Dubois, C. , Bouthry, E. , Javaugue, F. , Letourneau, A. , Bonnin, A. , Letamendia, E. and Vauloup-Fellous, C. (2019) Congenital Cytomegalovirus Infection and Maternal Varicella during Pregnancy. Is There a Coincidence? A Case Report. Open Journal of Obstetrics and Gynecology, 9, 1221-1225. doi: 10.4236/ojog.2019.99119.