Ecological security is an overall reflection of the ecological integrity and health level of natural semi-natural ecosystems. The study obtained quantitative results of ecological land-use variety by using spatial transfer matrix, based on status maps of Anqing City in 2005 and 2017. We combined the superposition analysis of ecological sensitivity with ecological disturbance evaluation to judge the strategic nodes and corridors of core protection type, including maintenance promotion type and potential supplementary type in the study area. In addition, we introduced the model of minimum cumulative resistance to construct the ecological security pattern, superimposing with the results of ecological land use. According to the trend of change over the past decade, the study has the great significance to the ecological security pattern so that we can effectively guide to take management strategy for security landscape.