The study explored the relationship between physical security and survival of small and medium scale enterprises (SMEs) in Southeast, Nigeria. The objectives of the study are to determine the nature of relationships that exist between fire outbreak and entrepreneurial vision, burglary attacks and delivery-time of products by SMEs in Southeast, Nigeria. Correlation survey research design was employed in the study. Pearson product moment correlation coefficient was used to test the formulated hypotheses at 5% (percent) level of significance. Findings revealed that there were negative significant relationships that exist between fire outbreaks and entrepreneurial visions of SMEs’ owners, burglary attacks and delivery-time of products to customers by SMEs in the region. In addition, the constructs were significant at 0.05 level (2-tailed). It is recommended that owners of businesses should ensure commitment to fire safety by putting necessary resources for fire control (suppression agents and personnel training) and procedures (compliance with fire disaster preparedness bylaws). Further, business owners need to provide multiple layers of security (defense in depth) around business areas. We therefore advocate that for business continuity in the region, rapid response to fire outbreaks, burglary attacks and comprehensive preventive strategies are vital.