DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level - Journal of Biophysical Chemistry

JBPC > Vol.9 No.3, August 2018

DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level ()

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DOI: 10.4236/jbpc.2018.93003 1,149 Downloads 2,044 Views

Author(s)

Henk M. Buck

Affiliation(s)

Kasteel Twikkelerf 94, Tilburg, The Netherlands.

ABSTRACT

The new epigenetic elements 5-hydroxymethyl-dC, 5-formyl-dC, and 5-car- boxy-dC may be considered as intermediates of an active demethylation process. A comprehensive mechanistic model is given for the C-C bond cleavage focused on the chemistry within the DNA duplex structure. In addition we register spin-off chemistry of this process in evaluating new duplex systems closely related to natural DNA and RNA concerning their hydrogen-bond symmetrization. A model is composed for a base-specific inhibition of G and C on the DNA and RNA level. C-G combinations are of general importance in controlling the dynamics of gene expression. In some way the suggested model systems are related to antisense oligonucleotides (ASOs).

KEYWORDS

Active Demethylation, DNA Catalysis, Symmetry Elements, (Anti)Parallel Modified DNA and RNA, Inhibition of Genetic Information

Share and Cite:

Buck, H. (2018) DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level. Journal of Biophysical Chemistry, 9, 23-40. doi: 10.4236/jbpc.2018.93003.

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