In recent years, sarcopenia began to receive attention. Not only the elderly, hyperthyroidism patients also suffer from sarcopenia. The purpose of this study is to explore the relevant factors for sarcopenia in hyperthyroidism patients. [Methods]: Dual energy X-ray was used to detect the muscle mass in 101 hyperthyroidism patients (23 males and 78 females, mean age 45.77 ± 15.02 years), and calculate SMI. Pearson correlation analysis was performed to examine the relationship between SMI and Age, BMI, Fat amount, Grip, SBP, DBP, FT3, FT4, TSH, Ca, P, TC, TG, LDL-C, HDL-C, FPG, LA, IL-6, TNF-a respectively. Spearman correlation analysis was performed to examine the relationship between gender respectively. The influencing factors of relative SMI status were selected by stepwise regression analysis. [Results]: Based on Pearson and Spearman analysis, Gender (r = ﹣0.567, p < 0.001), BMI (r = 0.245, p = 0.014), grip (r = 0.670, p < 0.001), TC (r = 0.221, p = 0.026), lactic acid (r = ﹣0.196, p= 0.050) is significantly correlated with sarcopenia in hyperthyroidism patients. Stepwise regression analysis showed that there existed the close correlations between gender, BMI, grip and SMI, Y = 4.805 ﹣ 0.985 gender 0.044 BMI 0.045 grip. [Conclusion]: As a risk of sarcopenia in hyperthyroidism patients, there was a correlation with gender, grip strength and BMI. Not only the elderly, young patients with hyperthyroidism should also pay attention to sarcopenia.