Author(s)

Susanne Finger¹, Michael Zieger¹, Cornelia Wiegand¹, Tim Liebert², Thomas Heinze², Peter Elsner¹, Uta-Christina Hipler¹

¹Department of Dermatology, University Medical Center, Jena, Germany.
²Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University, Jena, Germany.

Recently, there is a need of alternatives to antibiotics due to increasing antibiotic-resistant microorganism. Promising classes of bioactive polymers are 6-deoxy-6-amino cellulose derivatives. The purpose of the study was the assessment of the biocompatibility of 6-deoxy-6-aminoethyleneamino cellulose (AEAC) with different degree of substitution (DS). HaCaT keratinocyte cell viability was analyzed by measuring the cellular ATP content. The antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae was examined by microplate laser nephelometry. Thus, the ratio of half-maximal lethal concentration (LC₅₀) and half-maximal inhibitory concentration (IC₅₀) was calculated and described as biocompatibility index. The study revealed that biocompatibility of AEAC depends on the DS. AEAC of low DS (0.3) showed the best biocompatibility.

6-Deoxy-6-Aminoethyleneamino Celluloses, Antibacterial, Bacteria, Biocompatibility, Biomacromolecule, Keratinocyte

Finger, S. , Zieger, M. , Wiegand, C. , Liebert, T. , Heinze, T. , Elsner, P. and Hipler, U. (2018) Biocompatibility and Antibacterial Effects of 6-Deoxy-6-Aminoethyleneamino Cellulose. Journal of Biosciences and Medicines, 6, 51-62. doi: 10.4236/jbm.2018.61006.