Author(s)

Md Kamrul Hasan

Moores Cancer Center, University of California San Diego, Health Sciences Dr, La Jolla, CA, USA.

Neuroblastoma (NBL) is one of the most common solid tumors and around 15% of cancer mortality in children. Amplification of the N-Myc proto-oncogene is strongly correlated with advanced disease and poor clinical outcome in NBL. Recent studies described that ubiquitin-specific protease 7 (USP7; also known as HAUSP) interacts with N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that in-turn potentiates N-Myc function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.

Neuroblastoma, N-Myc, PI3K/mTOR, PARP1, PD-L1, HAUSP

Hasan, M. (2017) N-Myc Inhibition: Advances in Neuroblastoma Treatment. CellBio, 6, 27-34. doi: 10.4236/cellbio.2017.63003.