Author(s)

Ramakrishna Vellalacheruvu^*, Ramayanam Sai Leela, L. K. Ravindranath

Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India.

The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.

Imidazole Analogues, Thiozolidine-2, 4-Dione Nucleus, Toluenesulfonylmethyl Isocyanide, Combi-Flash Column Chromatography

Vellalacheruvu, R. , Leela, R. and Ravindranath, L. (2017) Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base. International Journal of Organic Chemistry, 7, 269-283. doi: 10.4236/ijoc.2017.73021.