Author(s)

Nankang G. Lepzem¹, Rachel Adetoro Togun²

¹Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Jos, Nigeria.
²Depatment of Haematology and Immunology, Obafemi Awolowo University, Ile-Ife, Nigeria.

Methanolic extracts of Tetracarpidium conophorum (TCME) leaf, seed or leaf + seed extract demonstrated high capacity for reversing hyperglycemia and oxidative stress comparable with the standard anti-diabetic drug, metformin, in alloxan-induced diabetic rats. The leaf + seed extracts showed the best activity among the extracts and also ameliorated oxidative stress-induced damage of pancreas and liver tissue to normal state.

Antidiabetic, Glucose, MDA, GSH, Lipids, T. conophorum

Lepzem, N. and Togun, R. (2017) Antidiabetic and Antioxidant Effects of Methanolic Extracts of Leaf and Seed of Tetracarpidium conophorum on Alloxan-Induced Diabetic Wistar Rats. Journal of Biomedical Science and Engineering, 10, 402-420. doi: 10.4236/jbise.2017.108031.