Author(s)

Kanae Niimi^1*, Michiko Yoshizawa^1,2, Takahiro Koyama³, Akinori Funayama¹, Toshihiko Mikami¹, Tadaharu Kobayashi¹

¹Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
²Department of Oral and Maxillofacial Surgery, School of Dentistry, Matsumoto Dental University, Shiojiri, Japan.
³Division of Oral and Maxillofacial Surgery, Department of Oral Health, Course of Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Platelet-rich plasma (PRP) has been used as a therapeutic tool to promote wound healing, in orthopedics, dermatology, oral surgery, etc. However, the mechanisms underlying the wound healing effects of PRP remain unclear. The purpose of this study was to evaluate the effectiveness of applying PRP, particularly in the management of tooth extraction sockets. Three upper molars of Fischer rats were extracted, and blood was drawn from the hearts of other rats to prepare PRP. The PRP was activated and applied to the bone defects of the experimental group, and nothing was applied to the bone defects of the control group. On day 3, fibrin network and granulation tissue, which are abundant in blood capillaries, were seen under the PRP layer in the experimental group. On the other hand, only inflammatory cells and a fibrin network were observed in the bone defects of the control group. On day 7, granulation tissue was seen in the bone defects in both the control group and experimental group, although excavation of granulation tissue was noted in the control group. The results demonstrated the presence of a rich fibrin network and early inflammatory reactions in the experimental group, which may lead to rise of thick, vessel-rich granulation tissue. The application of PRP may stimulate wound healing in tooth extraction bone defects, and PRP may confer some beneficial effects on the outcomes.

Platelet Rich Plasma, Wound Healing, Bone Defect

Niimi, K. , Yoshizawa, M. , Koyama, T. , Funayama, A. , Mikami, T. and Kobayashi, T. (2017) An Experimental Study on the Effects of Platelet Rich Plasma on the Wound Healing of Tooth Extraction-Related Bone Defects. Open Journal of Stomatology, 7, 327-335. doi: 10.4236/ojst.2017.78027.