Author(s)

Lucilene Fernandes Silva¹, Maria das Graças Cardoso^1*, Paulo Sérgio Castilho Preté¹, Maria Luisa Teixeira¹, David Lee Nelson², Maísa Lamounier Magalhães³, Vanuzia Rodrigues Fernandes Ferreira¹, Rafaela Vieira Souza¹, Luana Isac Soares¹, Silvana Marcussi¹

¹Departamento de Química, Universidade Federal de Lavras, Campus Universitário, Lavras, Minas Gerais, Brasil.
²Departamento de Química, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Campus Universitário, Diamantina, Minas Gerais, Brasil.
³Departamento de Ciência dos Alimentos, Universidade Federal de Lavras, Campus Universitário, Lavras, Minas Gerais, Brasil.

The essential oils from Mentha viridis (L). L. and Mentha pulegium L. were studied to assess their inhibitory potential on phospholipase from snake venoms and to determine their cytogenotoxic action on human cells. These essential oils were able to inhibit the breakdown of phospholipids induced by venoms of snakes of the Bothrops genus. Both oils presented hemolytic activity, although the Mentha viridis (L). L. oil induced hemolysis only at the highest concentrations (14.6 and 29 μL·mL^-1). The essential oil from M. viridis induced 3.9; 8.6 and 16.2 times greater damage to human leukocyte DNA than that observed with the positive control (100 μg·μL^-1 doxorubicin) at concentrations of 0.25; 0.5 and 1.0 μL·mL^-1, respectively. A similar effect was observed for the oil from M. pulegium (2.1, 2.5 and 15.8 times greater damage). The results extend the characterization of these essential oils and demonstrate their potential use in industries.

Essential Oils, Mentha viridis (L). L., Mentha pulegium L., Hemolysis, Comet Assay

Silva, L. , Cardoso, M. , Preté, P. , Teixeira, M. , Nelson, D. , Magalhães, M. , Ferreira, V. , Souza, R. , Soares, L. and Marcussi, S. (2017) Essential Oils from Mentha viridis (L). L. and Mentha pulegium L.: Cytogenotoxic Effects on Human Cells. American Journal of Plant Sciences, 8, 1423-1437. doi: 10.4236/ajps.2017.86097.