Author(s)

Tabinda Sattar, Muhammad Athar

Instituite of chemical sciences, B.Z.U Multan, Pakistan.

A new porous compound, Copper glycinate (Bio-MOF-29), [Cu(C₂H₄NO₂)₂ (H₂O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P2₁2₁2₁ space group. In vitro adsorption studies of four different drugs, terazosine hydrochloride, telmisartan, glimpiride and rosuvastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfuly adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.

Bio-Metal Organic Framework, Glycine, Single Crystal XRD Analysis, High Performance Liquid Chromatography, Terazosine HCl, Telmisartan, Glimpiride, Rosuvastatin, Bio-MOF-29

Sattar, T. and Athar, M. (2017) Hydrothermal Synthesis and Characterization of Copper Glycinate (Bio-MOF-29) and Its in Vitro Drugs Adsorption Studies. Open Journal of Inorganic Chemistry, 7, 17-27. doi: 10.4236/ojic.2017.72002.