Author(s)

Mukta Sachdev^1,2, Anoop Chullikana³, Raviraja N. Seetharam³, Rachana Shilpakar², R. Sapna², Keerthi Velugotla², Ritambhara  ², Anish S. Majumdar³, Pawan Kumar Gupta^3*

¹Manipal Hospital, Bangalore, India.
²MS Skin Centre, Bangalore, India.
³Stempeutics Research Pvt. Ltd., Bangalore, India.

Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bone-marrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV - VI of Norwood Scale for a duration of 90 days. Parameters—fine lines, wrinkles, crow’s feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 - 30 days. Product was safe and well tolerated as per the dermatologist and subjects’ self-assessment.

Cytokines, Conditioned Media, Crow’s Feet, Anti-Ageing

Sachdev, M. , Chullikana, A. , Seetharam, R. , Shilpakar, R. , Sapna, R. , Velugotla, K. ,  , R. , Majumdar, A. and Gupta, P. (2017) A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population. Journal of Cosmetics, Dermatological Sciences and Applications, 7, 118-132. doi: 10.4236/jcdsa.2017.71011.