Author(s)

Ju-Hua Hou¹, Zheng-Bing He², Xiao-Ju Hou³, Yuan-Yue Liu^1*, Wen-Jiang Zhang¹, Juan Duan¹

¹Department of Pathology, Yiyang Medical University, Yiyang, China.
²Respiratory Medicine of Yiyang Central Hospital, Yiyang, China.
³School of Foreign Languages, Henan University of Technology, Zhengzhou, China.

Objective: To detect the expression and pathological significances of Interleukin-6 (IL-6) and basic fibroblast growth factor (bFGF) in tongue squamous cell carcinoma (TSCC). Methods: A tissue array was analyzed immunohistochemically. The expression levels of IL-6 and bFGF in tissues were recorded semi-quantitatively. Results: The positive expression of IL-6 in normal, benign tumor, and carcinoma groups was 12.50% ± 5.575%, 39.00% ± 1.41%, 77.26% ± 17.07% respectively, and the expression among the three groups showed significant differences (P < 0.05). The expression of bFGF in benign tumor was lower than that in normal groups and squamous cell carcinoma. The positive expression was 6.50% ± 2.12%, 23.75% ± 4.79%, 42.33% ± 29.89% respectively, and the expression among the three groups showed significant differences (P < 0.05). Furthermore, there were positive correlations between IL-6 and bFGF (P < 0.05). Conclusion: It indicates that combining immunohistochemical examination of IL-6 and bFGF has an important reference value on the pathological diagnosis of tongue squamous cell carcinoma.

Tongue Squamous Cell Carcinoma, Il-6, bFGF, Tissue Array

Hou, J. , He, Z. , Hou, X. , Liu, Y. , Zhang, W. and Duan, J. (2017) Expression and Significance of IL-6 and bFGF in Human Tongue Squamous Cell Carcinoma. Journal of Cancer Therapy, 8, 210-215. doi: 10.4236/jct.2017.82017.